Cerebral blood flow and anxiety in older men: An analysis of resting anterior asymmetry and prefrontal regions
Asymmetric resting blood flow in prefrontal and hemispheric regions, assessed by single photon emission computed tomography (SPECT), was examined as a potential biological marker for enhanced trait and state anxiety in 30 older men (ages 55–81). Average and asymmetric perfusion in dorsolateral, medi...
Gespeichert in:
| Veröffentlicht in: | Brain and cognition 2003-06, Vol.52 (1), p.70-78 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 78 |
|---|---|
| container_issue | 1 |
| container_start_page | 70 |
| container_title | Brain and cognition |
| container_volume | 52 |
| creator | Tankard, Carol F. Waldstein, Shari R. Siegel, Eliot L. Holder, Lawrence E. Lefkowitz, David Anstett, Frank Katzel, Leslie I. |
| description | Asymmetric resting blood flow in prefrontal and hemispheric regions, assessed by single photon emission computed tomography (SPECT), was examined as a potential biological marker for enhanced trait and state anxiety in 30 older men (ages 55–81). Average and asymmetric perfusion in dorsolateral, medial, and orbital regions of the prefrontal lobes was also assessed. Results indicated a significant association between lower levels of resting dorsolateral blood flow and greater state anxiety responses to a series of stressful provocations (measured on a separate occasion). A significant curvilinear (U-shaped) relation between asymmetric dorsolateral perfusion and state anxiety was also identified; increased asymmetric blood flow favoring either the right or the left dorsolateral region related to higher levels of state anxiety. However, this association was attenuated by age and systolic blood pressure. Resting perfusion in the dorsolateral region may represent a more reliable biological marker for state anxiety than trait anxiety in older men. |
| doi_str_mv | 10.1016/S0278-2626(03)00010-1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_73437666</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0278262603000101</els_id><sourcerecordid>20569419</sourcerecordid><originalsourceid>FETCH-LOGICAL-c392t-d2128499b55fce6fb22c2ce914dab87f62a86af3832d690743fe6eb23d30cfac3</originalsourceid><addsrcrecordid>eNqFkU1LJDEQhoO46PjxE5ScRA-9m4-edMeLyLDqgrCH1XNIJxWJdCdj0qP2v984M-hRSBFIPfVWpV6ETij5SQkVv_4R1rQVE0ycE35BCKGkojtoRokkFaN1s4tmn8g-Osj5uUCyZmwP7VPWlkPEDIUFJOiS7nHXx2ix6-Mb1sGWePcwTtgHHHsLCQ8QLvF1KAndT9lnHB1OkEcfnsrbCMnHhHWehgHGNK01lglcimEs6gmefAz5CP1wus9wvL0P0ePN74fFXXX_9_bP4vq-MlyysbKsjFdL2c3nzoBwHWOGGZC0trprGyeYboV2vOXMCkmamjsQ0DFuOTFOG36Izja6yxRfVmVKNfhsoO91gLjKquE1b4QQ34KMzIWsqSzgfAOaFHMuH1PL5AedJkWJ-nBErR1RH-tWhKu1I4qWutNtg1U3gP2q2lpQgKsNAGUfrx6SysZDMGB9AjMqG_03Lf4DdJqcRQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>20569419</pqid></control><display><type>article</type><title>Cerebral blood flow and anxiety in older men: An analysis of resting anterior asymmetry and prefrontal regions</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Tankard, Carol F. ; Waldstein, Shari R. ; Siegel, Eliot L. ; Holder, Lawrence E. ; Lefkowitz, David ; Anstett, Frank ; Katzel, Leslie I.</creator><creatorcontrib>Tankard, Carol F. ; Waldstein, Shari R. ; Siegel, Eliot L. ; Holder, Lawrence E. ; Lefkowitz, David ; Anstett, Frank ; Katzel, Leslie I.</creatorcontrib><description>Asymmetric resting blood flow in prefrontal and hemispheric regions, assessed by single photon emission computed tomography (SPECT), was examined as a potential biological marker for enhanced trait and state anxiety in 30 older men (ages 55–81). Average and asymmetric perfusion in dorsolateral, medial, and orbital regions of the prefrontal lobes was also assessed. Results indicated a significant association between lower levels of resting dorsolateral blood flow and greater state anxiety responses to a series of stressful provocations (measured on a separate occasion). A significant curvilinear (U-shaped) relation between asymmetric dorsolateral perfusion and state anxiety was also identified; increased asymmetric blood flow favoring either the right or the left dorsolateral region related to higher levels of state anxiety. However, this association was attenuated by age and systolic blood pressure. Resting perfusion in the dorsolateral region may represent a more reliable biological marker for state anxiety than trait anxiety in older men.</description><identifier>ISSN: 0278-2626</identifier><identifier>EISSN: 1090-2147</identifier><identifier>DOI: 10.1016/S0278-2626(03)00010-1</identifier><identifier>PMID: 12812806</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aged ; Aged, 80 and over ; Anxiety Disorders - diagnosis ; Anxiety Disorders - physiopathology ; Functional Laterality - physiology ; Hemodynamics - physiology ; Humans ; Magnetic Resonance Angiography ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Prefrontal Cortex - blood supply ; Prefrontal Cortex - pathology ; Prefrontal Cortex - physiopathology ; Severity of Illness Index ; Surveys and Questionnaires ; Tomography, Emission-Computed, Single-Photon</subject><ispartof>Brain and cognition, 2003-06, Vol.52 (1), p.70-78</ispartof><rights>2003 Elsevier Science (USA)</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c392t-d2128499b55fce6fb22c2ce914dab87f62a86af3832d690743fe6eb23d30cfac3</citedby><cites>FETCH-LOGICAL-c392t-d2128499b55fce6fb22c2ce914dab87f62a86af3832d690743fe6eb23d30cfac3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0278-2626(03)00010-1$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12812806$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tankard, Carol F.</creatorcontrib><creatorcontrib>Waldstein, Shari R.</creatorcontrib><creatorcontrib>Siegel, Eliot L.</creatorcontrib><creatorcontrib>Holder, Lawrence E.</creatorcontrib><creatorcontrib>Lefkowitz, David</creatorcontrib><creatorcontrib>Anstett, Frank</creatorcontrib><creatorcontrib>Katzel, Leslie I.</creatorcontrib><title>Cerebral blood flow and anxiety in older men: An analysis of resting anterior asymmetry and prefrontal regions</title><title>Brain and cognition</title><addtitle>Brain Cogn</addtitle><description>Asymmetric resting blood flow in prefrontal and hemispheric regions, assessed by single photon emission computed tomography (SPECT), was examined as a potential biological marker for enhanced trait and state anxiety in 30 older men (ages 55–81). Average and asymmetric perfusion in dorsolateral, medial, and orbital regions of the prefrontal lobes was also assessed. Results indicated a significant association between lower levels of resting dorsolateral blood flow and greater state anxiety responses to a series of stressful provocations (measured on a separate occasion). A significant curvilinear (U-shaped) relation between asymmetric dorsolateral perfusion and state anxiety was also identified; increased asymmetric blood flow favoring either the right or the left dorsolateral region related to higher levels of state anxiety. However, this association was attenuated by age and systolic blood pressure. Resting perfusion in the dorsolateral region may represent a more reliable biological marker for state anxiety than trait anxiety in older men.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anxiety Disorders - diagnosis</subject><subject>Anxiety Disorders - physiopathology</subject><subject>Functional Laterality - physiology</subject><subject>Hemodynamics - physiology</subject><subject>Humans</subject><subject>Magnetic Resonance Angiography</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Prefrontal Cortex - blood supply</subject><subject>Prefrontal Cortex - pathology</subject><subject>Prefrontal Cortex - physiopathology</subject><subject>Severity of Illness Index</subject><subject>Surveys and Questionnaires</subject><subject>Tomography, Emission-Computed, Single-Photon</subject><issn>0278-2626</issn><issn>1090-2147</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1LJDEQhoO46PjxE5ScRA-9m4-edMeLyLDqgrCH1XNIJxWJdCdj0qP2v984M-hRSBFIPfVWpV6ETij5SQkVv_4R1rQVE0ycE35BCKGkojtoRokkFaN1s4tmn8g-Osj5uUCyZmwP7VPWlkPEDIUFJOiS7nHXx2ix6-Mb1sGWePcwTtgHHHsLCQ8QLvF1KAndT9lnHB1OkEcfnsrbCMnHhHWehgHGNK01lglcimEs6gmefAz5CP1wus9wvL0P0ePN74fFXXX_9_bP4vq-MlyysbKsjFdL2c3nzoBwHWOGGZC0trprGyeYboV2vOXMCkmamjsQ0DFuOTFOG36Izja6yxRfVmVKNfhsoO91gLjKquE1b4QQ34KMzIWsqSzgfAOaFHMuH1PL5AedJkWJ-nBErR1RH-tWhKu1I4qWutNtg1U3gP2q2lpQgKsNAGUfrx6SysZDMGB9AjMqG_03Lf4DdJqcRQ</recordid><startdate>20030601</startdate><enddate>20030601</enddate><creator>Tankard, Carol F.</creator><creator>Waldstein, Shari R.</creator><creator>Siegel, Eliot L.</creator><creator>Holder, Lawrence E.</creator><creator>Lefkowitz, David</creator><creator>Anstett, Frank</creator><creator>Katzel, Leslie I.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope><scope>8BM</scope></search><sort><creationdate>20030601</creationdate><title>Cerebral blood flow and anxiety in older men: An analysis of resting anterior asymmetry and prefrontal regions</title><author>Tankard, Carol F. ; Waldstein, Shari R. ; Siegel, Eliot L. ; Holder, Lawrence E. ; Lefkowitz, David ; Anstett, Frank ; Katzel, Leslie I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c392t-d2128499b55fce6fb22c2ce914dab87f62a86af3832d690743fe6eb23d30cfac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anxiety Disorders - diagnosis</topic><topic>Anxiety Disorders - physiopathology</topic><topic>Functional Laterality - physiology</topic><topic>Hemodynamics - physiology</topic><topic>Humans</topic><topic>Magnetic Resonance Angiography</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Prefrontal Cortex - blood supply</topic><topic>Prefrontal Cortex - pathology</topic><topic>Prefrontal Cortex - physiopathology</topic><topic>Severity of Illness Index</topic><topic>Surveys and Questionnaires</topic><topic>Tomography, Emission-Computed, Single-Photon</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tankard, Carol F.</creatorcontrib><creatorcontrib>Waldstein, Shari R.</creatorcontrib><creatorcontrib>Siegel, Eliot L.</creatorcontrib><creatorcontrib>Holder, Lawrence E.</creatorcontrib><creatorcontrib>Lefkowitz, David</creatorcontrib><creatorcontrib>Anstett, Frank</creatorcontrib><creatorcontrib>Katzel, Leslie I.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><collection>ComDisDome</collection><jtitle>Brain and cognition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tankard, Carol F.</au><au>Waldstein, Shari R.</au><au>Siegel, Eliot L.</au><au>Holder, Lawrence E.</au><au>Lefkowitz, David</au><au>Anstett, Frank</au><au>Katzel, Leslie I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cerebral blood flow and anxiety in older men: An analysis of resting anterior asymmetry and prefrontal regions</atitle><jtitle>Brain and cognition</jtitle><addtitle>Brain Cogn</addtitle><date>2003-06-01</date><risdate>2003</risdate><volume>52</volume><issue>1</issue><spage>70</spage><epage>78</epage><pages>70-78</pages><issn>0278-2626</issn><eissn>1090-2147</eissn><abstract>Asymmetric resting blood flow in prefrontal and hemispheric regions, assessed by single photon emission computed tomography (SPECT), was examined as a potential biological marker for enhanced trait and state anxiety in 30 older men (ages 55–81). Average and asymmetric perfusion in dorsolateral, medial, and orbital regions of the prefrontal lobes was also assessed. Results indicated a significant association between lower levels of resting dorsolateral blood flow and greater state anxiety responses to a series of stressful provocations (measured on a separate occasion). A significant curvilinear (U-shaped) relation between asymmetric dorsolateral perfusion and state anxiety was also identified; increased asymmetric blood flow favoring either the right or the left dorsolateral region related to higher levels of state anxiety. However, this association was attenuated by age and systolic blood pressure. Resting perfusion in the dorsolateral region may represent a more reliable biological marker for state anxiety than trait anxiety in older men.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>12812806</pmid><doi>10.1016/S0278-2626(03)00010-1</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0278-2626 |
| ispartof | Brain and cognition, 2003-06, Vol.52 (1), p.70-78 |
| issn | 0278-2626 1090-2147 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_73437666 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Aged Aged, 80 and over Anxiety Disorders - diagnosis Anxiety Disorders - physiopathology Functional Laterality - physiology Hemodynamics - physiology Humans Magnetic Resonance Angiography Magnetic Resonance Imaging Male Middle Aged Prefrontal Cortex - blood supply Prefrontal Cortex - pathology Prefrontal Cortex - physiopathology Severity of Illness Index Surveys and Questionnaires Tomography, Emission-Computed, Single-Photon |
| title | Cerebral blood flow and anxiety in older men: An analysis of resting anterior asymmetry and prefrontal regions |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T23%3A49%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cerebral%20blood%20flow%20and%20anxiety%20in%20older%20men:%20An%20analysis%20of%20resting%20anterior%20asymmetry%20and%20prefrontal%20regions&rft.jtitle=Brain%20and%20cognition&rft.au=Tankard,%20Carol%20F.&rft.date=2003-06-01&rft.volume=52&rft.issue=1&rft.spage=70&rft.epage=78&rft.pages=70-78&rft.issn=0278-2626&rft.eissn=1090-2147&rft_id=info:doi/10.1016/S0278-2626(03)00010-1&rft_dat=%3Cproquest_cross%3E20569419%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=20569419&rft_id=info:pmid/12812806&rft_els_id=S0278262603000101&rfr_iscdi=true |