Monoamine levels in rat striatum after acute intraperitoneal injection of strictosidinic acid isolated from Psychotria myriantha Mull. Arg. (Rubiaceae)
Strictosidinic acid 10 mg/kg, isolated from Psychotria myriantha leaves, were administered intraperitoneally to Wistar male rats (n=5-6). After 60 minutes, striatum was dissected, homogenized and injected onto HPLC-ED chromatographic system. It was observed a 28.7% reduction in the 5-HT levels follo...
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| Veröffentlicht in: | Phytomedicine (Stuttgart) 2010-03, Vol.17 (3), p.289-291 |
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| creator | Farias, F.M. Passos, C.S. Arbo, M.D. Zuanazzi, J.A.S. Steffen, V.M. Henriques, A.T. |
| description | Strictosidinic acid 10
mg/kg, isolated from
Psychotria myriantha leaves, were administered intraperitoneally to Wistar male rats (n=5-6). After 60
minutes, striatum was dissected, homogenized and injected onto HPLC-ED chromatographic system. It was observed a 28.7% reduction in the 5-HT levels followed up by an increase of 5-HIAA levels (29.4%). Furthermore there was a decrease of 8.0% in DA levels and an increase in the levels of metabolites DOPAC (21.5%) and HVA (52.5%). The results indicate that strictosidinic acid has a promising effect in the central nervous system, justifying more studies about the central actions of
Psychotria compounds. |
| doi_str_mv | 10.1016/j.phymed.2009.05.008 |
| format | Article |
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mg/kg, isolated from
Psychotria myriantha leaves, were administered intraperitoneally to Wistar male rats (n=5-6). After 60
minutes, striatum was dissected, homogenized and injected onto HPLC-ED chromatographic system. It was observed a 28.7% reduction in the 5-HT levels followed up by an increase of 5-HIAA levels (29.4%). Furthermore there was a decrease of 8.0% in DA levels and an increase in the levels of metabolites DOPAC (21.5%) and HVA (52.5%). The results indicate that strictosidinic acid has a promising effect in the central nervous system, justifying more studies about the central actions of
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mg/kg, isolated from
Psychotria myriantha leaves, were administered intraperitoneally to Wistar male rats (n=5-6). After 60
minutes, striatum was dissected, homogenized and injected onto HPLC-ED chromatographic system. It was observed a 28.7% reduction in the 5-HT levels followed up by an increase of 5-HIAA levels (29.4%). Furthermore there was a decrease of 8.0% in DA levels and an increase in the levels of metabolites DOPAC (21.5%) and HVA (52.5%). The results indicate that strictosidinic acid has a promising effect in the central nervous system, justifying more studies about the central actions of
Psychotria compounds.</description><subject>3,4-Dihydroxyphenylacetic Acid - metabolism</subject><subject>Alkaloids</subject><subject>Animals</subject><subject>Carbolines - isolation & purification</subject><subject>Carbolines - pharmacology</subject><subject>Corpus Striatum - drug effects</subject><subject>Corpus Striatum - metabolism</subject><subject>Dopamine - metabolism</subject><subject>Glycosides - isolation & purification</subject><subject>Glycosides - pharmacology</subject><subject>Health aspects</subject><subject>Homovanillic Acid - metabolism</subject><subject>Injections, Intraperitoneal</subject><subject>Male</subject><subject>Metabolites</subject><subject>Migraine</subject><subject>Monoamine levels</subject><subject>Neurotransmitter Agents - administration & dosage</subject><subject>Neurotransmitter Agents - isolation & purification</subject><subject>Neurotransmitter Agents - pharmacology</subject><subject>Phenylacetates - metabolism</subject><subject>Plant Extracts - administration & dosage</subject><subject>Plant Extracts - chemistry</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Leaves</subject><subject>Psychotria myriantha</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Rubiaceae - chemistry</subject><subject>Serotonin - analogs & derivatives</subject><subject>Serotonin - metabolism</subject><subject>Striatum</subject><subject>Strictosidinic acid</subject><issn>0944-7113</issn><issn>1618-095X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9ktGK1DAUhoso7uzqG4gEvFAvWpM2bZobYVhcFXZRRMG7kElOZzKkyWySLsyT-LqmdhCEQQIJJ-f7Tzgnf1G8ILgimHTv9tVhdxxBVzXGvMJthXH_qFiRjvQl5u3Px8UKc0pLRkhzUVzGuMeYUM7w0-KC8JZ1rOGr4tedd16OxgGy8AA2IuNQkAnFFIxM04jkkCAgqaYEOZeCPEAwyTuQNsd7UMl4h_zwR6GSj0YbZ1RWGI1M9FYm0GgIfkRf41Ht_FwYjce8u7ST6G6ytkLrsK3Qm2_TxkgFEt4-K54M0kZ4fjqvih83H75ffypvv3z8fL2-LRXtulR2asNbrHtZt2xoMaaSk41mvdK9Vl3PVM0Uq-ueUtbpgUjJMOVq01HKcVOTtrkqXi91D8HfTxCTGE1UYK104KcoWENrnsfWZ_LVQm6lBWHckBuRaqbFuq67pq_bnmeqPENtwUGQNg9tMPn6H746w-elYTTqrIAuAhV8jAEGcQhmlOEoCBazMcReLMYQszEEbkU2Rpa9PPU5bebcX9HJCRl4vwDZA_BgIIioDDgF2oT8x0J78_8XfgM0ysxE</recordid><startdate>20100301</startdate><enddate>20100301</enddate><creator>Farias, F.M.</creator><creator>Passos, C.S.</creator><creator>Arbo, M.D.</creator><creator>Zuanazzi, J.A.S.</creator><creator>Steffen, V.M.</creator><creator>Henriques, A.T.</creator><general>Elsevier GmbH</general><general>Urban & Fischer Verlag</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20100301</creationdate><title>Monoamine levels in rat striatum after acute intraperitoneal injection of strictosidinic acid isolated from Psychotria myriantha Mull. Arg. (Rubiaceae)</title><author>Farias, F.M. ; Passos, C.S. ; Arbo, M.D. ; Zuanazzi, J.A.S. ; Steffen, V.M. ; Henriques, A.T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c466t-6cb950d8a257f5004a91bd78cd8dc687c27c72284476df1aa7049cb6449032153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>3,4-Dihydroxyphenylacetic Acid - metabolism</topic><topic>Alkaloids</topic><topic>Animals</topic><topic>Carbolines - isolation & purification</topic><topic>Carbolines - pharmacology</topic><topic>Corpus Striatum - drug effects</topic><topic>Corpus Striatum - metabolism</topic><topic>Dopamine - metabolism</topic><topic>Glycosides - isolation & purification</topic><topic>Glycosides - pharmacology</topic><topic>Health aspects</topic><topic>Homovanillic Acid - metabolism</topic><topic>Injections, Intraperitoneal</topic><topic>Male</topic><topic>Metabolites</topic><topic>Migraine</topic><topic>Monoamine levels</topic><topic>Neurotransmitter Agents - administration & dosage</topic><topic>Neurotransmitter Agents - isolation & purification</topic><topic>Neurotransmitter Agents - pharmacology</topic><topic>Phenylacetates - metabolism</topic><topic>Plant Extracts - administration & dosage</topic><topic>Plant Extracts - chemistry</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Leaves</topic><topic>Psychotria myriantha</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Rubiaceae - chemistry</topic><topic>Serotonin - analogs & derivatives</topic><topic>Serotonin - metabolism</topic><topic>Striatum</topic><topic>Strictosidinic acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Farias, F.M.</creatorcontrib><creatorcontrib>Passos, C.S.</creatorcontrib><creatorcontrib>Arbo, M.D.</creatorcontrib><creatorcontrib>Zuanazzi, J.A.S.</creatorcontrib><creatorcontrib>Steffen, V.M.</creatorcontrib><creatorcontrib>Henriques, A.T.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Phytomedicine (Stuttgart)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Farias, F.M.</au><au>Passos, C.S.</au><au>Arbo, M.D.</au><au>Zuanazzi, J.A.S.</au><au>Steffen, V.M.</au><au>Henriques, A.T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Monoamine levels in rat striatum after acute intraperitoneal injection of strictosidinic acid isolated from Psychotria myriantha Mull. Arg. (Rubiaceae)</atitle><jtitle>Phytomedicine (Stuttgart)</jtitle><addtitle>Phytomedicine</addtitle><date>2010-03-01</date><risdate>2010</risdate><volume>17</volume><issue>3</issue><spage>289</spage><epage>291</epage><pages>289-291</pages><issn>0944-7113</issn><eissn>1618-095X</eissn><abstract>Strictosidinic acid 10
mg/kg, isolated from
Psychotria myriantha leaves, were administered intraperitoneally to Wistar male rats (n=5-6). After 60
minutes, striatum was dissected, homogenized and injected onto HPLC-ED chromatographic system. It was observed a 28.7% reduction in the 5-HT levels followed up by an increase of 5-HIAA levels (29.4%). Furthermore there was a decrease of 8.0% in DA levels and an increase in the levels of metabolites DOPAC (21.5%) and HVA (52.5%). The results indicate that strictosidinic acid has a promising effect in the central nervous system, justifying more studies about the central actions of
Psychotria compounds.</abstract><cop>Germany</cop><pub>Elsevier GmbH</pub><pmid>19576739</pmid><doi>10.1016/j.phymed.2009.05.008</doi><tpages>3</tpages></addata></record> |
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| subjects | 3,4-Dihydroxyphenylacetic Acid - metabolism Alkaloids Animals Carbolines - isolation & purification Carbolines - pharmacology Corpus Striatum - drug effects Corpus Striatum - metabolism Dopamine - metabolism Glycosides - isolation & purification Glycosides - pharmacology Health aspects Homovanillic Acid - metabolism Injections, Intraperitoneal Male Metabolites Migraine Monoamine levels Neurotransmitter Agents - administration & dosage Neurotransmitter Agents - isolation & purification Neurotransmitter Agents - pharmacology Phenylacetates - metabolism Plant Extracts - administration & dosage Plant Extracts - chemistry Plant Extracts - pharmacology Plant Leaves Psychotria myriantha Rats Rats, Wistar Rubiaceae - chemistry Serotonin - analogs & derivatives Serotonin - metabolism Striatum Strictosidinic acid |
| title | Monoamine levels in rat striatum after acute intraperitoneal injection of strictosidinic acid isolated from Psychotria myriantha Mull. Arg. (Rubiaceae) |
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