Serum protein signature may improve detection of ductal carcinoma in situ of the breast
Ductal carcinoma in situ (DCIS) of the breast is part of a spectrum of preinvasive lesions that originate within normal breast tissue and progress to invasive breast cancer. The detection of DCIS is important for the reduction of mortality from breast cancer, but the diagnosis of preinvasive breast...
Gespeichert in:
| Veröffentlicht in: | Oncogene 2010-01, Vol.29 (4), p.550-560 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 560 |
|---|---|
| container_issue | 4 |
| container_start_page | 550 |
| container_title | Oncogene |
| container_volume | 29 |
| creator | Solassol, J Rouanet, P Lamy, P J Allal, C Favre, G Maudelonde, T Mangé, A |
| description | Ductal carcinoma
in situ
(DCIS) of the breast is part of a spectrum of preinvasive lesions that originate within normal breast tissue and progress to invasive breast cancer. The detection of DCIS is important for the reduction of mortality from breast cancer, but the diagnosis of preinvasive breast tumors is hampered by the lack of an adequate detection method. To identify the changes in protein expression during the initial stage of tumorigenesis and to identify the presence of new DCIS markers, we analysed serum from 60 patients with breast cancer and 60 normal controls using mass spectrometry. A 23-protein index was generated that correctly distinguishes the DCIS and control groups with sensitivities and specificities in excess of 80% in two independent cohorts. Two candidate peptides were purified and identified as platelet factor 4 (PF-4) and complement C3a
desArg
anaphylatoxin (C3a
desArg
) using liquid chromatography–tandem mass spectrometry (LC–MS/MS). In an independent serum set of 165 patients, PF-4 and C3a
desArg
were significantly upregulated in DCIS compared with non-cancerous controls, as validated using western blot and enzyme-linked immunosorbent assay. We conclude that our serum protein-based test, used in conjunction with image-based screening practices, could improve the sensitivity and specificity of breast cancer detection. |
| doi_str_mv | 10.1038/onc.2009.341 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_734259802</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A218528072</galeid><sourcerecordid>A218528072</sourcerecordid><originalsourceid>FETCH-LOGICAL-c587t-195522e81fb5084fcaa6f99fc0569c6e6908ac413d13313c2d5c6f9a1c3d10ee3</originalsourceid><addsrcrecordid>eNp9kc2LFDEQxRtR3HH15lmCi3qxx3x0upPjsvgFCx5UPIZMdWXM0p2sSVrY_960M7goi-QQqPq9V1W8pnnK6JZRod7EAFtOqd6Kjt1rNqwb-lZK3d1vNlRL2mou-EnzKOcrSumgKX_YnDCtpOy43jTfPmNaZnKdYkEfSPb7YMuSkMz2hvi51n8iGbEgFB8DiY6MCxQ7EbAJfIizJb9lZVl75TuSXUKby-PmgbNTxifH_7T5-u7tl4sP7eWn9x8vzi9bkGooLdNSco6KuZ2kqnNgbe-0dkBlr6HHXlNloWNiZEIwAXyUUAHLoFYoojhtXh1866Y_FszFzD4DTpMNGJdsBtFxqRXllXz5X5LXCZ1gK_j8H_AqLinUKwzn1U8poSt0doD2dkLjg4slWVgdzTlnSnJFh9VqewdV34izhxjQ-Vr_S_D6IIAUc07ozHXys003hlGzxm1q3GaN29S4K_7suOqym3G8hY_5VuDFEbAZ7OSSDeDzH45zoRVTtHLtgcu1FfaYbm--c_AvEiO_Ew</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>227348839</pqid></control><display><type>article</type><title>Serum protein signature may improve detection of ductal carcinoma in situ of the breast</title><source>MEDLINE</source><source>Nature</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Solassol, J ; Rouanet, P ; Lamy, P J ; Allal, C ; Favre, G ; Maudelonde, T ; Mangé, A</creator><creatorcontrib>Solassol, J ; Rouanet, P ; Lamy, P J ; Allal, C ; Favre, G ; Maudelonde, T ; Mangé, A</creatorcontrib><description>Ductal carcinoma
in situ
(DCIS) of the breast is part of a spectrum of preinvasive lesions that originate within normal breast tissue and progress to invasive breast cancer. The detection of DCIS is important for the reduction of mortality from breast cancer, but the diagnosis of preinvasive breast tumors is hampered by the lack of an adequate detection method. To identify the changes in protein expression during the initial stage of tumorigenesis and to identify the presence of new DCIS markers, we analysed serum from 60 patients with breast cancer and 60 normal controls using mass spectrometry. A 23-protein index was generated that correctly distinguishes the DCIS and control groups with sensitivities and specificities in excess of 80% in two independent cohorts. Two candidate peptides were purified and identified as platelet factor 4 (PF-4) and complement C3a
desArg
anaphylatoxin (C3a
desArg
) using liquid chromatography–tandem mass spectrometry (LC–MS/MS). In an independent serum set of 165 patients, PF-4 and C3a
desArg
were significantly upregulated in DCIS compared with non-cancerous controls, as validated using western blot and enzyme-linked immunosorbent assay. We conclude that our serum protein-based test, used in conjunction with image-based screening practices, could improve the sensitivity and specificity of breast cancer detection.</description><identifier>ISSN: 0950-9232</identifier><identifier>EISSN: 1476-5594</identifier><identifier>DOI: 10.1038/onc.2009.341</identifier><identifier>PMID: 19855429</identifier><identifier>CODEN: ONCNES</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>Amino Acid Sequence ; Apoptosis ; Biological and medical sciences ; Biological markers ; Biomarkers, Tumor - blood ; Biomarkers, Tumor - chemistry ; Blood tests ; Breast cancer ; Breast Neoplasms - blood ; Breast Neoplasms - chemistry ; Breast Neoplasms - diagnosis ; Carcinoma, Ductal, Breast - blood ; Carcinoma, Ductal, Breast - chemistry ; Carcinoma, Ductal, Breast - diagnosis ; Cell Biology ; Cell physiology ; Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes ; Complement C3 - analysis ; Complement C3 - chemistry ; Development and progression ; Diagnosis ; Diagnostic tests ; Enzyme-linked immunosorbent assay ; Fundamental and applied biological sciences. Psychology ; Genetics ; Gynecology. Andrology. Obstetrics ; Human Genetics ; Humans ; Internal Medicine ; Mammary gland diseases ; Medical sciences ; Medicine ; Medicine & Public Health ; Molecular and cellular biology ; Molecular Sequence Data ; Oncology ; original-article ; Platelet Factor 4 - blood ; Platelet Factor 4 - chemistry ; Protein Array Analysis ; Proteins ; Tandem Mass Spectrometry ; Tumors ; Up-Regulation</subject><ispartof>Oncogene, 2010-01, Vol.29 (4), p.550-560</ispartof><rights>Macmillan Publishers Limited 2010</rights><rights>2015 INIST-CNRS</rights><rights>COPYRIGHT 2010 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Jan 28, 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c587t-195522e81fb5084fcaa6f99fc0569c6e6908ac413d13313c2d5c6f9a1c3d10ee3</citedby><cites>FETCH-LOGICAL-c587t-195522e81fb5084fcaa6f99fc0569c6e6908ac413d13313c2d5c6f9a1c3d10ee3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22398180$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19855429$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Solassol, J</creatorcontrib><creatorcontrib>Rouanet, P</creatorcontrib><creatorcontrib>Lamy, P J</creatorcontrib><creatorcontrib>Allal, C</creatorcontrib><creatorcontrib>Favre, G</creatorcontrib><creatorcontrib>Maudelonde, T</creatorcontrib><creatorcontrib>Mangé, A</creatorcontrib><title>Serum protein signature may improve detection of ductal carcinoma in situ of the breast</title><title>Oncogene</title><addtitle>Oncogene</addtitle><addtitle>Oncogene</addtitle><description>Ductal carcinoma
in situ
(DCIS) of the breast is part of a spectrum of preinvasive lesions that originate within normal breast tissue and progress to invasive breast cancer. The detection of DCIS is important for the reduction of mortality from breast cancer, but the diagnosis of preinvasive breast tumors is hampered by the lack of an adequate detection method. To identify the changes in protein expression during the initial stage of tumorigenesis and to identify the presence of new DCIS markers, we analysed serum from 60 patients with breast cancer and 60 normal controls using mass spectrometry. A 23-protein index was generated that correctly distinguishes the DCIS and control groups with sensitivities and specificities in excess of 80% in two independent cohorts. Two candidate peptides were purified and identified as platelet factor 4 (PF-4) and complement C3a
desArg
anaphylatoxin (C3a
desArg
) using liquid chromatography–tandem mass spectrometry (LC–MS/MS). In an independent serum set of 165 patients, PF-4 and C3a
desArg
were significantly upregulated in DCIS compared with non-cancerous controls, as validated using western blot and enzyme-linked immunosorbent assay. We conclude that our serum protein-based test, used in conjunction with image-based screening practices, could improve the sensitivity and specificity of breast cancer detection.</description><subject>Amino Acid Sequence</subject><subject>Apoptosis</subject><subject>Biological and medical sciences</subject><subject>Biological markers</subject><subject>Biomarkers, Tumor - blood</subject><subject>Biomarkers, Tumor - chemistry</subject><subject>Blood tests</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - blood</subject><subject>Breast Neoplasms - chemistry</subject><subject>Breast Neoplasms - diagnosis</subject><subject>Carcinoma, Ductal, Breast - blood</subject><subject>Carcinoma, Ductal, Breast - chemistry</subject><subject>Carcinoma, Ductal, Breast - diagnosis</subject><subject>Cell Biology</subject><subject>Cell physiology</subject><subject>Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes</subject><subject>Complement C3 - analysis</subject><subject>Complement C3 - chemistry</subject><subject>Development and progression</subject><subject>Diagnosis</subject><subject>Diagnostic tests</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetics</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Mammary gland diseases</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Molecular and cellular biology</subject><subject>Molecular Sequence Data</subject><subject>Oncology</subject><subject>original-article</subject><subject>Platelet Factor 4 - blood</subject><subject>Platelet Factor 4 - chemistry</subject><subject>Protein Array Analysis</subject><subject>Proteins</subject><subject>Tandem Mass Spectrometry</subject><subject>Tumors</subject><subject>Up-Regulation</subject><issn>0950-9232</issn><issn>1476-5594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kc2LFDEQxRtR3HH15lmCi3qxx3x0upPjsvgFCx5UPIZMdWXM0p2sSVrY_960M7goi-QQqPq9V1W8pnnK6JZRod7EAFtOqd6Kjt1rNqwb-lZK3d1vNlRL2mou-EnzKOcrSumgKX_YnDCtpOy43jTfPmNaZnKdYkEfSPb7YMuSkMz2hvi51n8iGbEgFB8DiY6MCxQ7EbAJfIizJb9lZVl75TuSXUKby-PmgbNTxifH_7T5-u7tl4sP7eWn9x8vzi9bkGooLdNSco6KuZ2kqnNgbe-0dkBlr6HHXlNloWNiZEIwAXyUUAHLoFYoojhtXh1866Y_FszFzD4DTpMNGJdsBtFxqRXllXz5X5LXCZ1gK_j8H_AqLinUKwzn1U8poSt0doD2dkLjg4slWVgdzTlnSnJFh9VqewdV34izhxjQ-Vr_S_D6IIAUc07ozHXys003hlGzxm1q3GaN29S4K_7suOqym3G8hY_5VuDFEbAZ7OSSDeDzH45zoRVTtHLtgcu1FfaYbm--c_AvEiO_Ew</recordid><startdate>20100128</startdate><enddate>20100128</enddate><creator>Solassol, J</creator><creator>Rouanet, P</creator><creator>Lamy, P J</creator><creator>Allal, C</creator><creator>Favre, G</creator><creator>Maudelonde, T</creator><creator>Mangé, A</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20100128</creationdate><title>Serum protein signature may improve detection of ductal carcinoma in situ of the breast</title><author>Solassol, J ; Rouanet, P ; Lamy, P J ; Allal, C ; Favre, G ; Maudelonde, T ; Mangé, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c587t-195522e81fb5084fcaa6f99fc0569c6e6908ac413d13313c2d5c6f9a1c3d10ee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Amino Acid Sequence</topic><topic>Apoptosis</topic><topic>Biological and medical sciences</topic><topic>Biological markers</topic><topic>Biomarkers, Tumor - blood</topic><topic>Biomarkers, Tumor - chemistry</topic><topic>Blood tests</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - blood</topic><topic>Breast Neoplasms - chemistry</topic><topic>Breast Neoplasms - diagnosis</topic><topic>Carcinoma, Ductal, Breast - blood</topic><topic>Carcinoma, Ductal, Breast - chemistry</topic><topic>Carcinoma, Ductal, Breast - diagnosis</topic><topic>Cell Biology</topic><topic>Cell physiology</topic><topic>Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes</topic><topic>Complement C3 - analysis</topic><topic>Complement C3 - chemistry</topic><topic>Development and progression</topic><topic>Diagnosis</topic><topic>Diagnostic tests</topic><topic>Enzyme-linked immunosorbent assay</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genetics</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Mammary gland diseases</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Molecular and cellular biology</topic><topic>Molecular Sequence Data</topic><topic>Oncology</topic><topic>original-article</topic><topic>Platelet Factor 4 - blood</topic><topic>Platelet Factor 4 - chemistry</topic><topic>Protein Array Analysis</topic><topic>Proteins</topic><topic>Tandem Mass Spectrometry</topic><topic>Tumors</topic><topic>Up-Regulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Solassol, J</creatorcontrib><creatorcontrib>Rouanet, P</creatorcontrib><creatorcontrib>Lamy, P J</creatorcontrib><creatorcontrib>Allal, C</creatorcontrib><creatorcontrib>Favre, G</creatorcontrib><creatorcontrib>Maudelonde, T</creatorcontrib><creatorcontrib>Mangé, A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Oncogene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Solassol, J</au><au>Rouanet, P</au><au>Lamy, P J</au><au>Allal, C</au><au>Favre, G</au><au>Maudelonde, T</au><au>Mangé, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum protein signature may improve detection of ductal carcinoma in situ of the breast</atitle><jtitle>Oncogene</jtitle><stitle>Oncogene</stitle><addtitle>Oncogene</addtitle><date>2010-01-28</date><risdate>2010</risdate><volume>29</volume><issue>4</issue><spage>550</spage><epage>560</epage><pages>550-560</pages><issn>0950-9232</issn><eissn>1476-5594</eissn><coden>ONCNES</coden><abstract>Ductal carcinoma
in situ
(DCIS) of the breast is part of a spectrum of preinvasive lesions that originate within normal breast tissue and progress to invasive breast cancer. The detection of DCIS is important for the reduction of mortality from breast cancer, but the diagnosis of preinvasive breast tumors is hampered by the lack of an adequate detection method. To identify the changes in protein expression during the initial stage of tumorigenesis and to identify the presence of new DCIS markers, we analysed serum from 60 patients with breast cancer and 60 normal controls using mass spectrometry. A 23-protein index was generated that correctly distinguishes the DCIS and control groups with sensitivities and specificities in excess of 80% in two independent cohorts. Two candidate peptides were purified and identified as platelet factor 4 (PF-4) and complement C3a
desArg
anaphylatoxin (C3a
desArg
) using liquid chromatography–tandem mass spectrometry (LC–MS/MS). In an independent serum set of 165 patients, PF-4 and C3a
desArg
were significantly upregulated in DCIS compared with non-cancerous controls, as validated using western blot and enzyme-linked immunosorbent assay. We conclude that our serum protein-based test, used in conjunction with image-based screening practices, could improve the sensitivity and specificity of breast cancer detection.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>19855429</pmid><doi>10.1038/onc.2009.341</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0950-9232 |
| ispartof | Oncogene, 2010-01, Vol.29 (4), p.550-560 |
| issn | 0950-9232 1476-5594 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_734259802 |
| source | MEDLINE; Nature; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Amino Acid Sequence Apoptosis Biological and medical sciences Biological markers Biomarkers, Tumor - blood Biomarkers, Tumor - chemistry Blood tests Breast cancer Breast Neoplasms - blood Breast Neoplasms - chemistry Breast Neoplasms - diagnosis Carcinoma, Ductal, Breast - blood Carcinoma, Ductal, Breast - chemistry Carcinoma, Ductal, Breast - diagnosis Cell Biology Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Complement C3 - analysis Complement C3 - chemistry Development and progression Diagnosis Diagnostic tests Enzyme-linked immunosorbent assay Fundamental and applied biological sciences. Psychology Genetics Gynecology. Andrology. Obstetrics Human Genetics Humans Internal Medicine Mammary gland diseases Medical sciences Medicine Medicine & Public Health Molecular and cellular biology Molecular Sequence Data Oncology original-article Platelet Factor 4 - blood Platelet Factor 4 - chemistry Protein Array Analysis Proteins Tandem Mass Spectrometry Tumors Up-Regulation |
| title | Serum protein signature may improve detection of ductal carcinoma in situ of the breast |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T05%3A08%3A18IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Serum%20protein%20signature%20may%20improve%20detection%20of%20ductal%20carcinoma%20in%20situ%20of%20the%20breast&rft.jtitle=Oncogene&rft.au=Solassol,%20J&rft.date=2010-01-28&rft.volume=29&rft.issue=4&rft.spage=550&rft.epage=560&rft.pages=550-560&rft.issn=0950-9232&rft.eissn=1476-5594&rft.coden=ONCNES&rft_id=info:doi/10.1038/onc.2009.341&rft_dat=%3Cgale_proqu%3EA218528072%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=227348839&rft_id=info:pmid/19855429&rft_galeid=A218528072&rfr_iscdi=true |