Angiotensin II subtype 2 receptor blockade and deficiency attenuate the development of atherosclerosis in an apolipoprotein E-deficient mouse model of diabetes

Aims/hypothesis Most of the known actions of angiotensin II have been considered primarily to be the result of angiotensin II subtype 1 receptor activation. However, recent data suggest that the angiotensin II subtype 2 receptor (AT₂R) may modulate key processes linked to atherosclerosis. The aim of...

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Veröffentlicht in:	Diabetologia 2010-03, Vol.53 (3), p.584-592
Hauptverfasser:	Koïtka, A, Cao, Z, Koh, P, Watson, A. M. D, Sourris, K. C, Loufrani, L, Soro-Paavonen, A, Walther, T, Woollard, K. J, Jandeleit-Dahm, K. A. M, Cooper, M. E, Allen, T. J
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin Receptor Antagonists Animals Aorta - metabolism Aorta - pathology Apolipoproteins E - genetics Atherosclerosis (general aspects, experimental research) Atherosclerosis - genetics Atherosclerosis - prevention & control Biological and medical sciences Blood and lymphatic vessels Body Weight Cardiology. Vascular system Cell Adhesion Diabetes Mellitus, Experimental - metabolism Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinopathies Enzyme Inhibitors - pharmacology Etiopathogenesis. Screening. Investigations. Target tissue resistance Human Physiology Imidazoles - pharmacology Internal Medicine Male Medical sciences Medicine Medicine & Public Health Metabolic Diseases Mice Mice, Inbred C57BL Mice, Knockout Pyridines - pharmacology Receptors, Angiotensin - deficiency Receptors, CCR2 - metabolism
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