A novel E1B-55kD-deleted oncolytic adenovirus carrying mutant KRAS-regulated hdm2 transgene exerts specific antitumor efficacy on colorectal cancer cells

E1B-55kD-deleted adenoviruses have been used as conditionally replicative adenoviruses (CRAds) for therapeutic purposes in tumors with loss-of-function p53 mutation. To target cancer cells that harbor activating mutant KRAS (KRAS(aMut)) but spare p53(wild) normal cells, we constructed and examined b...

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Veröffentlicht in:	Molecular cancer therapeutics 2010-02, Vol.9 (2), p.450-460
Hauptverfasser:	Liu, Chin-Cheng, Liu, Jin-Hwang, Wu, Suh-Chin, Yen, Chueh-Chuan, Chen, Wei-Shone, Tsai, Ying-Chieh
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenovirus E1B Proteins - metabolism Animals Antineoplastic Agents - pharmacology Cell Line, Tumor Colorectal Neoplasms - genetics Fibroblasts - cytology Fibroblasts - metabolism Genes, p53 Genes, ras Humans Mice Mice, Nude Neoplasm Transplantation Oncolytic Viruses - genetics Proto-Oncogene Proteins c-mdm2 - genetics Transgenes
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