Independent Risk Factors for Carriage of Penicillin-non-susceptible Streptococcus pneumoniae
Antibiotic treatment, day-care center (DCC) attendance and young age are associated with penicillin-non-susceptible Streptococcus pneumoniae (PNSSp) carriage. Yet, it is unclear whether each is an independent risk factor for the individual. This cross-sectional surveillance study was designed to ans...
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| Veröffentlicht in: | Scandinavian journal of infectious diseases 2003, Vol.35 (4), p.219-222 |
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| container_title | Scandinavian journal of infectious diseases |
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| creator | Regev-yochay, Gili Raz, Meir Shainberg, Bracha Dagan, Ron Varon, Miriam Dushenat, Marina Rubinstein, Ethan |
| description | Antibiotic treatment, day-care center (DCC) attendance and young age are associated with penicillin-non-susceptible Streptococcus pneumoniae (PNSSp) carriage. Yet, it is unclear whether each is an independent risk factor for the individual. This cross-sectional surveillance study was designed to answer this question. Nasopharyngeal cultures were obtained from 429 children ( |
| doi_str_mv | 10.1080/00365540310000319 |
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Yet, it is unclear whether each is an independent risk factor for the individual. This cross-sectional surveillance study was designed to answer this question. Nasopharyngeal cultures were obtained from 429 children (<6 y) during a visit to the pediatrician's office. Two risk rates were calculated: the individual's absolute risk to carry PNSSp [simple odds ratio (ORS)] and the risk of an individual who is already a carrier [conditional odds ratio (ORC)]. Streptococcus pneumoniae was isolated from 52.7% of 401 children. PNSSp was detected in 37.1% of carriers. Independent risk factors were: young age [ORS 2.24, 95% confidence interval (95% CI) 1.2-4.2], DCC attendance (ORS 3.8, 95% CI 1.9-7.5), having young siblings (ORS 2.3, 95% CI 0.95-5.57) and each antibiotic treatment during the previous 3 months (ORS 1.5, 95% CI 1.25-1.85). The only significant risk factor among carriers was prior antibiotic treatment (ORC 2.24, 95% CI 1.64-3.05). Young children, who attended DCC and received 1 antibiotic course (9% of the population) had a risk 12.9 times higher than children without these features.</description><identifier>ISSN: 0036-5548</identifier><identifier>EISSN: 1651-1980</identifier><identifier>DOI: 10.1080/00365540310000319</identifier><identifier>PMID: 12839146</identifier><identifier>CODEN: SJIDB7</identifier><language>eng</language><publisher>Basingstoke: Informa UK Ltd</publisher><subject>Age Distribution ; Anti-Bacterial Agents - pharmacology ; Bacterial diseases ; Biological and medical sciences ; Carrier State ; Child ; Child Day Care Centers ; Child, Preschool ; Confidence Intervals ; Cross-Sectional Studies ; Female ; Human bacterial diseases ; Humans ; Incidence ; Infant ; Infectious diseases ; Israel - epidemiology ; Male ; Medical sciences ; Microbial Sensitivity Tests ; Multivariate Analysis ; Nasopharynx - microbiology ; Odds Ratio ; Penicillin Resistance ; Pneumococcal Infections - diagnosis ; Pneumococcal Infections - epidemiology ; Probability ; Risk Factors ; Sex Distribution ; Staphylococcal infections, streptococcal infections, pneumococcal infections ; Streptococcus pneumoniae - drug effects ; Streptococcus pneumoniae - isolation & purification</subject><ispartof>Scandinavian journal of infectious diseases, 2003, Vol.35 (4), p.219-222</ispartof><rights>2003 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2003</rights><rights>2003 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c463t-4f06ec83e35aa9b02d95de739c04982490a22fd3eb0a1c52b998a177f94dafc83</citedby><cites>FETCH-LOGICAL-c463t-4f06ec83e35aa9b02d95de739c04982490a22fd3eb0a1c52b998a177f94dafc83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/00365540310000319$$EPDF$$P50$$Ginformaworld$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/00365540310000319$$EHTML$$P50$$Ginformaworld$$H</linktohtml><link.rule.ids>314,778,782,4012,27906,27907,27908,59628,59734,60417,60523,61202,61237,61383,61418</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14873481$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12839146$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Regev-yochay, Gili</creatorcontrib><creatorcontrib>Raz, Meir</creatorcontrib><creatorcontrib>Shainberg, Bracha</creatorcontrib><creatorcontrib>Dagan, Ron</creatorcontrib><creatorcontrib>Varon, Miriam</creatorcontrib><creatorcontrib>Dushenat, Marina</creatorcontrib><creatorcontrib>Rubinstein, Ethan</creatorcontrib><title>Independent Risk Factors for Carriage of Penicillin-non-susceptible Streptococcus pneumoniae</title><title>Scandinavian journal of infectious diseases</title><addtitle>Scand J Infect Dis</addtitle><description>Antibiotic treatment, day-care center (DCC) attendance and young age are associated with penicillin-non-susceptible Streptococcus pneumoniae (PNSSp) carriage. Yet, it is unclear whether each is an independent risk factor for the individual. This cross-sectional surveillance study was designed to answer this question. Nasopharyngeal cultures were obtained from 429 children (<6 y) during a visit to the pediatrician's office. Two risk rates were calculated: the individual's absolute risk to carry PNSSp [simple odds ratio (ORS)] and the risk of an individual who is already a carrier [conditional odds ratio (ORC)]. Streptococcus pneumoniae was isolated from 52.7% of 401 children. PNSSp was detected in 37.1% of carriers. Independent risk factors were: young age [ORS 2.24, 95% confidence interval (95% CI) 1.2-4.2], DCC attendance (ORS 3.8, 95% CI 1.9-7.5), having young siblings (ORS 2.3, 95% CI 0.95-5.57) and each antibiotic treatment during the previous 3 months (ORS 1.5, 95% CI 1.25-1.85). The only significant risk factor among carriers was prior antibiotic treatment (ORC 2.24, 95% CI 1.64-3.05). Young children, who attended DCC and received 1 antibiotic course (9% of the population) had a risk 12.9 times higher than children without these features.</description><subject>Age Distribution</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Bacterial diseases</subject><subject>Biological and medical sciences</subject><subject>Carrier State</subject><subject>Child</subject><subject>Child Day Care Centers</subject><subject>Child, Preschool</subject><subject>Confidence Intervals</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Incidence</subject><subject>Infant</subject><subject>Infectious diseases</subject><subject>Israel - epidemiology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Microbial Sensitivity Tests</subject><subject>Multivariate Analysis</subject><subject>Nasopharynx - microbiology</subject><subject>Odds Ratio</subject><subject>Penicillin Resistance</subject><subject>Pneumococcal Infections - diagnosis</subject><subject>Pneumococcal Infections - epidemiology</subject><subject>Probability</subject><subject>Risk Factors</subject><subject>Sex Distribution</subject><subject>Staphylococcal infections, streptococcal infections, pneumococcal infections</subject><subject>Streptococcus pneumoniae - drug effects</subject><subject>Streptococcus pneumoniae - isolation & purification</subject><issn>0036-5548</issn><issn>1651-1980</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1LHTEUhkOp1KvtD-imzMbuRpNJZm6CbsrFLxCUfuwKw5nMSY1mkjGZQfz3Ru4VEcFmkQTyPIc35xDyldF9RiU9oJQ3dS0oZzQvztQHsmBNzUqmJP1IFk_vZQbkNtlJ6SYzouH0E9lmleSKiWZB_p77HkfMm5-KnzbdFiegpxBTYUIsVhCjhX9YBFNcobfaOmd96YMv05w0jpPtHBa_ppivQQet51SMHucheAv4mWwZcAm_bM5d8ufk-PfqrLy4PD1f_bgodc4zlcLQBrXkyGsA1dGqV3WPS640FUpWQlGoKtNz7CgwXVedUhLYcmmU6MFkcZd8X9cdY7ibMU3tYHM658BjmFO75ILzLPwXZFJSVtV1Btka1DGkFNG0Y7QDxIeW0fap9-2b3mfn26b43A3YvxibZmdgbwNA0uBMBK9teuGEzEEly9zRmrM-D2GA-xBd307w4EJ8lvh7OQ5f6dcIbrrWELG9CXP0eRLv_OIRdtWxWg</recordid><startdate>2003</startdate><enddate>2003</enddate><creator>Regev-yochay, Gili</creator><creator>Raz, Meir</creator><creator>Shainberg, Bracha</creator><creator>Dagan, Ron</creator><creator>Varon, Miriam</creator><creator>Dushenat, Marina</creator><creator>Rubinstein, Ethan</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>2003</creationdate><title>Independent Risk Factors for Carriage of Penicillin-non-susceptible Streptococcus pneumoniae</title><author>Regev-yochay, Gili ; Raz, Meir ; Shainberg, Bracha ; Dagan, Ron ; Varon, Miriam ; Dushenat, Marina ; Rubinstein, Ethan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c463t-4f06ec83e35aa9b02d95de739c04982490a22fd3eb0a1c52b998a177f94dafc83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Age Distribution</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Bacterial diseases</topic><topic>Biological and medical sciences</topic><topic>Carrier State</topic><topic>Child</topic><topic>Child Day Care Centers</topic><topic>Child, Preschool</topic><topic>Confidence Intervals</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Human bacterial diseases</topic><topic>Humans</topic><topic>Incidence</topic><topic>Infant</topic><topic>Infectious diseases</topic><topic>Israel - epidemiology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Microbial Sensitivity Tests</topic><topic>Multivariate Analysis</topic><topic>Nasopharynx - microbiology</topic><topic>Odds Ratio</topic><topic>Penicillin Resistance</topic><topic>Pneumococcal Infections - diagnosis</topic><topic>Pneumococcal Infections - epidemiology</topic><topic>Probability</topic><topic>Risk Factors</topic><topic>Sex Distribution</topic><topic>Staphylococcal infections, streptococcal infections, pneumococcal infections</topic><topic>Streptococcus pneumoniae - drug effects</topic><topic>Streptococcus pneumoniae - isolation & purification</topic><toplevel>online_resources</toplevel><creatorcontrib>Regev-yochay, Gili</creatorcontrib><creatorcontrib>Raz, Meir</creatorcontrib><creatorcontrib>Shainberg, Bracha</creatorcontrib><creatorcontrib>Dagan, Ron</creatorcontrib><creatorcontrib>Varon, Miriam</creatorcontrib><creatorcontrib>Dushenat, Marina</creatorcontrib><creatorcontrib>Rubinstein, Ethan</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Scandinavian journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Regev-yochay, Gili</au><au>Raz, Meir</au><au>Shainberg, Bracha</au><au>Dagan, Ron</au><au>Varon, Miriam</au><au>Dushenat, Marina</au><au>Rubinstein, Ethan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Independent Risk Factors for Carriage of Penicillin-non-susceptible Streptococcus pneumoniae</atitle><jtitle>Scandinavian journal of infectious diseases</jtitle><addtitle>Scand J Infect Dis</addtitle><date>2003</date><risdate>2003</risdate><volume>35</volume><issue>4</issue><spage>219</spage><epage>222</epage><pages>219-222</pages><issn>0036-5548</issn><eissn>1651-1980</eissn><coden>SJIDB7</coden><abstract>Antibiotic treatment, day-care center (DCC) attendance and young age are associated with penicillin-non-susceptible Streptococcus pneumoniae (PNSSp) carriage. Yet, it is unclear whether each is an independent risk factor for the individual. This cross-sectional surveillance study was designed to answer this question. Nasopharyngeal cultures were obtained from 429 children (<6 y) during a visit to the pediatrician's office. Two risk rates were calculated: the individual's absolute risk to carry PNSSp [simple odds ratio (ORS)] and the risk of an individual who is already a carrier [conditional odds ratio (ORC)]. Streptococcus pneumoniae was isolated from 52.7% of 401 children. PNSSp was detected in 37.1% of carriers. Independent risk factors were: young age [ORS 2.24, 95% confidence interval (95% CI) 1.2-4.2], DCC attendance (ORS 3.8, 95% CI 1.9-7.5), having young siblings (ORS 2.3, 95% CI 0.95-5.57) and each antibiotic treatment during the previous 3 months (ORS 1.5, 95% CI 1.25-1.85). The only significant risk factor among carriers was prior antibiotic treatment (ORC 2.24, 95% CI 1.64-3.05). Young children, who attended DCC and received 1 antibiotic course (9% of the population) had a risk 12.9 times higher than children without these features.</abstract><cop>Basingstoke</cop><pub>Informa UK Ltd</pub><pmid>12839146</pmid><doi>10.1080/00365540310000319</doi><tpages>4</tpages></addata></record> |
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| ispartof | Scandinavian journal of infectious diseases, 2003, Vol.35 (4), p.219-222 |
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| source | MEDLINE; Taylor & Francis Medical Library - CRKN; Taylor & Francis Journals Complete |
| subjects | Age Distribution Anti-Bacterial Agents - pharmacology Bacterial diseases Biological and medical sciences Carrier State Child Child Day Care Centers Child, Preschool Confidence Intervals Cross-Sectional Studies Female Human bacterial diseases Humans Incidence Infant Infectious diseases Israel - epidemiology Male Medical sciences Microbial Sensitivity Tests Multivariate Analysis Nasopharynx - microbiology Odds Ratio Penicillin Resistance Pneumococcal Infections - diagnosis Pneumococcal Infections - epidemiology Probability Risk Factors Sex Distribution Staphylococcal infections, streptococcal infections, pneumococcal infections Streptococcus pneumoniae - drug effects Streptococcus pneumoniae - isolation & purification |
| title | Independent Risk Factors for Carriage of Penicillin-non-susceptible Streptococcus pneumoniae |
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