Risk factors for idiopathic pulmonary fibrosis in a Mexican population. A case-control study
Summary The etiology of idiopathic pulmonary fibrosis (IPF) remains poorly understood, but some studies have suggested that cigarette smoking or other occupational or environmental exposures, diabetes mellitus, or gastroesophageal reflux may play a role. In this study we evaluated the clinical recor...
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| Veröffentlicht in: | Respiratory medicine 2010-02, Vol.104 (2), p.305-309 |
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| creator | García-Sancho Figueroa, Ma. Cecilia Carrillo, Guillermo Pérez-Padilla, Rogelio Fernández-Plata, Ma. Rosario Buendía-Roldán, Ivette Vargas, Mario H Selman, Moisés |
| description | Summary The etiology of idiopathic pulmonary fibrosis (IPF) remains poorly understood, but some studies have suggested that cigarette smoking or other occupational or environmental exposures, diabetes mellitus, or gastroesophageal reflux may play a role. In this study we evaluated the clinical records of a group of 97 consecutive patients with IPF, and 560 patients suffering 5 different respiratory disorders that were examined as controls: asthma ( n = 111), chronic obstructive pulmonary disease ( n = 132), squamous cell lung carcinoma ( n = 118), lung adenocarcinoma ( n = 101) and patients with otorhinolaryngology problems but without lung disease ( n = 98). In bivariate analyses male sex, diabetes mellitus and being former cigarette smoker were associated with IPF. After adjusting by these variables, multivariate analysis revealed that type 2 diabetes mellitus [11.3% in IPF patients vs 2.9% in controls, OR = 4.3 (95% CI: 1.9–9.8), p < 0.0001] was an independent risk factor associated to IPF. Our results provide additional evidence of a putative relationship between DM2 and idiopathic pulmonary fibrosis. Experimental research is necessary for thorough assessment of the pathogenic mechanisms involved in this association. |
| doi_str_mv | 10.1016/j.rmed.2009.08.013 |
| format | Article |
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A case-control study</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>García-Sancho Figueroa, Ma. Cecilia ; Carrillo, Guillermo ; Pérez-Padilla, Rogelio ; Fernández-Plata, Ma. Rosario ; Buendía-Roldán, Ivette ; Vargas, Mario H ; Selman, Moisés</creator><creatorcontrib>García-Sancho Figueroa, Ma. Cecilia ; Carrillo, Guillermo ; Pérez-Padilla, Rogelio ; Fernández-Plata, Ma. Rosario ; Buendía-Roldán, Ivette ; Vargas, Mario H ; Selman, Moisés</creatorcontrib><description>Summary The etiology of idiopathic pulmonary fibrosis (IPF) remains poorly understood, but some studies have suggested that cigarette smoking or other occupational or environmental exposures, diabetes mellitus, or gastroesophageal reflux may play a role. In this study we evaluated the clinical records of a group of 97 consecutive patients with IPF, and 560 patients suffering 5 different respiratory disorders that were examined as controls: asthma ( n = 111), chronic obstructive pulmonary disease ( n = 132), squamous cell lung carcinoma ( n = 118), lung adenocarcinoma ( n = 101) and patients with otorhinolaryngology problems but without lung disease ( n = 98). In bivariate analyses male sex, diabetes mellitus and being former cigarette smoker were associated with IPF. After adjusting by these variables, multivariate analysis revealed that type 2 diabetes mellitus [11.3% in IPF patients vs 2.9% in controls, OR = 4.3 (95% CI: 1.9–9.8), p < 0.0001] was an independent risk factor associated to IPF. Our results provide additional evidence of a putative relationship between DM2 and idiopathic pulmonary fibrosis. Experimental research is necessary for thorough assessment of the pathogenic mechanisms involved in this association.</description><identifier>ISSN: 0954-6111</identifier><identifier>EISSN: 1532-3064</identifier><identifier>DOI: 10.1016/j.rmed.2009.08.013</identifier><identifier>PMID: 19782552</identifier><language>eng</language><publisher>Kidlington: Elsevier Ltd</publisher><subject>Asthma ; Biological and medical sciences ; Carcinoma, Squamous Cell - complications ; Case-Control Studies ; Confidence intervals ; Diabetes mellitus ; Diabetes Mellitus, Type 2 - complications ; Diabetes. Impaired glucose tolerance ; Disease ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Female ; Gender ; Humans ; Idiopathic Pulmonary Fibrosis - etiology ; Infections ; Lung diseases ; Lung Neoplasms - complications ; Male ; Medical sciences ; Mexico ; Middle Aged ; Pneumology ; Prognosis ; Pulmonary fibrosis ; Pulmonary/Respiratory ; Questionnaires ; Respiratory system : syndromes and miscellaneous diseases ; Retrospective Studies ; Risk Factors ; Smoking - adverse effects ; Smoking cigarette ; Studies ; Tobacco smoke ; Tobacco, tobacco smoking ; Toxicology</subject><ispartof>Respiratory medicine, 2010-02, Vol.104 (2), p.305-309</ispartof><rights>Elsevier Ltd</rights><rights>2009 Elsevier Ltd</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c512t-9453241da10173ceb184dc41344b38c8508e010c728044d72287940eea90feb63</citedby><cites>FETCH-LOGICAL-c512t-9453241da10173ceb184dc41344b38c8508e010c728044d72287940eea90feb63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.rmed.2009.08.013$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22393443$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19782552$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>García-Sancho Figueroa, Ma. Cecilia</creatorcontrib><creatorcontrib>Carrillo, Guillermo</creatorcontrib><creatorcontrib>Pérez-Padilla, Rogelio</creatorcontrib><creatorcontrib>Fernández-Plata, Ma. Rosario</creatorcontrib><creatorcontrib>Buendía-Roldán, Ivette</creatorcontrib><creatorcontrib>Vargas, Mario H</creatorcontrib><creatorcontrib>Selman, Moisés</creatorcontrib><title>Risk factors for idiopathic pulmonary fibrosis in a Mexican population. A case-control study</title><title>Respiratory medicine</title><addtitle>Respir Med</addtitle><description>Summary The etiology of idiopathic pulmonary fibrosis (IPF) remains poorly understood, but some studies have suggested that cigarette smoking or other occupational or environmental exposures, diabetes mellitus, or gastroesophageal reflux may play a role. In this study we evaluated the clinical records of a group of 97 consecutive patients with IPF, and 560 patients suffering 5 different respiratory disorders that were examined as controls: asthma ( n = 111), chronic obstructive pulmonary disease ( n = 132), squamous cell lung carcinoma ( n = 118), lung adenocarcinoma ( n = 101) and patients with otorhinolaryngology problems but without lung disease ( n = 98). In bivariate analyses male sex, diabetes mellitus and being former cigarette smoker were associated with IPF. After adjusting by these variables, multivariate analysis revealed that type 2 diabetes mellitus [11.3% in IPF patients vs 2.9% in controls, OR = 4.3 (95% CI: 1.9–9.8), p < 0.0001] was an independent risk factor associated to IPF. Our results provide additional evidence of a putative relationship between DM2 and idiopathic pulmonary fibrosis. Experimental research is necessary for thorough assessment of the pathogenic mechanisms involved in this association.</description><subject>Asthma</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Squamous Cell - complications</subject><subject>Case-Control Studies</subject><subject>Confidence intervals</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetes. Impaired glucose tolerance</subject><subject>Disease</subject><subject>Endocrine pancreas. Apud cells (diseases)</subject><subject>Endocrinopathies</subject><subject>Etiopathogenesis. Screening. Investigations. Target tissue resistance</subject><subject>Female</subject><subject>Gender</subject><subject>Humans</subject><subject>Idiopathic Pulmonary Fibrosis - etiology</subject><subject>Infections</subject><subject>Lung diseases</subject><subject>Lung Neoplasms - complications</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mexico</subject><subject>Middle Aged</subject><subject>Pneumology</subject><subject>Prognosis</subject><subject>Pulmonary fibrosis</subject><subject>Pulmonary/Respiratory</subject><subject>Questionnaires</subject><subject>Respiratory system : syndromes and miscellaneous diseases</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Smoking - adverse effects</subject><subject>Smoking cigarette</subject><subject>Studies</subject><subject>Tobacco smoke</subject><subject>Tobacco, tobacco smoking</subject><subject>Toxicology</subject><issn>0954-6111</issn><issn>1532-3064</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kt2L1DAUxYMo7uzqP-CDBER8ar356DQBEZbFVWFF8ONNCGl6i5ntJDVpxfnvTZlhhX3wKQ_53cM5515CnjGoGbDt612d9tjXHEDXoGpg4gHZsEbwSsBWPiQb0I2stoyxM3Ke8w4KKCU8JmdMt4o3Dd-QH198vqWDdXNMmQ4xUd_7ONn5p3d0WsZ9DDYd6OC7FLPP1Adq6Sf8450NdIqFsLOPoaaX1NmMlYthTnGkeV76wxPyaLBjxqen94J8v3737epDdfP5_cery5vKNYzPlZbFs2S9Lala4bBjSvZOMiFlJ5RTDSgEBq7lCqTsW85VqyUgWg0DdltxQV4ddacUfy2YZ7P32eE42oBxyaYVkrdKqaaQL-6Ru7ikUMwZBqK40UW6UPxIuRI6JxzMlPy-9FAgs1Zvdmat3qzVG1CmVF-Gnp-kl279uxs5dV2AlyfAZmfHIdngfL7jOBe6JF6F3hw5LJX99phMdh6Dw94ndLPpo_-_j7f3xt3oQ9nXeIsHzP_ymswNmK_rkaw3AhqAq2LgL-T7tOg</recordid><startdate>20100201</startdate><enddate>20100201</enddate><creator>García-Sancho Figueroa, Ma. 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Cecilia</au><au>Carrillo, Guillermo</au><au>Pérez-Padilla, Rogelio</au><au>Fernández-Plata, Ma. Rosario</au><au>Buendía-Roldán, Ivette</au><au>Vargas, Mario H</au><au>Selman, Moisés</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk factors for idiopathic pulmonary fibrosis in a Mexican population. A case-control study</atitle><jtitle>Respiratory medicine</jtitle><addtitle>Respir Med</addtitle><date>2010-02-01</date><risdate>2010</risdate><volume>104</volume><issue>2</issue><spage>305</spage><epage>309</epage><pages>305-309</pages><issn>0954-6111</issn><eissn>1532-3064</eissn><abstract>Summary The etiology of idiopathic pulmonary fibrosis (IPF) remains poorly understood, but some studies have suggested that cigarette smoking or other occupational or environmental exposures, diabetes mellitus, or gastroesophageal reflux may play a role. In this study we evaluated the clinical records of a group of 97 consecutive patients with IPF, and 560 patients suffering 5 different respiratory disorders that were examined as controls: asthma ( n = 111), chronic obstructive pulmonary disease ( n = 132), squamous cell lung carcinoma ( n = 118), lung adenocarcinoma ( n = 101) and patients with otorhinolaryngology problems but without lung disease ( n = 98). In bivariate analyses male sex, diabetes mellitus and being former cigarette smoker were associated with IPF. After adjusting by these variables, multivariate analysis revealed that type 2 diabetes mellitus [11.3% in IPF patients vs 2.9% in controls, OR = 4.3 (95% CI: 1.9–9.8), p < 0.0001] was an independent risk factor associated to IPF. Our results provide additional evidence of a putative relationship between DM2 and idiopathic pulmonary fibrosis. Experimental research is necessary for thorough assessment of the pathogenic mechanisms involved in this association.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>19782552</pmid><doi>10.1016/j.rmed.2009.08.013</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Asthma Biological and medical sciences Carcinoma, Squamous Cell - complications Case-Control Studies Confidence intervals Diabetes mellitus Diabetes Mellitus, Type 2 - complications Diabetes. Impaired glucose tolerance Disease Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Female Gender Humans Idiopathic Pulmonary Fibrosis - etiology Infections Lung diseases Lung Neoplasms - complications Male Medical sciences Mexico Middle Aged Pneumology Prognosis Pulmonary fibrosis Pulmonary/Respiratory Questionnaires Respiratory system : syndromes and miscellaneous diseases Retrospective Studies Risk Factors Smoking - adverse effects Smoking cigarette Studies Tobacco smoke Tobacco, tobacco smoking Toxicology |
| title | Risk factors for idiopathic pulmonary fibrosis in a Mexican population. A case-control study |
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