Differential effects of anti-TNF-α drugs on fibroblast-like synoviocyte apoptosis

Objective. Novel drugs targeting TNF-α are available for treatment of RA. Fibroblast-like synoviocytes (FLSs) play a fundamental role in RA progression, through their expansion caused in part by resistance to cell death induction. The aim of our study was to determine the effects of different anti-T...

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Veröffentlicht in:	Rheumatology (Oxford, England) England), 2010-03, Vol.49 (3), p.480-489
Hauptverfasser:	Pattacini, Laura, Boiardi, Luigi, Casali, Bruno, Salvarani, Carlo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adalimumab Anoikis - drug effects Anti-TNF-α Antibodies, Monoclonal - pharmacology Antibodies, Monoclonal, Humanized Antirheumatic Agents - pharmacology Apoptosis Apoptosis - drug effects Arthritis, Rheumatoid - metabolism Arthritis, Rheumatoid - pathology Bcl-2 Biological and medical sciences Cell Communication - physiology Cell Survival - drug effects Cells, Cultured Coculture Techniques Diseases of the osteoarticular system Etanercept Fibroblast-like synoviocytes Fibroblasts - drug effects Fibroblasts - metabolism Humans Immunoglobulin G - pharmacology Infliximab Medical sciences Osteoarthritis, Knee - metabolism Osteoarthritis, Knee - pathology Proto-Oncogene Proteins c-bcl-2 - biosynthesis Receptors, Tumor Necrosis Factor Reverse signalling Synovial Membrane - drug effects Synovial Membrane - metabolism Synovial Membrane - pathology Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - biosynthesis Up-Regulation
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