Melatonin sensitizes human malignant glioma cells against TRAIL-induced cell death

Abstract Despite the common expression of death receptors, many types of cancer including gliomas are resistant to the death receptor ligand (TRAIL). Melatonin antitumoral actions have been extensively described, including oncostatic properties on several tumor types and improvement of chemotherapeu...

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Veröffentlicht in:	Cancer letters 2010-01, Vol.287 (2), p.216-223
Hauptverfasser:	Martín, Vanesa, García-Santos, Guillermo, Rodriguez-Blanco, Jezabel, Casado-Zapico, Sara, Sanchez-Sanchez, Ana, Antolín, Isaac, Medina, Maria, Rodriguez, Carmen
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Combined Chemotherapy Protocols - pharmacology Apoptosis Apoptosis - drug effects Cancer Cancer therapies Cell death Cell growth Cell Line, Tumor Cell Survival - drug effects Death receptors Glioma Glioma - metabolism Glioma - pathology Hematology, Oncology and Palliative Medicine Humans Inhibitor of Apoptosis Proteins Melatonin Melatonin - pharmacology Microtubule-Associated Proteins - metabolism Phosphorylation Protein Kinase C - metabolism Proto-Oncogene Proteins c-akt - metabolism Proto-Oncogene Proteins c-bcl-2 - metabolism Receptors, TNF-Related Apoptosis-Inducing Ligand - metabolism Signal Transduction - drug effects TNF-Related Apoptosis-Inducing Ligand - pharmacology TRAIL Tumors
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