Gain of the short arm of chromosome 2 (2p) is a frequent recurring chromosome aberration in untreated chronic lymphocytic leukemia (CLL) at advanced stages
Abstract Using array-based CGH, we identified 2p gain in 22/78 (28%) untreated Binet stages B/C CLL, which was the second most frequent copy number change after 13q deletion. It never occurred as a sole abnormality and was associated with other changes (6q deletion; 1p gain). The region of 2p gain f...
Gespeichert in:
| Veröffentlicht in: | Leukemia research 2010-01, Vol.34 (1), p.63-68 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 68 |
|---|---|
| container_issue | 1 |
| container_start_page | 63 |
| container_title | Leukemia research |
| container_volume | 34 |
| creator | Chapiro, Elise Leporrier, Nathalie Radford-Weiss, Isabelle Bastard, Christian Mossafa, Hossein Leroux, Dominique Tigaud, Isabelle De Braekeleer, Marc Terré, Christine Brizard, Françoise Callet-Bauchu, Evelyne Struski, Stéphanie Veronese, Lauren Fert-Ferrer, Sandra Taviaux, Sylvie Lesty, Claude Davi, Frédéric Merle-Béral, Hélène Bernard, Olivier A Sutton, Laurent Raynaud, Sophie D Nguyen-Khac, Florence |
| description | Abstract Using array-based CGH, we identified 2p gain in 22/78 (28%) untreated Binet stages B/C CLL, which was the second most frequent copy number change after 13q deletion. It never occurred as a sole abnormality and was associated with other changes (6q deletion; 1p gain). The region of 2p gain frequently included two oncogenes, REL and MYCN . All patients with gain of REL were unmutated for IGHV ( p = 0.03). Gain of MYCN was associated with increased mRNA expression ( p = 0.005), suggesting a pathogenic role for MYCN . Gain of 2p appears to be a marker of progression and may contribute to the poor prognosis. |
| doi_str_mv | 10.1016/j.leukres.2009.03.042 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_734262199</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0145212609001660</els_id><sourcerecordid>21232227</sourcerecordid><originalsourceid>FETCH-LOGICAL-c516t-59f0bee9f262087054e513ff7579a0eb41b22f4491dd15d005d8b13ef807331c3</originalsourceid><addsrcrecordid>eNqFksGO0zAQhi0EYsvCI4B8gt1Dw9iOk_gCQhUsSJU4AGfLcSZbd5O42M5KfRZeFodWAnGAky3rm3_G_z-EPGdQMGDV630x4HwXMBYcQBUgCij5A7JiTS3WshHyIVkBK-WaM15dkCcx7gFAKqYekwumSqjKWqzIjxvjJup7mnZI486HRE0Ylwe7C3700Y9IOb3ih2vqIjW0D_h9xinRgHYOwU23f5KmxRBMcn6iWXaeUkCTsPuFTM7S4Tgedt4e03LP8-PoDL3abLfX1OTO3b2ZbMZjMrcYn5JHvRkiPjufl-Tbh_dfNx_X2883nzbvtmsrWZXWUvXQIqqeVxyaGmSJkom-r2WtDGBbspbzviwV6zomu2xC17RMYN9ALQSz4pK8Oukegs9_i0mPLlocBjOhn6OuRZmlmVKZfPlPMnstOOd1BuUJtMHHGLDXh-BGE46agV7y03t9zk8v-WkQOueX616cG8ztiN3vqnNgGXh7AjAbcu8w6GgdLqa5HEjSnXf_bfHmLwU7uJyNGe7wiHHv5zBltzXTkWvQX5YlWnYIFGTRCsRPXcLEXA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>21232227</pqid></control><display><type>article</type><title>Gain of the short arm of chromosome 2 (2p) is a frequent recurring chromosome aberration in untreated chronic lymphocytic leukemia (CLL) at advanced stages</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Chapiro, Elise ; Leporrier, Nathalie ; Radford-Weiss, Isabelle ; Bastard, Christian ; Mossafa, Hossein ; Leroux, Dominique ; Tigaud, Isabelle ; De Braekeleer, Marc ; Terré, Christine ; Brizard, Françoise ; Callet-Bauchu, Evelyne ; Struski, Stéphanie ; Veronese, Lauren ; Fert-Ferrer, Sandra ; Taviaux, Sylvie ; Lesty, Claude ; Davi, Frédéric ; Merle-Béral, Hélène ; Bernard, Olivier A ; Sutton, Laurent ; Raynaud, Sophie D ; Nguyen-Khac, Florence</creator><creatorcontrib>Chapiro, Elise ; Leporrier, Nathalie ; Radford-Weiss, Isabelle ; Bastard, Christian ; Mossafa, Hossein ; Leroux, Dominique ; Tigaud, Isabelle ; De Braekeleer, Marc ; Terré, Christine ; Brizard, Françoise ; Callet-Bauchu, Evelyne ; Struski, Stéphanie ; Veronese, Lauren ; Fert-Ferrer, Sandra ; Taviaux, Sylvie ; Lesty, Claude ; Davi, Frédéric ; Merle-Béral, Hélène ; Bernard, Olivier A ; Sutton, Laurent ; Raynaud, Sophie D ; Nguyen-Khac, Florence</creatorcontrib><description>Abstract Using array-based CGH, we identified 2p gain in 22/78 (28%) untreated Binet stages B/C CLL, which was the second most frequent copy number change after 13q deletion. It never occurred as a sole abnormality and was associated with other changes (6q deletion; 1p gain). The region of 2p gain frequently included two oncogenes, REL and MYCN . All patients with gain of REL were unmutated for IGHV ( p = 0.03). Gain of MYCN was associated with increased mRNA expression ( p = 0.005), suggesting a pathogenic role for MYCN . Gain of 2p appears to be a marker of progression and may contribute to the poor prognosis.</description><identifier>ISSN: 0145-2126</identifier><identifier>EISSN: 1873-5835</identifier><identifier>DOI: 10.1016/j.leukres.2009.03.042</identifier><identifier>PMID: 19406473</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>2p gain ; Chromosome Aberrations ; Chromosomes, Human, Pair 2 ; CLL ; Gene Dosage ; Hematology, Oncology and Palliative Medicine ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell - genetics ; MYCN ; REL</subject><ispartof>Leukemia research, 2010-01, Vol.34 (1), p.63-68</ispartof><rights>Elsevier Ltd</rights><rights>2009 Elsevier Ltd</rights><rights>2009 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c516t-59f0bee9f262087054e513ff7579a0eb41b22f4491dd15d005d8b13ef807331c3</citedby><cites>FETCH-LOGICAL-c516t-59f0bee9f262087054e513ff7579a0eb41b22f4491dd15d005d8b13ef807331c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0145212609001660$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19406473$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chapiro, Elise</creatorcontrib><creatorcontrib>Leporrier, Nathalie</creatorcontrib><creatorcontrib>Radford-Weiss, Isabelle</creatorcontrib><creatorcontrib>Bastard, Christian</creatorcontrib><creatorcontrib>Mossafa, Hossein</creatorcontrib><creatorcontrib>Leroux, Dominique</creatorcontrib><creatorcontrib>Tigaud, Isabelle</creatorcontrib><creatorcontrib>De Braekeleer, Marc</creatorcontrib><creatorcontrib>Terré, Christine</creatorcontrib><creatorcontrib>Brizard, Françoise</creatorcontrib><creatorcontrib>Callet-Bauchu, Evelyne</creatorcontrib><creatorcontrib>Struski, Stéphanie</creatorcontrib><creatorcontrib>Veronese, Lauren</creatorcontrib><creatorcontrib>Fert-Ferrer, Sandra</creatorcontrib><creatorcontrib>Taviaux, Sylvie</creatorcontrib><creatorcontrib>Lesty, Claude</creatorcontrib><creatorcontrib>Davi, Frédéric</creatorcontrib><creatorcontrib>Merle-Béral, Hélène</creatorcontrib><creatorcontrib>Bernard, Olivier A</creatorcontrib><creatorcontrib>Sutton, Laurent</creatorcontrib><creatorcontrib>Raynaud, Sophie D</creatorcontrib><creatorcontrib>Nguyen-Khac, Florence</creatorcontrib><title>Gain of the short arm of chromosome 2 (2p) is a frequent recurring chromosome aberration in untreated chronic lymphocytic leukemia (CLL) at advanced stages</title><title>Leukemia research</title><addtitle>Leuk Res</addtitle><description>Abstract Using array-based CGH, we identified 2p gain in 22/78 (28%) untreated Binet stages B/C CLL, which was the second most frequent copy number change after 13q deletion. It never occurred as a sole abnormality and was associated with other changes (6q deletion; 1p gain). The region of 2p gain frequently included two oncogenes, REL and MYCN . All patients with gain of REL were unmutated for IGHV ( p = 0.03). Gain of MYCN was associated with increased mRNA expression ( p = 0.005), suggesting a pathogenic role for MYCN . Gain of 2p appears to be a marker of progression and may contribute to the poor prognosis.</description><subject>2p gain</subject><subject>Chromosome Aberrations</subject><subject>Chromosomes, Human, Pair 2</subject><subject>CLL</subject><subject>Gene Dosage</subject><subject>Hematology, Oncology and Palliative Medicine</subject><subject>Humans</subject><subject>Leukemia, Lymphocytic, Chronic, B-Cell - genetics</subject><subject>MYCN</subject><subject>REL</subject><issn>0145-2126</issn><issn>1873-5835</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFksGO0zAQhi0EYsvCI4B8gt1Dw9iOk_gCQhUsSJU4AGfLcSZbd5O42M5KfRZeFodWAnGAky3rm3_G_z-EPGdQMGDV630x4HwXMBYcQBUgCij5A7JiTS3WshHyIVkBK-WaM15dkCcx7gFAKqYekwumSqjKWqzIjxvjJup7mnZI486HRE0Ylwe7C3700Y9IOb3ih2vqIjW0D_h9xinRgHYOwU23f5KmxRBMcn6iWXaeUkCTsPuFTM7S4Tgedt4e03LP8-PoDL3abLfX1OTO3b2ZbMZjMrcYn5JHvRkiPjufl-Tbh_dfNx_X2883nzbvtmsrWZXWUvXQIqqeVxyaGmSJkom-r2WtDGBbspbzviwV6zomu2xC17RMYN9ALQSz4pK8Oukegs9_i0mPLlocBjOhn6OuRZmlmVKZfPlPMnstOOd1BuUJtMHHGLDXh-BGE46agV7y03t9zk8v-WkQOueX616cG8ztiN3vqnNgGXh7AjAbcu8w6GgdLqa5HEjSnXf_bfHmLwU7uJyNGe7wiHHv5zBltzXTkWvQX5YlWnYIFGTRCsRPXcLEXA</recordid><startdate>20100101</startdate><enddate>20100101</enddate><creator>Chapiro, Elise</creator><creator>Leporrier, Nathalie</creator><creator>Radford-Weiss, Isabelle</creator><creator>Bastard, Christian</creator><creator>Mossafa, Hossein</creator><creator>Leroux, Dominique</creator><creator>Tigaud, Isabelle</creator><creator>De Braekeleer, Marc</creator><creator>Terré, Christine</creator><creator>Brizard, Françoise</creator><creator>Callet-Bauchu, Evelyne</creator><creator>Struski, Stéphanie</creator><creator>Veronese, Lauren</creator><creator>Fert-Ferrer, Sandra</creator><creator>Taviaux, Sylvie</creator><creator>Lesty, Claude</creator><creator>Davi, Frédéric</creator><creator>Merle-Béral, Hélène</creator><creator>Bernard, Olivier A</creator><creator>Sutton, Laurent</creator><creator>Raynaud, Sophie D</creator><creator>Nguyen-Khac, Florence</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20100101</creationdate><title>Gain of the short arm of chromosome 2 (2p) is a frequent recurring chromosome aberration in untreated chronic lymphocytic leukemia (CLL) at advanced stages</title><author>Chapiro, Elise ; Leporrier, Nathalie ; Radford-Weiss, Isabelle ; Bastard, Christian ; Mossafa, Hossein ; Leroux, Dominique ; Tigaud, Isabelle ; De Braekeleer, Marc ; Terré, Christine ; Brizard, Françoise ; Callet-Bauchu, Evelyne ; Struski, Stéphanie ; Veronese, Lauren ; Fert-Ferrer, Sandra ; Taviaux, Sylvie ; Lesty, Claude ; Davi, Frédéric ; Merle-Béral, Hélène ; Bernard, Olivier A ; Sutton, Laurent ; Raynaud, Sophie D ; Nguyen-Khac, Florence</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c516t-59f0bee9f262087054e513ff7579a0eb41b22f4491dd15d005d8b13ef807331c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>2p gain</topic><topic>Chromosome Aberrations</topic><topic>Chromosomes, Human, Pair 2</topic><topic>CLL</topic><topic>Gene Dosage</topic><topic>Hematology, Oncology and Palliative Medicine</topic><topic>Humans</topic><topic>Leukemia, Lymphocytic, Chronic, B-Cell - genetics</topic><topic>MYCN</topic><topic>REL</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chapiro, Elise</creatorcontrib><creatorcontrib>Leporrier, Nathalie</creatorcontrib><creatorcontrib>Radford-Weiss, Isabelle</creatorcontrib><creatorcontrib>Bastard, Christian</creatorcontrib><creatorcontrib>Mossafa, Hossein</creatorcontrib><creatorcontrib>Leroux, Dominique</creatorcontrib><creatorcontrib>Tigaud, Isabelle</creatorcontrib><creatorcontrib>De Braekeleer, Marc</creatorcontrib><creatorcontrib>Terré, Christine</creatorcontrib><creatorcontrib>Brizard, Françoise</creatorcontrib><creatorcontrib>Callet-Bauchu, Evelyne</creatorcontrib><creatorcontrib>Struski, Stéphanie</creatorcontrib><creatorcontrib>Veronese, Lauren</creatorcontrib><creatorcontrib>Fert-Ferrer, Sandra</creatorcontrib><creatorcontrib>Taviaux, Sylvie</creatorcontrib><creatorcontrib>Lesty, Claude</creatorcontrib><creatorcontrib>Davi, Frédéric</creatorcontrib><creatorcontrib>Merle-Béral, Hélène</creatorcontrib><creatorcontrib>Bernard, Olivier A</creatorcontrib><creatorcontrib>Sutton, Laurent</creatorcontrib><creatorcontrib>Raynaud, Sophie D</creatorcontrib><creatorcontrib>Nguyen-Khac, Florence</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Leukemia research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chapiro, Elise</au><au>Leporrier, Nathalie</au><au>Radford-Weiss, Isabelle</au><au>Bastard, Christian</au><au>Mossafa, Hossein</au><au>Leroux, Dominique</au><au>Tigaud, Isabelle</au><au>De Braekeleer, Marc</au><au>Terré, Christine</au><au>Brizard, Françoise</au><au>Callet-Bauchu, Evelyne</au><au>Struski, Stéphanie</au><au>Veronese, Lauren</au><au>Fert-Ferrer, Sandra</au><au>Taviaux, Sylvie</au><au>Lesty, Claude</au><au>Davi, Frédéric</au><au>Merle-Béral, Hélène</au><au>Bernard, Olivier A</au><au>Sutton, Laurent</au><au>Raynaud, Sophie D</au><au>Nguyen-Khac, Florence</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gain of the short arm of chromosome 2 (2p) is a frequent recurring chromosome aberration in untreated chronic lymphocytic leukemia (CLL) at advanced stages</atitle><jtitle>Leukemia research</jtitle><addtitle>Leuk Res</addtitle><date>2010-01-01</date><risdate>2010</risdate><volume>34</volume><issue>1</issue><spage>63</spage><epage>68</epage><pages>63-68</pages><issn>0145-2126</issn><eissn>1873-5835</eissn><abstract>Abstract Using array-based CGH, we identified 2p gain in 22/78 (28%) untreated Binet stages B/C CLL, which was the second most frequent copy number change after 13q deletion. It never occurred as a sole abnormality and was associated with other changes (6q deletion; 1p gain). The region of 2p gain frequently included two oncogenes, REL and MYCN . All patients with gain of REL were unmutated for IGHV ( p = 0.03). Gain of MYCN was associated with increased mRNA expression ( p = 0.005), suggesting a pathogenic role for MYCN . Gain of 2p appears to be a marker of progression and may contribute to the poor prognosis.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>19406473</pmid><doi>10.1016/j.leukres.2009.03.042</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0145-2126 |
| ispartof | Leukemia research, 2010-01, Vol.34 (1), p.63-68 |
| issn | 0145-2126 1873-5835 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_734262199 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | 2p gain Chromosome Aberrations Chromosomes, Human, Pair 2 CLL Gene Dosage Hematology, Oncology and Palliative Medicine Humans Leukemia, Lymphocytic, Chronic, B-Cell - genetics MYCN REL |
| title | Gain of the short arm of chromosome 2 (2p) is a frequent recurring chromosome aberration in untreated chronic lymphocytic leukemia (CLL) at advanced stages |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T19%3A41%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Gain%20of%20the%20short%20arm%20of%20chromosome%202%20(2p)%20is%20a%20frequent%20recurring%20chromosome%20aberration%20in%20untreated%20chronic%20lymphocytic%20leukemia%20(CLL)%20at%20advanced%20stages&rft.jtitle=Leukemia%20research&rft.au=Chapiro,%20Elise&rft.date=2010-01-01&rft.volume=34&rft.issue=1&rft.spage=63&rft.epage=68&rft.pages=63-68&rft.issn=0145-2126&rft.eissn=1873-5835&rft_id=info:doi/10.1016/j.leukres.2009.03.042&rft_dat=%3Cproquest_cross%3E21232227%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=21232227&rft_id=info:pmid/19406473&rft_els_id=1_s2_0_S0145212609001660&rfr_iscdi=true |