HPV-induced oropharyngeal cancer, immune response and response to therapy

Abstract Approximately 25% of head and neck squamous cell carcinoma (HNSCC) worldwide are associated with high-risk human papillomaviruses (HPV). HPV-positive HNSCCs have a more favorable outcome and greater response to therapy. While chronic HPV infection allows for the evolution of immune evasion...

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Veröffentlicht in:	Cancer letters 2010-02, Vol.288 (2), p.149-155
Hauptverfasser:	Vu, Ha Linh, Sikora, Andrew G, Fu, Shibo, Kao, Johnny
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - therapeutic use Carcinoma, Squamous Cell - immunology Carcinoma, Squamous Cell - radiotherapy Carcinoma, Squamous Cell - virology Cervical cancer Chronic infection Evolution Head and neck cancer Head and neck squamous cell carcinoma Hematology, Oncology and Palliative Medicine HPV Human papillomavirus Humans Immune response Immune surveillance Immune system Immune Tolerance Immunity, Innate oropharyngeal cancer Oropharyngeal Neoplasms - immunology Oropharyngeal Neoplasms - radiotherapy Oropharyngeal Neoplasms - virology Papillomaviridae - immunology Papillomaviridae - pathogenicity Papillomavirus Infections - complications Papillomavirus Infections - immunology Papillomavirus Infections - virology Prognosis Radiation Radiation therapy Radiation Tolerance Radiotherapy Risk groups squamous cell carcinoma Treatment Outcome Tumors Vaccines
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