Depletion of T-tubules and specific subcellular changes in sarcolemmal proteins in tachycardia-induced heart failure

The T-tubule membrane network is integrally involved in excitation-contraction coupling in ventricular myocytes. Ventricular myocytes from canine hearts with tachycardia-induced dilated cardiomyopathy exhibit a decrease in accessible T-tubules to the membrane-impermeant dye, di8-ANNEPs. The present...

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Veröffentlicht in:	Cardiovascular research 2003-07, Vol.59 (1), p.67-77
Hauptverfasser:	BALIJEPALLI, Ravi C, LOKUTA, Andrew J, MAERTZ, Nathan A, BUCK, Jennifer M, HAWORTH, Robert A, VALDIVIA, Hector H, KAMP, Timothy J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Calcium Channels, L-Type - analysis Calcium-Transporting ATPases - analysis Calsequestrin - analysis Cardiac Pacing, Artificial Cardiology. Vascular system Cell Fractionation Cells, Cultured Dogs Electrophysiology Heart Heart Failure - metabolism Heart failure, cardiogenic pulmonary edema, cardiac enlargement Homeodomain Proteins - analysis Isradipine - metabolism Medical sciences Microscopy, Confocal Microscopy, Fluorescence Muscle Proteins - metabolism Myocytes, Cardiac - metabolism Myocytes, Cardiac - ultrastructure Protein Binding Receptors, Adrenergic, beta - analysis Ryanodine - metabolism Sarcolemma - metabolism Sarcolemma - ultrastructure Sarcoplasmic Reticulum - metabolism Sarcoplasmic Reticulum - ultrastructure Sarcoplasmic Reticulum Calcium-Transporting ATPases Sodium-Calcium Exchanger - analysis Sodium-Potassium-Exchanging ATPase - analysis
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