Antifatigue activity of phenylethanoid-rich extract from Cistanche deserticola
A phenylethanoid-rich extract (ECD) of Cistanche deserticola Y.C. Ma, a holoparasitic plant and a valuable traditional Chinese medicine, was evaluated for antifatigue activity in ICR mice. ECD (0.25, 0.50, 1.00 g/kg) was administered orally to mice for 3 weeks. The swimming time to exhaustion was lo...
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| Veröffentlicht in: | Phytotherapy research 2010-02, Vol.24 (2), p.313-315 |
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| creator | Cai, Run-Lan Yang, Mei-Hua Shi, Yue Chen, Jun Li, Yong-Chao Qi, Yun |
| description | A phenylethanoid-rich extract (ECD) of Cistanche deserticola Y.C. Ma, a holoparasitic plant and a valuable traditional Chinese medicine, was evaluated for antifatigue activity in ICR mice. ECD (0.25, 0.50, 1.00 g/kg) was administered orally to mice for 3 weeks. The swimming time to exhaustion was longer in the treatment groups (0.50, 1.00 g/kg) than in the control group (p < 0.01). The serum creatine kinase, lactate dehydrogenase and lactic acid levels were decreased significantly in the treatment groups compared with the control group, while the contents of hemoglobin and glucose were increased significantly. In conclusion, ECD appeared to enhance the swimming capacity of mice by decreasing muscle damage, delaying the accumulation of lactic acid and by improving the energy storage. These results provide scientific evidence for the traditional Chinese medical practice of C. deserticola. Copyright © 2009 John Wiley & Sons, Ltd. |
| doi_str_mv | 10.1002/ptr.2927 |
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Ma, a holoparasitic plant and a valuable traditional Chinese medicine, was evaluated for antifatigue activity in ICR mice. ECD (0.25, 0.50, 1.00 g/kg) was administered orally to mice for 3 weeks. The swimming time to exhaustion was longer in the treatment groups (0.50, 1.00 g/kg) than in the control group (p < 0.01). The serum creatine kinase, lactate dehydrogenase and lactic acid levels were decreased significantly in the treatment groups compared with the control group, while the contents of hemoglobin and glucose were increased significantly. In conclusion, ECD appeared to enhance the swimming capacity of mice by decreasing muscle damage, delaying the accumulation of lactic acid and by improving the energy storage. These results provide scientific evidence for the traditional Chinese medical practice of C. deserticola. Copyright © 2009 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0951-418X</identifier><identifier>EISSN: 1099-1573</identifier><identifier>DOI: 10.1002/ptr.2927</identifier><identifier>PMID: 19610039</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Animals ; antifatigue activity ; biochemical parameters ; Biological and medical sciences ; Blood Glucose ; Cistanche - chemistry ; Cistanche deserticola ; Creatine Kinase - blood ; Drugs, Chinese Herbal - pharmacology ; Fatigue - drug therapy ; General pharmacology ; Glycogen - analysis ; Hemoglobins - analysis ; L-Lactate Dehydrogenase - blood ; Lactic Acid - blood ; Liver - metabolism ; Male ; Medical sciences ; Mice ; Mice, Inbred ICR ; Muscle, Skeletal - metabolism ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; phenylethanoid ; Physical Endurance - drug effects ; Plant Extracts - pharmacology ; Swimming</subject><ispartof>Phytotherapy research, 2010-02, Vol.24 (2), p.313-315</ispartof><rights>Copyright © 2009 John Wiley & Sons, Ltd.</rights><rights>2015 INIST-CNRS</rights><rights>(c) 2009 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4127-9e2f15afb68d9a1b393559e7c80082129770fe2ce29d1a52fb846d2d6fc927cd3</citedby><cites>FETCH-LOGICAL-c4127-9e2f15afb68d9a1b393559e7c80082129770fe2ce29d1a52fb846d2d6fc927cd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fptr.2927$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fptr.2927$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22318788$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19610039$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cai, Run-Lan</creatorcontrib><creatorcontrib>Yang, Mei-Hua</creatorcontrib><creatorcontrib>Shi, Yue</creatorcontrib><creatorcontrib>Chen, Jun</creatorcontrib><creatorcontrib>Li, Yong-Chao</creatorcontrib><creatorcontrib>Qi, Yun</creatorcontrib><title>Antifatigue activity of phenylethanoid-rich extract from Cistanche deserticola</title><title>Phytotherapy research</title><addtitle>Phytother. Res</addtitle><description>A phenylethanoid-rich extract (ECD) of Cistanche deserticola Y.C. Ma, a holoparasitic plant and a valuable traditional Chinese medicine, was evaluated for antifatigue activity in ICR mice. ECD (0.25, 0.50, 1.00 g/kg) was administered orally to mice for 3 weeks. The swimming time to exhaustion was longer in the treatment groups (0.50, 1.00 g/kg) than in the control group (p < 0.01). The serum creatine kinase, lactate dehydrogenase and lactic acid levels were decreased significantly in the treatment groups compared with the control group, while the contents of hemoglobin and glucose were increased significantly. In conclusion, ECD appeared to enhance the swimming capacity of mice by decreasing muscle damage, delaying the accumulation of lactic acid and by improving the energy storage. These results provide scientific evidence for the traditional Chinese medical practice of C. deserticola. Copyright © 2009 John Wiley & Sons, Ltd.</description><subject>Animals</subject><subject>antifatigue activity</subject><subject>biochemical parameters</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose</subject><subject>Cistanche - chemistry</subject><subject>Cistanche deserticola</subject><subject>Creatine Kinase - blood</subject><subject>Drugs, Chinese Herbal - pharmacology</subject><subject>Fatigue - drug therapy</subject><subject>General pharmacology</subject><subject>Glycogen - analysis</subject><subject>Hemoglobins - analysis</subject><subject>L-Lactate Dehydrogenase - blood</subject><subject>Lactic Acid - blood</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred ICR</subject><subject>Muscle, Skeletal - metabolism</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>phenylethanoid</subject><subject>Physical Endurance - drug effects</subject><subject>Plant Extracts - pharmacology</subject><subject>Swimming</subject><issn>0951-418X</issn><issn>1099-1573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10MtOGzEUBmCroiohReIJYDZV2Qz1ZWZsL1HUhJsogqBWbCzHc0wMk5nUdgp5exxlBKtKlrz5fI7_H6EDgk8IxvTHMvoTKin_hAYES5mTkrMdNMCyJHlBxJ9dtBfCE8ZYUlx8QbtEVukdkwN0fdpGZ3V0jyvItInun4vrrLPZcg7tuoE4123n6tw7M8_gNfpkMuu7RTZyIerWzCGrIYCPznSN_oo-W90E2O_vIbof_5yOzvKrX5Pz0elVbgpCeS6BWlJqO6tELTWZMcnKUgI3AmNBCZWcYwvUAJU10SW1M1FUNa0ra1JKU7Mh-r6du_Td3xWEqBYuGGga3UK3CoqzglYpeZHk8VYa34Xgwaqldwvt14pgtSlPpfLUprxED_uhq9kC6g_Yt5XAtx7oYHRjfcrvwrujlBHBhUgu37oX18D6vwvVzfS2X9z7VCm8vnvtn1XFGS_V7-uJGks8YfLhQl0mf7T1VndKP_r0h_s7ignDRKSTJr4BtL2ePg</recordid><startdate>201002</startdate><enddate>201002</enddate><creator>Cai, Run-Lan</creator><creator>Yang, Mei-Hua</creator><creator>Shi, Yue</creator><creator>Chen, Jun</creator><creator>Li, Yong-Chao</creator><creator>Qi, Yun</creator><general>John Wiley & Sons, Ltd</general><general>Wiley</general><scope>FBQ</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201002</creationdate><title>Antifatigue activity of phenylethanoid-rich extract from Cistanche deserticola</title><author>Cai, Run-Lan ; Yang, Mei-Hua ; Shi, Yue ; Chen, Jun ; Li, Yong-Chao ; Qi, Yun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4127-9e2f15afb68d9a1b393559e7c80082129770fe2ce29d1a52fb846d2d6fc927cd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Animals</topic><topic>antifatigue activity</topic><topic>biochemical parameters</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose</topic><topic>Cistanche - chemistry</topic><topic>Cistanche deserticola</topic><topic>Creatine Kinase - blood</topic><topic>Drugs, Chinese Herbal - pharmacology</topic><topic>Fatigue - drug therapy</topic><topic>General pharmacology</topic><topic>Glycogen - analysis</topic><topic>Hemoglobins - analysis</topic><topic>L-Lactate Dehydrogenase - blood</topic><topic>Lactic Acid - blood</topic><topic>Liver - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred ICR</topic><topic>Muscle, Skeletal - metabolism</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>phenylethanoid</topic><topic>Physical Endurance - drug effects</topic><topic>Plant Extracts - pharmacology</topic><topic>Swimming</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cai, Run-Lan</creatorcontrib><creatorcontrib>Yang, Mei-Hua</creatorcontrib><creatorcontrib>Shi, Yue</creatorcontrib><creatorcontrib>Chen, Jun</creatorcontrib><creatorcontrib>Li, Yong-Chao</creatorcontrib><creatorcontrib>Qi, Yun</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Phytotherapy research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cai, Run-Lan</au><au>Yang, Mei-Hua</au><au>Shi, Yue</au><au>Chen, Jun</au><au>Li, Yong-Chao</au><au>Qi, Yun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antifatigue activity of phenylethanoid-rich extract from Cistanche deserticola</atitle><jtitle>Phytotherapy research</jtitle><addtitle>Phytother. Res</addtitle><date>2010-02</date><risdate>2010</risdate><volume>24</volume><issue>2</issue><spage>313</spage><epage>315</epage><pages>313-315</pages><issn>0951-418X</issn><eissn>1099-1573</eissn><abstract>A phenylethanoid-rich extract (ECD) of Cistanche deserticola Y.C. Ma, a holoparasitic plant and a valuable traditional Chinese medicine, was evaluated for antifatigue activity in ICR mice. ECD (0.25, 0.50, 1.00 g/kg) was administered orally to mice for 3 weeks. The swimming time to exhaustion was longer in the treatment groups (0.50, 1.00 g/kg) than in the control group (p < 0.01). The serum creatine kinase, lactate dehydrogenase and lactic acid levels were decreased significantly in the treatment groups compared with the control group, while the contents of hemoglobin and glucose were increased significantly. In conclusion, ECD appeared to enhance the swimming capacity of mice by decreasing muscle damage, delaying the accumulation of lactic acid and by improving the energy storage. These results provide scientific evidence for the traditional Chinese medical practice of C. deserticola. Copyright © 2009 John Wiley & Sons, Ltd.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>19610039</pmid><doi>10.1002/ptr.2927</doi><tpages>3</tpages></addata></record> |
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| subjects | Animals antifatigue activity biochemical parameters Biological and medical sciences Blood Glucose Cistanche - chemistry Cistanche deserticola Creatine Kinase - blood Drugs, Chinese Herbal - pharmacology Fatigue - drug therapy General pharmacology Glycogen - analysis Hemoglobins - analysis L-Lactate Dehydrogenase - blood Lactic Acid - blood Liver - metabolism Male Medical sciences Mice Mice, Inbred ICR Muscle, Skeletal - metabolism Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments phenylethanoid Physical Endurance - drug effects Plant Extracts - pharmacology Swimming |
| title | Antifatigue activity of phenylethanoid-rich extract from Cistanche deserticola |
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