Risk of Death Related to Psychotropic Drug Use in Older People During the European 2003 Heatwave: A Population-Based Case–Control Study
Objective The authors investigated the association between death of older people and use of psychotropic drugs before and during the Western European August 2003 heatwave. Method A retrospective population-based case–control study was conducted using the French social security insurance national dat...
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| Veröffentlicht in: | The American journal of geriatric psychiatry 2009-12, Vol.17 (12), p.1059-1067 |
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| creator | Nordon, Clementine, M.D., M.Sc Martin-Latry, Karin, Ph.D de Roquefeuil, Laurence, M.Sc Latry, Philippe, M.D., M.Sc Bégaud, Bernard, M.D., Ph.D Falissard, Bruno, M.D., Ph.D Rouillon, Frederic, M.D., Ph.D Verdoux, Helene, M.D., Ph.D |
| description | Objective The authors investigated the association between death of older people and use of psychotropic drugs before and during the Western European August 2003 heatwave. Method A retrospective population-based case–control study was conducted using the French social security insurance national database. Exposure to psychotropic drugs in cases aged 70–100 years who died before (N = 2,093) and during (N = 9,531) the August 2003 heatwave was compared with those of survivors matched for age, gender, and presence of chronic illness, by using conditional logistic regressions. Results The association between death and psychotropic drug use was modified by level of external temperature (Wald χ2 = 13.1, degree of freedom = 1, p |
| doi_str_mv | 10.1097/JGP.0b013e3181b7ef6e |
| format | Article |
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Method A retrospective population-based case–control study was conducted using the French social security insurance national database. Exposure to psychotropic drugs in cases aged 70–100 years who died before (N = 2,093) and during (N = 9,531) the August 2003 heatwave was compared with those of survivors matched for age, gender, and presence of chronic illness, by using conditional logistic regressions. Results The association between death and psychotropic drug use was modified by level of external temperature (Wald χ2 = 13.1, degree of freedom = 1, p <0.001). Use of any psychotropic drug was associated with a 30% increased risk of death during the heatwave, with a significant dose-response relationship between the number of psychotropic drugs and the risk of death (adjusted odds ratio [aOR] for linear trend 1.25, 95% confidence interval [95% CI]: 1.21–1.29). During the heatwave, therapeutic classes independently associated with an increased risk of death were antidepressants (aOR 1.71, 95% CI: 1.57–1.86) and antipsychotics (aOR 2.09, 95% CI: 1.89–2.35), whereas exposure to anxiolytics/hypnotics use (aOR 0.85, 0.79–0.91) was associated with a decreased risk. Findings remained unchanged after adjustment on cardiotropic, antidementia, or anti-parkinsonian drug use. Conclusion Our findings suggest that a causal relationship may exist between psychotropic drug use during a heatwave and increased risk of death in older people. The risk/benefit ratio of antidepressant and antipsychotic drugs should be carefully assessed in older people during a heatwave.</description><identifier>ISSN: 1064-7481</identifier><identifier>EISSN: 1545-7214</identifier><identifier>DOI: 10.1097/JGP.0b013e3181b7ef6e</identifier><identifier>PMID: 20104062</identifier><language>eng</language><publisher>England: Elsevier Inc</publisher><subject>Aged ; Aged, 80 and over ; Antidepressive Agents - adverse effects ; Antipsychotic Agents - adverse effects ; Case-Control Studies ; Dose-Response Relationship, Drug ; Europe - epidemiology ; Female ; France - epidemiology ; Geriatric Assessment - methods ; Geriatric Assessment - statistics & numerical data ; Heat Stress Disorders - chemically induced ; Heat Stress Disorders - mortality ; Heatwave ; Hot Temperature - adverse effects ; Humans ; Internal Medicine ; Male ; mortality ; Odds Ratio ; psychotropic drug ; Psychotropic Drugs - adverse effects ; Retrospective Studies ; Risk Factors</subject><ispartof>The American journal of geriatric psychiatry, 2009-12, Vol.17 (12), p.1059-1067</ispartof><rights>American Association for Geriatric Psychiatry</rights><rights>2009 American Association for Geriatric Psychiatry</rights><rights>Copyright Lippincott Williams & Wilkins Dec 2009</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c509t-3f0951d3ffb044103989c6b304b98e75de0aee1e3db262532e30123912af792d3</citedby><cites>FETCH-LOGICAL-c509t-3f0951d3ffb044103989c6b304b98e75de0aee1e3db262532e30123912af792d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20104062$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nordon, Clementine, M.D., M.Sc</creatorcontrib><creatorcontrib>Martin-Latry, Karin, Ph.D</creatorcontrib><creatorcontrib>de Roquefeuil, Laurence, M.Sc</creatorcontrib><creatorcontrib>Latry, Philippe, M.D., M.Sc</creatorcontrib><creatorcontrib>Bégaud, Bernard, M.D., Ph.D</creatorcontrib><creatorcontrib>Falissard, Bruno, M.D., Ph.D</creatorcontrib><creatorcontrib>Rouillon, Frederic, M.D., Ph.D</creatorcontrib><creatorcontrib>Verdoux, Helene, M.D., Ph.D</creatorcontrib><title>Risk of Death Related to Psychotropic Drug Use in Older People During the European 2003 Heatwave: A Population-Based Case–Control Study</title><title>The American journal of geriatric psychiatry</title><addtitle>Am J Geriatr Psychiatry</addtitle><description>Objective The authors investigated the association between death of older people and use of psychotropic drugs before and during the Western European August 2003 heatwave. Method A retrospective population-based case–control study was conducted using the French social security insurance national database. Exposure to psychotropic drugs in cases aged 70–100 years who died before (N = 2,093) and during (N = 9,531) the August 2003 heatwave was compared with those of survivors matched for age, gender, and presence of chronic illness, by using conditional logistic regressions. Results The association between death and psychotropic drug use was modified by level of external temperature (Wald χ2 = 13.1, degree of freedom = 1, p <0.001). Use of any psychotropic drug was associated with a 30% increased risk of death during the heatwave, with a significant dose-response relationship between the number of psychotropic drugs and the risk of death (adjusted odds ratio [aOR] for linear trend 1.25, 95% confidence interval [95% CI]: 1.21–1.29). During the heatwave, therapeutic classes independently associated with an increased risk of death were antidepressants (aOR 1.71, 95% CI: 1.57–1.86) and antipsychotics (aOR 2.09, 95% CI: 1.89–2.35), whereas exposure to anxiolytics/hypnotics use (aOR 0.85, 0.79–0.91) was associated with a decreased risk. Findings remained unchanged after adjustment on cardiotropic, antidementia, or anti-parkinsonian drug use. Conclusion Our findings suggest that a causal relationship may exist between psychotropic drug use during a heatwave and increased risk of death in older people. The risk/benefit ratio of antidepressant and antipsychotic drugs should be carefully assessed in older people during a heatwave.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antidepressive Agents - adverse effects</subject><subject>Antipsychotic Agents - adverse effects</subject><subject>Case-Control Studies</subject><subject>Dose-Response Relationship, Drug</subject><subject>Europe - epidemiology</subject><subject>Female</subject><subject>France - epidemiology</subject><subject>Geriatric Assessment - methods</subject><subject>Geriatric Assessment - statistics & numerical data</subject><subject>Heat Stress Disorders - chemically induced</subject><subject>Heat Stress Disorders - mortality</subject><subject>Heatwave</subject><subject>Hot Temperature - adverse effects</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>mortality</subject><subject>Odds Ratio</subject><subject>psychotropic drug</subject><subject>Psychotropic Drugs - 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adverse effects</topic><topic>Antipsychotic Agents - adverse effects</topic><topic>Case-Control Studies</topic><topic>Dose-Response Relationship, Drug</topic><topic>Europe - epidemiology</topic><topic>Female</topic><topic>France - epidemiology</topic><topic>Geriatric Assessment - methods</topic><topic>Geriatric Assessment - statistics & numerical data</topic><topic>Heat Stress Disorders - chemically induced</topic><topic>Heat Stress Disorders - mortality</topic><topic>Heatwave</topic><topic>Hot Temperature - adverse effects</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>mortality</topic><topic>Odds Ratio</topic><topic>psychotropic drug</topic><topic>Psychotropic Drugs - adverse effects</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nordon, Clementine, M.D., M.Sc</creatorcontrib><creatorcontrib>Martin-Latry, Karin, Ph.D</creatorcontrib><creatorcontrib>de Roquefeuil, Laurence, M.Sc</creatorcontrib><creatorcontrib>Latry, Philippe, M.D., M.Sc</creatorcontrib><creatorcontrib>Bégaud, Bernard, M.D., Ph.D</creatorcontrib><creatorcontrib>Falissard, Bruno, M.D., Ph.D</creatorcontrib><creatorcontrib>Rouillon, Frederic, M.D., Ph.D</creatorcontrib><creatorcontrib>Verdoux, Helene, M.D., Ph.D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Docstoc</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Social Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Social Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of geriatric psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nordon, Clementine, M.D., M.Sc</au><au>Martin-Latry, Karin, Ph.D</au><au>de Roquefeuil, Laurence, M.Sc</au><au>Latry, Philippe, M.D., M.Sc</au><au>Bégaud, Bernard, M.D., Ph.D</au><au>Falissard, Bruno, M.D., Ph.D</au><au>Rouillon, Frederic, M.D., Ph.D</au><au>Verdoux, Helene, M.D., Ph.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk of Death Related to Psychotropic Drug Use in Older People During the European 2003 Heatwave: A Population-Based Case–Control Study</atitle><jtitle>The American journal of geriatric psychiatry</jtitle><addtitle>Am J Geriatr Psychiatry</addtitle><date>2009-12-01</date><risdate>2009</risdate><volume>17</volume><issue>12</issue><spage>1059</spage><epage>1067</epage><pages>1059-1067</pages><issn>1064-7481</issn><eissn>1545-7214</eissn><abstract>Objective The authors investigated the association between death of older people and use of psychotropic drugs before and during the Western European August 2003 heatwave. Method A retrospective population-based case–control study was conducted using the French social security insurance national database. Exposure to psychotropic drugs in cases aged 70–100 years who died before (N = 2,093) and during (N = 9,531) the August 2003 heatwave was compared with those of survivors matched for age, gender, and presence of chronic illness, by using conditional logistic regressions. Results The association between death and psychotropic drug use was modified by level of external temperature (Wald χ2 = 13.1, degree of freedom = 1, p <0.001). Use of any psychotropic drug was associated with a 30% increased risk of death during the heatwave, with a significant dose-response relationship between the number of psychotropic drugs and the risk of death (adjusted odds ratio [aOR] for linear trend 1.25, 95% confidence interval [95% CI]: 1.21–1.29). During the heatwave, therapeutic classes independently associated with an increased risk of death were antidepressants (aOR 1.71, 95% CI: 1.57–1.86) and antipsychotics (aOR 2.09, 95% CI: 1.89–2.35), whereas exposure to anxiolytics/hypnotics use (aOR 0.85, 0.79–0.91) was associated with a decreased risk. Findings remained unchanged after adjustment on cardiotropic, antidementia, or anti-parkinsonian drug use. Conclusion Our findings suggest that a causal relationship may exist between psychotropic drug use during a heatwave and increased risk of death in older people. The risk/benefit ratio of antidepressant and antipsychotic drugs should be carefully assessed in older people during a heatwave.</abstract><cop>England</cop><pub>Elsevier Inc</pub><pmid>20104062</pmid><doi>10.1097/JGP.0b013e3181b7ef6e</doi><tpages>9</tpages></addata></record> |
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| identifier | ISSN: 1064-7481 |
| ispartof | The American journal of geriatric psychiatry, 2009-12, Vol.17 (12), p.1059-1067 |
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| subjects | Aged Aged, 80 and over Antidepressive Agents - adverse effects Antipsychotic Agents - adverse effects Case-Control Studies Dose-Response Relationship, Drug Europe - epidemiology Female France - epidemiology Geriatric Assessment - methods Geriatric Assessment - statistics & numerical data Heat Stress Disorders - chemically induced Heat Stress Disorders - mortality Heatwave Hot Temperature - adverse effects Humans Internal Medicine Male mortality Odds Ratio psychotropic drug Psychotropic Drugs - adverse effects Retrospective Studies Risk Factors |
| title | Risk of Death Related to Psychotropic Drug Use in Older People During the European 2003 Heatwave: A Population-Based Case–Control Study |
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