Her2/neu expression in cancer: the pathologist as diagnostician or prophet?

Following its identification, much of the original work on HER2/neu was performed on the breast where this gene is amplified and/or overexpressed in 20% to 30% of carcinomas.4,5 In all of the cancers, HER2/neu gene-expression is usually associated with tumor aggressiveness and poor prognosis.7,8 In...

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