Does storage time influence postthaw survival and pregnancy outcome? An analysis of 11,768 cryopreserved human embryos
Objective To evaluate the impact of cryopreservation storage duration on embryo survival, implantation competence, and pregnancy outcome. Design Retrospective study. Setting Academic tertiary-referral infertility center. Patient(s) In vitro fertilization patients and recipients of oocyte donation cy...
Gespeichert in:
| Veröffentlicht in: | Fertility and sterility 2010, Vol.93 (1), p.109-115 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 115 |
|---|---|
| container_issue | 1 |
| container_start_page | 109 |
| container_title | Fertility and sterility |
| container_volume | 93 |
| creator | Riggs, Ryan, M.D Mayer, Jacob, Ph.D Dowling-Lacey, Donna, M.S Chi, Ting-Fing, Ph.D Jones, Estella, M.S Oehninger, Sergio, M.D., Ph.D |
| description | Objective To evaluate the impact of cryopreservation storage duration on embryo survival, implantation competence, and pregnancy outcome. Design Retrospective study. Setting Academic tertiary-referral infertility center. Patient(s) In vitro fertilization patients and recipients of oocyte donation cycles who had cryopreserved embryos and underwent at least one thaw cycle from 1986 to 2007. Intervention(s) None. Main Outcome Measure(s) Postthaw survival proportion and implantation, clinical pregnancy, miscarriage, and live birth rates. Result(s) Length of storage time did not have a significant effect on postthaw survival for IVF or oocyte donation cycles, or for embryos frozen at the pronuclear or cleavage stages. There was no significant impact of the duration of storage on clinical pregnancy, miscarriage, implantation, or live birth rate, whether from IVF or oocyte donation cycles. Logistic regression analysis demonstrated that the length of storage time or developmental stage at freezing were not predictive of embryo survival or pregnancy outcome. Only oocyte age, survival proportion, and number of transferred embryos were positive predictors of pregnancy outcome. Conclusion(s) Cryostorage duration did not adversely affect postthaw survival or pregnancy outcome in IVF or oocyte donation patients. |
| doi_str_mv | 10.1016/j.fertnstert.2008.09.084 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_734259364</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0015028208041228</els_id><sourcerecordid>734259364</sourcerecordid><originalsourceid>FETCH-LOGICAL-c508t-76fb71f56dc5ef0834f6232e7ad8ea03ab9baf8b15f6a2c87837900c4e7064c73</originalsourceid><addsrcrecordid>eNqNkkuP0zAQgCMEYsvCX0C-IC60jJ34kQtoWZ7SShyAs-U4412XJC6epKj_HletWIkTF1uyv5mxv5mqYhw2HLh6vd0EzPNEc1k3AsBsoN2AaR5UKy6lWksl64fVCoDLNQgjLqonRFsAUFyLx9UFb0FozmFV7d8nJEZzyu4W2RxHZHEKw4KTR7ZLNM937jejJe_j3g3MTT3bZbyd3OQPLC2zTyO-ZVdTuXHDgSKxFBjnr7QyzOdDKjBh3mPP7pbRTQzHrpzS0-pRcAPhs_N-Wf34-OH79ef1zddPX66vbtZegpnXWoVO8yBV7yUGMHUTlKgFatcbdFC7ru1cMB2XQTnhjTa1bgF8gxpU43V9Wb085d3l9GtBmu0YyeMwuAnTQlbXjZBtrZpCmhPpcyLKGOwux9Hlg-Vgj9Lt1t5Lt0fpFlpbpJfQ5-ciSzdifx94tlyAF2fAkXdDyMVepL-cKF-qZWsK9-7EYVGyj5gt-XjsRB8z-tn2Kf7Pa978k8QPcYql7k88IG3TkkuryHJLwoL9dhyS44yAgYYLYeo_BIi79g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>734259364</pqid></control><display><type>article</type><title>Does storage time influence postthaw survival and pregnancy outcome? An analysis of 11,768 cryopreserved human embryos</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>ScienceDirect Journals (5 years ago - present)</source><source>Alma/SFX Local Collection</source><creator>Riggs, Ryan, M.D ; Mayer, Jacob, Ph.D ; Dowling-Lacey, Donna, M.S ; Chi, Ting-Fing, Ph.D ; Jones, Estella, M.S ; Oehninger, Sergio, M.D., Ph.D</creator><creatorcontrib>Riggs, Ryan, M.D ; Mayer, Jacob, Ph.D ; Dowling-Lacey, Donna, M.S ; Chi, Ting-Fing, Ph.D ; Jones, Estella, M.S ; Oehninger, Sergio, M.D., Ph.D</creatorcontrib><description>Objective To evaluate the impact of cryopreservation storage duration on embryo survival, implantation competence, and pregnancy outcome. Design Retrospective study. Setting Academic tertiary-referral infertility center. Patient(s) In vitro fertilization patients and recipients of oocyte donation cycles who had cryopreserved embryos and underwent at least one thaw cycle from 1986 to 2007. Intervention(s) None. Main Outcome Measure(s) Postthaw survival proportion and implantation, clinical pregnancy, miscarriage, and live birth rates. Result(s) Length of storage time did not have a significant effect on postthaw survival for IVF or oocyte donation cycles, or for embryos frozen at the pronuclear or cleavage stages. There was no significant impact of the duration of storage on clinical pregnancy, miscarriage, implantation, or live birth rate, whether from IVF or oocyte donation cycles. Logistic regression analysis demonstrated that the length of storage time or developmental stage at freezing were not predictive of embryo survival or pregnancy outcome. Only oocyte age, survival proportion, and number of transferred embryos were positive predictors of pregnancy outcome. Conclusion(s) Cryostorage duration did not adversely affect postthaw survival or pregnancy outcome in IVF or oocyte donation patients.</description><identifier>ISSN: 0015-0282</identifier><identifier>EISSN: 1556-5653</identifier><identifier>DOI: 10.1016/j.fertnstert.2008.09.084</identifier><identifier>PMID: 19027110</identifier><identifier>CODEN: FESTAS</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Abortion, Spontaneous ; Adult ; Biological and medical sciences ; Cryopreservation ; Embryo cryopreservation ; Embryo Implantation ; Embryo Transfer ; Embryo, Mammalian ; Female ; Fertilization in Vitro ; Gynecology. Andrology. Obstetrics ; Humans ; implantation ; Infertility - therapy ; Internal Medicine ; Live Birth ; Logistic Models ; Medical sciences ; Obstetrics and Gynecology ; Odds Ratio ; Oocyte Donation ; postthaw survival ; Pregnancy ; Pregnancy Outcome ; Pregnancy Rate ; Reproductive Techniques, Assisted - adverse effects ; Retrospective Studies ; storage time ; Time Factors ; Treatment Outcome</subject><ispartof>Fertility and sterility, 2010, Vol.93 (1), p.109-115</ispartof><rights>American Society for Reproductive Medicine</rights><rights>2010 American Society for Reproductive Medicine</rights><rights>2015 INIST-CNRS</rights><rights>Copyright 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c508t-76fb71f56dc5ef0834f6232e7ad8ea03ab9baf8b15f6a2c87837900c4e7064c73</citedby><cites>FETCH-LOGICAL-c508t-76fb71f56dc5ef0834f6232e7ad8ea03ab9baf8b15f6a2c87837900c4e7064c73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.fertnstert.2008.09.084$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,4024,27923,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22323598$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19027110$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Riggs, Ryan, M.D</creatorcontrib><creatorcontrib>Mayer, Jacob, Ph.D</creatorcontrib><creatorcontrib>Dowling-Lacey, Donna, M.S</creatorcontrib><creatorcontrib>Chi, Ting-Fing, Ph.D</creatorcontrib><creatorcontrib>Jones, Estella, M.S</creatorcontrib><creatorcontrib>Oehninger, Sergio, M.D., Ph.D</creatorcontrib><title>Does storage time influence postthaw survival and pregnancy outcome? An analysis of 11,768 cryopreserved human embryos</title><title>Fertility and sterility</title><addtitle>Fertil Steril</addtitle><description>Objective To evaluate the impact of cryopreservation storage duration on embryo survival, implantation competence, and pregnancy outcome. Design Retrospective study. Setting Academic tertiary-referral infertility center. Patient(s) In vitro fertilization patients and recipients of oocyte donation cycles who had cryopreserved embryos and underwent at least one thaw cycle from 1986 to 2007. Intervention(s) None. Main Outcome Measure(s) Postthaw survival proportion and implantation, clinical pregnancy, miscarriage, and live birth rates. Result(s) Length of storage time did not have a significant effect on postthaw survival for IVF or oocyte donation cycles, or for embryos frozen at the pronuclear or cleavage stages. There was no significant impact of the duration of storage on clinical pregnancy, miscarriage, implantation, or live birth rate, whether from IVF or oocyte donation cycles. Logistic regression analysis demonstrated that the length of storage time or developmental stage at freezing were not predictive of embryo survival or pregnancy outcome. Only oocyte age, survival proportion, and number of transferred embryos were positive predictors of pregnancy outcome. Conclusion(s) Cryostorage duration did not adversely affect postthaw survival or pregnancy outcome in IVF or oocyte donation patients.</description><subject>Abortion, Spontaneous</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Cryopreservation</subject><subject>Embryo cryopreservation</subject><subject>Embryo Implantation</subject><subject>Embryo Transfer</subject><subject>Embryo, Mammalian</subject><subject>Female</subject><subject>Fertilization in Vitro</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>implantation</subject><subject>Infertility - therapy</subject><subject>Internal Medicine</subject><subject>Live Birth</subject><subject>Logistic Models</subject><subject>Medical sciences</subject><subject>Obstetrics and Gynecology</subject><subject>Odds Ratio</subject><subject>Oocyte Donation</subject><subject>postthaw survival</subject><subject>Pregnancy</subject><subject>Pregnancy Outcome</subject><subject>Pregnancy Rate</subject><subject>Reproductive Techniques, Assisted - adverse effects</subject><subject>Retrospective Studies</subject><subject>storage time</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><issn>0015-0282</issn><issn>1556-5653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkkuP0zAQgCMEYsvCX0C-IC60jJ34kQtoWZ7SShyAs-U4412XJC6epKj_HletWIkTF1uyv5mxv5mqYhw2HLh6vd0EzPNEc1k3AsBsoN2AaR5UKy6lWksl64fVCoDLNQgjLqonRFsAUFyLx9UFb0FozmFV7d8nJEZzyu4W2RxHZHEKw4KTR7ZLNM937jejJe_j3g3MTT3bZbyd3OQPLC2zTyO-ZVdTuXHDgSKxFBjnr7QyzOdDKjBh3mPP7pbRTQzHrpzS0-pRcAPhs_N-Wf34-OH79ef1zddPX66vbtZegpnXWoVO8yBV7yUGMHUTlKgFatcbdFC7ru1cMB2XQTnhjTa1bgF8gxpU43V9Wb085d3l9GtBmu0YyeMwuAnTQlbXjZBtrZpCmhPpcyLKGOwux9Hlg-Vgj9Lt1t5Lt0fpFlpbpJfQ5-ciSzdifx94tlyAF2fAkXdDyMVepL-cKF-qZWsK9-7EYVGyj5gt-XjsRB8z-tn2Kf7Pa978k8QPcYql7k88IG3TkkuryHJLwoL9dhyS44yAgYYLYeo_BIi79g</recordid><startdate>2010</startdate><enddate>2010</enddate><creator>Riggs, Ryan, M.D</creator><creator>Mayer, Jacob, Ph.D</creator><creator>Dowling-Lacey, Donna, M.S</creator><creator>Chi, Ting-Fing, Ph.D</creator><creator>Jones, Estella, M.S</creator><creator>Oehninger, Sergio, M.D., Ph.D</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2010</creationdate><title>Does storage time influence postthaw survival and pregnancy outcome? An analysis of 11,768 cryopreserved human embryos</title><author>Riggs, Ryan, M.D ; Mayer, Jacob, Ph.D ; Dowling-Lacey, Donna, M.S ; Chi, Ting-Fing, Ph.D ; Jones, Estella, M.S ; Oehninger, Sergio, M.D., Ph.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c508t-76fb71f56dc5ef0834f6232e7ad8ea03ab9baf8b15f6a2c87837900c4e7064c73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Abortion, Spontaneous</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Cryopreservation</topic><topic>Embryo cryopreservation</topic><topic>Embryo Implantation</topic><topic>Embryo Transfer</topic><topic>Embryo, Mammalian</topic><topic>Female</topic><topic>Fertilization in Vitro</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>implantation</topic><topic>Infertility - therapy</topic><topic>Internal Medicine</topic><topic>Live Birth</topic><topic>Logistic Models</topic><topic>Medical sciences</topic><topic>Obstetrics and Gynecology</topic><topic>Odds Ratio</topic><topic>Oocyte Donation</topic><topic>postthaw survival</topic><topic>Pregnancy</topic><topic>Pregnancy Outcome</topic><topic>Pregnancy Rate</topic><topic>Reproductive Techniques, Assisted - adverse effects</topic><topic>Retrospective Studies</topic><topic>storage time</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Riggs, Ryan, M.D</creatorcontrib><creatorcontrib>Mayer, Jacob, Ph.D</creatorcontrib><creatorcontrib>Dowling-Lacey, Donna, M.S</creatorcontrib><creatorcontrib>Chi, Ting-Fing, Ph.D</creatorcontrib><creatorcontrib>Jones, Estella, M.S</creatorcontrib><creatorcontrib>Oehninger, Sergio, M.D., Ph.D</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Fertility and sterility</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Riggs, Ryan, M.D</au><au>Mayer, Jacob, Ph.D</au><au>Dowling-Lacey, Donna, M.S</au><au>Chi, Ting-Fing, Ph.D</au><au>Jones, Estella, M.S</au><au>Oehninger, Sergio, M.D., Ph.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Does storage time influence postthaw survival and pregnancy outcome? An analysis of 11,768 cryopreserved human embryos</atitle><jtitle>Fertility and sterility</jtitle><addtitle>Fertil Steril</addtitle><date>2010</date><risdate>2010</risdate><volume>93</volume><issue>1</issue><spage>109</spage><epage>115</epage><pages>109-115</pages><issn>0015-0282</issn><eissn>1556-5653</eissn><coden>FESTAS</coden><abstract>Objective To evaluate the impact of cryopreservation storage duration on embryo survival, implantation competence, and pregnancy outcome. Design Retrospective study. Setting Academic tertiary-referral infertility center. Patient(s) In vitro fertilization patients and recipients of oocyte donation cycles who had cryopreserved embryos and underwent at least one thaw cycle from 1986 to 2007. Intervention(s) None. Main Outcome Measure(s) Postthaw survival proportion and implantation, clinical pregnancy, miscarriage, and live birth rates. Result(s) Length of storage time did not have a significant effect on postthaw survival for IVF or oocyte donation cycles, or for embryos frozen at the pronuclear or cleavage stages. There was no significant impact of the duration of storage on clinical pregnancy, miscarriage, implantation, or live birth rate, whether from IVF or oocyte donation cycles. Logistic regression analysis demonstrated that the length of storage time or developmental stage at freezing were not predictive of embryo survival or pregnancy outcome. Only oocyte age, survival proportion, and number of transferred embryos were positive predictors of pregnancy outcome. Conclusion(s) Cryostorage duration did not adversely affect postthaw survival or pregnancy outcome in IVF or oocyte donation patients.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>19027110</pmid><doi>10.1016/j.fertnstert.2008.09.084</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0015-0282 |
| ispartof | Fertility and sterility, 2010, Vol.93 (1), p.109-115 |
| issn | 0015-0282 1556-5653 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_734259364 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; ScienceDirect Journals (5 years ago - present); Alma/SFX Local Collection |
| subjects | Abortion, Spontaneous Adult Biological and medical sciences Cryopreservation Embryo cryopreservation Embryo Implantation Embryo Transfer Embryo, Mammalian Female Fertilization in Vitro Gynecology. Andrology. Obstetrics Humans implantation Infertility - therapy Internal Medicine Live Birth Logistic Models Medical sciences Obstetrics and Gynecology Odds Ratio Oocyte Donation postthaw survival Pregnancy Pregnancy Outcome Pregnancy Rate Reproductive Techniques, Assisted - adverse effects Retrospective Studies storage time Time Factors Treatment Outcome |
| title | Does storage time influence postthaw survival and pregnancy outcome? An analysis of 11,768 cryopreserved human embryos |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T16%3A46%3A29IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Does%20storage%20time%20influence%20postthaw%20survival%20and%20pregnancy%20outcome?%20An%20analysis%20of%2011,768%20cryopreserved%20human%20embryos&rft.jtitle=Fertility%20and%20sterility&rft.au=Riggs,%20Ryan,%20M.D&rft.date=2010&rft.volume=93&rft.issue=1&rft.spage=109&rft.epage=115&rft.pages=109-115&rft.issn=0015-0282&rft.eissn=1556-5653&rft.coden=FESTAS&rft_id=info:doi/10.1016/j.fertnstert.2008.09.084&rft_dat=%3Cproquest_cross%3E734259364%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=734259364&rft_id=info:pmid/19027110&rft_els_id=1_s2_0_S0015028208041228&rfr_iscdi=true |