Role of nuclear and cytoplasmic localization in the tumour-suppressor activity of the von Hippel-Lindau protein

Mutations in the von Hippel-Lindau (VHL) tumour-suppressor gene result in several forms of cancer. In the present study, we investigated the role of VHL subcellular localization in its antitumour properties. We generated renal cell carcinoma (RCC) lines stably expressing either exclusively nuclear (...

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Veröffentlicht in:	Oncogene 2003-06, Vol.22 (26), p.3992-3997
Hauptverfasser:	Lewis, Martin D, Roberts, Ben J
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Apoptosis Bacterial Proteins - metabolism Biological and medical sciences Carcinoma, Renal Cell - metabolism Cell Biology Cell cycle Cell Nucleus - metabolism Collagen - pharmacology Cytoplasm - metabolism Down-Regulation Drug Combinations Electrophoresis, Polyacrylamide Gel Fibronectins - metabolism Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Neoplastic Genetic Vectors Glucose Transporter Type 1 Human Genetics Humans Hypoxia-Inducible Factor 1, alpha Subunit Integrin alpha5 - metabolism Internal Medicine Kidney cancer Kidney Neoplasms - metabolism Laminin - pharmacology Ligases - metabolism Localization Luminescent Proteins - metabolism Medicine Medicine & Public Health Microscopy, Fluorescence Molecular and cellular biology Molecular Sequence Data Monosaccharide Transport Proteins - metabolism Mutation Oncology original-paper Protein Structure, Tertiary Proteins Proteoglycans - pharmacology Recombinant Proteins - metabolism Renal cell carcinoma Transcription Factors - metabolism Tumor Cells, Cultured Tumor Suppressor Proteins Tumorigenesis Tumors Ubiquitin-Protein Ligases VHL protein Von Hippel-Lindau Tumor Suppressor Protein
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