Nicotinamide - biologic actions of an emerging cosmetic ingredient
Synopsis Nicotinamide, the water‐soluble amide of nicotinic acid, is a component of the two most important coenzymes – nicotinamide adenine dinucleotide and nicotinamide adenine dinucleotide phosphate. Thus nicotinamide is involved in numerous oxidation–reduction reactions in mammalian biological sy...
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Veröffentlicht in: | International journal of cosmetic science 2005-10, Vol.27 (5), p.255-261 |
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description | Synopsis
Nicotinamide, the water‐soluble amide of nicotinic acid, is a component of the two most important coenzymes – nicotinamide adenine dinucleotide and nicotinamide adenine dinucleotide phosphate. Thus nicotinamide is involved in numerous oxidation–reduction reactions in mammalian biological systems. Nicotinamide essentially acts as an antioxidant. Most effects are exerted via poly‐adenosine diphosphate‐ribose polymerase inhibition. Thus nicotinamide increasingly gains interest in the prevention and treatment of several skin diseases. It is well established in the systemic therapy of pellagra, a deficiency disease linked to nicotinic acid, but with respect to topical use there is still a need for further evidence with respect to its manifold potential uses. Currently, its local use is established in the care of acne‐prone skin.
Résumé
Le nicotinamide, l‘amide hydrosoluble de l'acide nicotinique est un composant des deux plus importants co‐enzymes NAD et NADP. Le nicotinamide est impliqué dans de nombreuses réactions d'oxydo‐réduction dans les systèmes biologiques des mammifères. Le nicotinamide agit essentiellement en tant qu'anti‐oxydant. La plupart des effets sont exercés via l'inhibition de la poly (ADP‐ribose) polymerase (PARP). Ainsi, l'intérêt du nicotinamide croît dans la prévention et le traitement de nombreuses maladies cutanées. Son rôle est bien établi dans la thérapie systémique de la pellagre, une maladie déficiente liée à l'acide nicotinique, mais en ce qui concerne son utilisation topique, du fait de ses multiples applications potentielles, il est encore nécessaire d'accumuler davantage de preuves. Son utilisation locale est couramment admise dans le traitement des peaux sujettes à l'acné. |
doi_str_mv | 10.1111/j.1467-2494.2005.00266.x |
format | Article |
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Nicotinamide, the water‐soluble amide of nicotinic acid, is a component of the two most important coenzymes – nicotinamide adenine dinucleotide and nicotinamide adenine dinucleotide phosphate. Thus nicotinamide is involved in numerous oxidation–reduction reactions in mammalian biological systems. Nicotinamide essentially acts as an antioxidant. Most effects are exerted via poly‐adenosine diphosphate‐ribose polymerase inhibition. Thus nicotinamide increasingly gains interest in the prevention and treatment of several skin diseases. It is well established in the systemic therapy of pellagra, a deficiency disease linked to nicotinic acid, but with respect to topical use there is still a need for further evidence with respect to its manifold potential uses. Currently, its local use is established in the care of acne‐prone skin.
Résumé
Le nicotinamide, l‘amide hydrosoluble de l'acide nicotinique est un composant des deux plus importants co‐enzymes NAD et NADP. Le nicotinamide est impliqué dans de nombreuses réactions d'oxydo‐réduction dans les systèmes biologiques des mammifères. Le nicotinamide agit essentiellement en tant qu'anti‐oxydant. La plupart des effets sont exercés via l'inhibition de la poly (ADP‐ribose) polymerase (PARP). Ainsi, l'intérêt du nicotinamide croît dans la prévention et le traitement de nombreuses maladies cutanées. Son rôle est bien établi dans la thérapie systémique de la pellagre, une maladie déficiente liée à l'acide nicotinique, mais en ce qui concerne son utilisation topique, du fait de ses multiples applications potentielles, il est encore nécessaire d'accumuler davantage de preuves. Son utilisation locale est couramment admise dans le traitement des peaux sujettes à l'acné.</description><identifier>ISSN: 0142-5463</identifier><identifier>EISSN: 1468-2494</identifier><identifier>DOI: 10.1111/j.1467-2494.2005.00266.x</identifier><identifier>PMID: 18492206</identifier><identifier>CODEN: IJCMDW</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science Ltd</publisher><subject>acne ; Biological and medical sciences ; ceramide synthesis ; coenzyme NAD ; coenzyme NADP ; Dermatology ; Diseases of the skin. Cosmetics ; inflammation ; Medical sciences ; PARP inhibition ; Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) ; skin disease ; Skin involvement in other diseases. Miscellaneous. General aspects</subject><ispartof>International journal of cosmetic science, 2005-10, Vol.27 (5), p.255-261</ispartof><rights>2006 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4166-7736e01e976bb0507db2d166ee60cf28d6f6971599f697273f57333d14f2bcf93</citedby><cites>FETCH-LOGICAL-c4166-7736e01e976bb0507db2d166ee60cf28d6f6971599f697273f57333d14f2bcf93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1467-2494.2005.00266.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1467-2494.2005.00266.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=17100911$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18492206$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Otte, N.</creatorcontrib><creatorcontrib>Borelli, C.</creatorcontrib><creatorcontrib>Korting, H. C.</creatorcontrib><title>Nicotinamide - biologic actions of an emerging cosmetic ingredient</title><title>International journal of cosmetic science</title><addtitle>Int J Cosmet Sci</addtitle><description>Synopsis
Nicotinamide, the water‐soluble amide of nicotinic acid, is a component of the two most important coenzymes – nicotinamide adenine dinucleotide and nicotinamide adenine dinucleotide phosphate. Thus nicotinamide is involved in numerous oxidation–reduction reactions in mammalian biological systems. Nicotinamide essentially acts as an antioxidant. Most effects are exerted via poly‐adenosine diphosphate‐ribose polymerase inhibition. Thus nicotinamide increasingly gains interest in the prevention and treatment of several skin diseases. It is well established in the systemic therapy of pellagra, a deficiency disease linked to nicotinic acid, but with respect to topical use there is still a need for further evidence with respect to its manifold potential uses. Currently, its local use is established in the care of acne‐prone skin.
Résumé
Le nicotinamide, l‘amide hydrosoluble de l'acide nicotinique est un composant des deux plus importants co‐enzymes NAD et NADP. Le nicotinamide est impliqué dans de nombreuses réactions d'oxydo‐réduction dans les systèmes biologiques des mammifères. Le nicotinamide agit essentiellement en tant qu'anti‐oxydant. La plupart des effets sont exercés via l'inhibition de la poly (ADP‐ribose) polymerase (PARP). Ainsi, l'intérêt du nicotinamide croît dans la prévention et le traitement de nombreuses maladies cutanées. Son rôle est bien établi dans la thérapie systémique de la pellagre, une maladie déficiente liée à l'acide nicotinique, mais en ce qui concerne son utilisation topique, du fait de ses multiples applications potentielles, il est encore nécessaire d'accumuler davantage de preuves. Son utilisation locale est couramment admise dans le traitement des peaux sujettes à l'acné.</description><subject>acne</subject><subject>Biological and medical sciences</subject><subject>ceramide synthesis</subject><subject>coenzyme NAD</subject><subject>coenzyme NADP</subject><subject>Dermatology</subject><subject>Diseases of the skin. Cosmetics</subject><subject>inflammation</subject><subject>Medical sciences</subject><subject>PARP inhibition</subject><subject>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</subject><subject>skin disease</subject><subject>Skin involvement in other diseases. Miscellaneous. General aspects</subject><issn>0142-5463</issn><issn>1468-2494</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2005</creationdate><recordtype>article</recordtype><recordid>eNqNkM1u1DAURq0K1E4Lr1BlU7FK8F_sWOoGprRUKgUEqN1ZjnM98pDErZ0R07fH6YzoFm-ure98tnUQKgiuSF7v1xXhQpaUK15RjOsKYypEtT1Aixw0z8ErtMCE07Lmgh2h45TWGGOuGnaIjkjDFaVYLNDHW2_D5Ecz-A6Ksmh96MPK28LYyYcxFcEVZixggLjy46qwIQ0w5TwfInQexukNeu1Mn-Dtfp6gX5effi4_lzdfr66XH25Ky4kQpZRMACagpGhbXGPZtbTLAYDA1tGmE04oSWql5kklc7VkjHWEO9pap9gJere79yGGxw2kSQ8-Weh7M0LYJC0Zpw2XtMlksyNtDClFcPoh-sHEJ02wngXqtZ4F6tmTngXqZ4F6m6un-0c27QDdS3FvLANne8Aka3oXzWh9euEkwVgRkrnzHffH9_D03x_Q18sfeZPr5a7u0wTbf3UTf2shmaz13e2V_vLtu7on6k5fsL9baZkf</recordid><startdate>200510</startdate><enddate>200510</enddate><creator>Otte, N.</creator><creator>Borelli, C.</creator><creator>Korting, H. C.</creator><general>Blackwell Science Ltd</general><general>Blackwell Science</general><scope>BSCLL</scope><scope>IQODW</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200510</creationdate><title>Nicotinamide - biologic actions of an emerging cosmetic ingredient</title><author>Otte, N. ; Borelli, C. ; Korting, H. C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4166-7736e01e976bb0507db2d166ee60cf28d6f6971599f697273f57333d14f2bcf93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2005</creationdate><topic>acne</topic><topic>Biological and medical sciences</topic><topic>ceramide synthesis</topic><topic>coenzyme NAD</topic><topic>coenzyme NADP</topic><topic>Dermatology</topic><topic>Diseases of the skin. Cosmetics</topic><topic>inflammation</topic><topic>Medical sciences</topic><topic>PARP inhibition</topic><topic>Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)</topic><topic>skin disease</topic><topic>Skin involvement in other diseases. Miscellaneous. General aspects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Otte, N.</creatorcontrib><creatorcontrib>Borelli, C.</creatorcontrib><creatorcontrib>Korting, H. C.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of cosmetic science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Otte, N.</au><au>Borelli, C.</au><au>Korting, H. C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nicotinamide - biologic actions of an emerging cosmetic ingredient</atitle><jtitle>International journal of cosmetic science</jtitle><addtitle>Int J Cosmet Sci</addtitle><date>2005-10</date><risdate>2005</risdate><volume>27</volume><issue>5</issue><spage>255</spage><epage>261</epage><pages>255-261</pages><issn>0142-5463</issn><eissn>1468-2494</eissn><coden>IJCMDW</coden><abstract>Synopsis
Nicotinamide, the water‐soluble amide of nicotinic acid, is a component of the two most important coenzymes – nicotinamide adenine dinucleotide and nicotinamide adenine dinucleotide phosphate. Thus nicotinamide is involved in numerous oxidation–reduction reactions in mammalian biological systems. Nicotinamide essentially acts as an antioxidant. Most effects are exerted via poly‐adenosine diphosphate‐ribose polymerase inhibition. Thus nicotinamide increasingly gains interest in the prevention and treatment of several skin diseases. It is well established in the systemic therapy of pellagra, a deficiency disease linked to nicotinic acid, but with respect to topical use there is still a need for further evidence with respect to its manifold potential uses. Currently, its local use is established in the care of acne‐prone skin.
Résumé
Le nicotinamide, l‘amide hydrosoluble de l'acide nicotinique est un composant des deux plus importants co‐enzymes NAD et NADP. Le nicotinamide est impliqué dans de nombreuses réactions d'oxydo‐réduction dans les systèmes biologiques des mammifères. Le nicotinamide agit essentiellement en tant qu'anti‐oxydant. La plupart des effets sont exercés via l'inhibition de la poly (ADP‐ribose) polymerase (PARP). Ainsi, l'intérêt du nicotinamide croît dans la prévention et le traitement de nombreuses maladies cutanées. Son rôle est bien établi dans la thérapie systémique de la pellagre, une maladie déficiente liée à l'acide nicotinique, mais en ce qui concerne son utilisation topique, du fait de ses multiples applications potentielles, il est encore nécessaire d'accumuler davantage de preuves. Son utilisation locale est couramment admise dans le traitement des peaux sujettes à l'acné.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science Ltd</pub><pmid>18492206</pmid><doi>10.1111/j.1467-2494.2005.00266.x</doi><tpages>7</tpages></addata></record> |
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subjects | acne Biological and medical sciences ceramide synthesis coenzyme NAD coenzyme NADP Dermatology Diseases of the skin. Cosmetics inflammation Medical sciences PARP inhibition Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) skin disease Skin involvement in other diseases. Miscellaneous. General aspects |
title | Nicotinamide - biologic actions of an emerging cosmetic ingredient |
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