Resistance training with vascular occlusion: Metabolic adaptations in human muscle
Two recent studies have reported increases in strength and whole muscle cross-sectional area after low-intensity resistance training (LIT) with vascular occlusion (OCC) that are greater than LIT alone (e.g., 22, 25). The OCC stress might be expected to induce metabolic alterations that are consisten...
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| Veröffentlicht in: | Medicine and science in sports and exercise 2003-07, Vol.35 (7), p.1203-1208 |
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| creator | BURGOMASTER, Kirsten A MOORE, Dan R SCHOFIELD, Lee M PHILLIPS, Stuart M SALE, Digby G GIBALA, Martin J |
| description | Two recent studies have reported increases in strength and whole muscle cross-sectional area after low-intensity resistance training (LIT) with vascular occlusion (OCC) that are greater than LIT alone (e.g., 22, 25). The OCC stress might be expected to induce metabolic alterations that are consistent with compromised oxygen delivery rather than an increase in strength per se, but this has not been studied.
We examined the effect of LIT and LIT+OCC on resting metabolites in m. biceps brachii and elbow flexor strength.
Eight men (19.5 +/- 0.4 yr) performed 8 wk of LIT at approximately 50% of one-repetition maximum (2 sessions per week; 3-6 sets, 8-10 repetitions, final set to failure); one arm trained with OCC and the other without (CON). :Biopsies obtained before and 72 h after the final training bout revealed that resting [glycogen] was higher (P |
| doi_str_mv | 10.1249/01.MSS.0000074458.71025.71 |
| format | Article |
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We examined the effect of LIT and LIT+OCC on resting metabolites in m. biceps brachii and elbow flexor strength.
Eight men (19.5 +/- 0.4 yr) performed 8 wk of LIT at approximately 50% of one-repetition maximum (2 sessions per week; 3-6 sets, 8-10 repetitions, final set to failure); one arm trained with OCC and the other without (CON). :Biopsies obtained before and 72 h after the final training bout revealed that resting [glycogen] was higher (P <or= 0.05) in both arms after LIT (CON: 452 +/- 20 vs 325 +/- 28, OCC: 501 +/- 12 vs 332 +/- 28 mmol.kg-1 dry weight) and the increase was larger in the OCC arm (P <or= 0.05). Resting [ATP] was lower (P <or= 0.05) after LIT in both arms (CON: 20.5 +/- 0.5 vs 22.8 +/- 0.7, OCC: 18.2 +/- 0.6 vs 23.1 +/- 0.5 mmol.kg-1 dry weight), and the decrease was larger in the OCC arm (P <or= 0.05). Maximal isotonic and isokinetic elbow flexor strength increased (P <or= 0.05) after training to a similar extent in both arms.
We conclude that [glycogen] was increased and [ATP] was decreased in resting human muscle, 72 h after an 8-wk LIT protocol. OCC potentiated the metabolic changes, perhaps by inducing an ischemic stimulus that enhanced muscle glucose transport and adenine nucleotide catabolism after LIT, but did not augment the increases in strength.</description><identifier>ISSN: 0195-9131</identifier><identifier>EISSN: 1530-0315</identifier><identifier>DOI: 10.1249/01.MSS.0000074458.71025.71</identifier><identifier>PMID: 12840643</identifier><identifier>CODEN: MSPEDA</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Adaptation, Physiological ; Adenosine Triphosphate - metabolism ; Adolescent ; Adult ; Arm - blood supply ; Arm - physiology ; Biological and medical sciences ; Blood and lymphatic vessels ; Cardiology. Vascular system ; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous ; Exercise - physiology ; Glucose - metabolism ; Humans ; Ischemia ; Male ; Medical sciences ; Muscle Fatigue ; Muscle, Skeletal - blood supply ; Muscle, Skeletal - physiology ; Regional Blood Flow ; Space life sciences ; Weight Lifting</subject><ispartof>Medicine and science in sports and exercise, 2003-07, Vol.35 (7), p.1203-1208</ispartof><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c485t-6080169e64b7157f28e270d56607953568861bd4b8555936dbfeca4db82855e73</citedby><cites>FETCH-LOGICAL-c485t-6080169e64b7157f28e270d56607953568861bd4b8555936dbfeca4db82855e73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14939271$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12840643$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BURGOMASTER, Kirsten A</creatorcontrib><creatorcontrib>MOORE, Dan R</creatorcontrib><creatorcontrib>SCHOFIELD, Lee M</creatorcontrib><creatorcontrib>PHILLIPS, Stuart M</creatorcontrib><creatorcontrib>SALE, Digby G</creatorcontrib><creatorcontrib>GIBALA, Martin J</creatorcontrib><title>Resistance training with vascular occlusion: Metabolic adaptations in human muscle</title><title>Medicine and science in sports and exercise</title><addtitle>Med Sci Sports Exerc</addtitle><description>Two recent studies have reported increases in strength and whole muscle cross-sectional area after low-intensity resistance training (LIT) with vascular occlusion (OCC) that are greater than LIT alone (e.g., 22, 25). The OCC stress might be expected to induce metabolic alterations that are consistent with compromised oxygen delivery rather than an increase in strength per se, but this has not been studied.
We examined the effect of LIT and LIT+OCC on resting metabolites in m. biceps brachii and elbow flexor strength.
Eight men (19.5 +/- 0.4 yr) performed 8 wk of LIT at approximately 50% of one-repetition maximum (2 sessions per week; 3-6 sets, 8-10 repetitions, final set to failure); one arm trained with OCC and the other without (CON). :Biopsies obtained before and 72 h after the final training bout revealed that resting [glycogen] was higher (P <or= 0.05) in both arms after LIT (CON: 452 +/- 20 vs 325 +/- 28, OCC: 501 +/- 12 vs 332 +/- 28 mmol.kg-1 dry weight) and the increase was larger in the OCC arm (P <or= 0.05). Resting [ATP] was lower (P <or= 0.05) after LIT in both arms (CON: 20.5 +/- 0.5 vs 22.8 +/- 0.7, OCC: 18.2 +/- 0.6 vs 23.1 +/- 0.5 mmol.kg-1 dry weight), and the decrease was larger in the OCC arm (P <or= 0.05). Maximal isotonic and isokinetic elbow flexor strength increased (P <or= 0.05) after training to a similar extent in both arms.
We conclude that [glycogen] was increased and [ATP] was decreased in resting human muscle, 72 h after an 8-wk LIT protocol. OCC potentiated the metabolic changes, perhaps by inducing an ischemic stimulus that enhanced muscle glucose transport and adenine nucleotide catabolism after LIT, but did not augment the increases in strength.</description><subject>Adaptation, Physiological</subject><subject>Adenosine Triphosphate - metabolism</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Arm - blood supply</subject><subject>Arm - physiology</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiology. Vascular system</subject><subject>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</subject><subject>Exercise - physiology</subject><subject>Glucose - metabolism</subject><subject>Humans</subject><subject>Ischemia</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Muscle Fatigue</subject><subject>Muscle, Skeletal - blood supply</subject><subject>Muscle, Skeletal - physiology</subject><subject>Regional Blood Flow</subject><subject>Space life sciences</subject><subject>Weight Lifting</subject><issn>0195-9131</issn><issn>1530-0315</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkNtKxDAQhoMo7rr6ChIEveuaaY7dO1k8wYrg4TqkaaqRHtamVXx7s25hL52LGfj5ZgY-hM6AzCFl2SWB-cPz85xsSjLG1VwCSXnse2gKnJKEUOD7aEog40kGFCboKISPDU4pHKIJpIoRwegUPT254ENvGutw3xnf-OYNf_v-HX-ZYIfKdLi1thqCb5sFfnC9ydvKW2wKs-5NH9OAfYPfh9o0uB6CrdwxOihNFdzJOGfo9eb6ZXmXrB5v75dXq8QyxftEEEVAZE6wXAKXZapcKknBhSAy45QLpQTkBcsV5zyjoshLZw0rcpXGxEk6Qxfbu-uu_Rxc6HXtg3VVZRrXDkFLyqiQQvwLglJAJKcRXGxB27UhdK7U687XpvvRQPRGvSago3q9U6__1Mcel0_HL0Neu2K3OrqOwPkIRLOmKrso3YcdxzKapfHQL8eLi_Q</recordid><startdate>20030701</startdate><enddate>20030701</enddate><creator>BURGOMASTER, Kirsten A</creator><creator>MOORE, Dan R</creator><creator>SCHOFIELD, Lee M</creator><creator>PHILLIPS, Stuart M</creator><creator>SALE, Digby G</creator><creator>GIBALA, Martin J</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>7X8</scope></search><sort><creationdate>20030701</creationdate><title>Resistance training with vascular occlusion: Metabolic adaptations in human muscle</title><author>BURGOMASTER, Kirsten A ; MOORE, Dan R ; SCHOFIELD, Lee M ; PHILLIPS, Stuart M ; SALE, Digby G ; GIBALA, Martin J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c485t-6080169e64b7157f28e270d56607953568861bd4b8555936dbfeca4db82855e73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Adaptation, Physiological</topic><topic>Adenosine Triphosphate - metabolism</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Arm - blood supply</topic><topic>Arm - physiology</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Cardiology. Vascular system</topic><topic>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</topic><topic>Exercise - physiology</topic><topic>Glucose - metabolism</topic><topic>Humans</topic><topic>Ischemia</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Muscle Fatigue</topic><topic>Muscle, Skeletal - blood supply</topic><topic>Muscle, Skeletal - physiology</topic><topic>Regional Blood Flow</topic><topic>Space life sciences</topic><topic>Weight Lifting</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BURGOMASTER, Kirsten A</creatorcontrib><creatorcontrib>MOORE, Dan R</creatorcontrib><creatorcontrib>SCHOFIELD, Lee M</creatorcontrib><creatorcontrib>PHILLIPS, Stuart M</creatorcontrib><creatorcontrib>SALE, Digby G</creatorcontrib><creatorcontrib>GIBALA, Martin J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>MEDLINE - Academic</collection><jtitle>Medicine and science in sports and exercise</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BURGOMASTER, Kirsten A</au><au>MOORE, Dan R</au><au>SCHOFIELD, Lee M</au><au>PHILLIPS, Stuart M</au><au>SALE, Digby G</au><au>GIBALA, Martin J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Resistance training with vascular occlusion: Metabolic adaptations in human muscle</atitle><jtitle>Medicine and science in sports and exercise</jtitle><addtitle>Med Sci Sports Exerc</addtitle><date>2003-07-01</date><risdate>2003</risdate><volume>35</volume><issue>7</issue><spage>1203</spage><epage>1208</epage><pages>1203-1208</pages><issn>0195-9131</issn><eissn>1530-0315</eissn><coden>MSPEDA</coden><abstract>Two recent studies have reported increases in strength and whole muscle cross-sectional area after low-intensity resistance training (LIT) with vascular occlusion (OCC) that are greater than LIT alone (e.g., 22, 25). The OCC stress might be expected to induce metabolic alterations that are consistent with compromised oxygen delivery rather than an increase in strength per se, but this has not been studied.
We examined the effect of LIT and LIT+OCC on resting metabolites in m. biceps brachii and elbow flexor strength.
Eight men (19.5 +/- 0.4 yr) performed 8 wk of LIT at approximately 50% of one-repetition maximum (2 sessions per week; 3-6 sets, 8-10 repetitions, final set to failure); one arm trained with OCC and the other without (CON). :Biopsies obtained before and 72 h after the final training bout revealed that resting [glycogen] was higher (P <or= 0.05) in both arms after LIT (CON: 452 +/- 20 vs 325 +/- 28, OCC: 501 +/- 12 vs 332 +/- 28 mmol.kg-1 dry weight) and the increase was larger in the OCC arm (P <or= 0.05). Resting [ATP] was lower (P <or= 0.05) after LIT in both arms (CON: 20.5 +/- 0.5 vs 22.8 +/- 0.7, OCC: 18.2 +/- 0.6 vs 23.1 +/- 0.5 mmol.kg-1 dry weight), and the decrease was larger in the OCC arm (P <or= 0.05). Maximal isotonic and isokinetic elbow flexor strength increased (P <or= 0.05) after training to a similar extent in both arms.
We conclude that [glycogen] was increased and [ATP] was decreased in resting human muscle, 72 h after an 8-wk LIT protocol. OCC potentiated the metabolic changes, perhaps by inducing an ischemic stimulus that enhanced muscle glucose transport and adenine nucleotide catabolism after LIT, but did not augment the increases in strength.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>12840643</pmid><doi>10.1249/01.MSS.0000074458.71025.71</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Medicine and science in sports and exercise, 2003-07, Vol.35 (7), p.1203-1208 |
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| language | eng |
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| source | Journals@Ovid Ovid Autoload; MEDLINE; Journals@Ovid LWW Legacy Archive |
| subjects | Adaptation, Physiological Adenosine Triphosphate - metabolism Adolescent Adult Arm - blood supply Arm - physiology Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Exercise - physiology Glucose - metabolism Humans Ischemia Male Medical sciences Muscle Fatigue Muscle, Skeletal - blood supply Muscle, Skeletal - physiology Regional Blood Flow Space life sciences Weight Lifting |
| title | Resistance training with vascular occlusion: Metabolic adaptations in human muscle |
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