Inhibition of oxygen radical formation by methylene blue, aspirin, or alpha-lipoic acid, prevents bacterial-lipopolysaccharide-induced fever

Phagocytic cells contain NADPH oxidase that they use for host defense by catalyzing the production of superoxide. Bacterial lipopolysaccharide (LPS) has been found to stimulate NADPH oxidase in mobile and sessile macrophages and microglia. It also evokes fever in homeothermic animals and men, a reac...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Molecular and cellular biochemistry 2003-05, Vol.247 (1-2), p.83-94
Hauptverfasser:	Riedel, Walter, Lang, Uwe, Oetjen, Ulrich, Schlapp, Ulrike, Shibata, Masaaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antioxidants - metabolism Aspirin - pharmacology Bacterial Infections - complications Bacterial Infections - etiology Brain - drug effects Brain - metabolism Catalase - blood Catalase - cerebrospinal fluid Endotoxins - blood Endotoxins - cerebrospinal fluid Female Fever - etiology Fever - metabolism Fever - prevention & control Formazans - analysis Formazans - metabolism Hydrogen Peroxide - blood Hydrogen Peroxide - cerebrospinal fluid Injections, Intravenous Lipopolysaccharides - administration & dosage Lipopolysaccharides - blood Lipopolysaccharides - cerebrospinal fluid Methylene Blue - pharmacology Perfusion Rabbits Reactive Oxygen Species - metabolism Subarachnoid Space - drug effects Subarachnoid Space - metabolism Thioctic Acid - analogs & derivatives Thioctic Acid - metabolism Thioctic Acid - pharmacokinetics Thioctic Acid - pharmacology Tumor Necrosis Factor-alpha - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!