Acid Extrusion from Human Spermatozoa Is Mediated by Flagellar Voltage-Gated Proton Channel

Human spermatozoa are quiescent in the male reproductive system and must undergo activation once introduced into the female reproductive tract. This process is known to require alkalinization of sperm cytoplasm, but the mechanism responsible for transmembrane proton extrusion has remained unknown be...

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Veröffentlicht in:	Cell 2010-02, Vol.140 (3), p.327-337
Hauptverfasser:	Lishko, Polina V., Botchkina, Inna L., Fedorenko, Andriy, Kirichok, Yuriy
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrosome Reaction Animals DEVBIO Female Humans HUMDISEASE Hydrogen-Ion Concentration Ion Channels - antagonists & inhibitors Ion Channels - metabolism Male Mice SIGNALING Sperm Capacitation Sperm Motility Sperm Tail - metabolism Spermatozoa - cytology Spermatozoa - metabolism
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