A new Factor Xa inhibitor from Amblyomma cajennense with a unique domain composition

Bioactive compounds of great interest are found in the saliva of hematophagous organisms. While exploring a cDNA library derived from the salivary glands of the tick Amblyomma cajennense, a transcript that codes for a protein with unique structure (containing an N-terminal Kunitz-type domain and a C...

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Veröffentlicht in:	Archives of biochemistry and biophysics 2010-01, Vol.493 (2), p.151-156
Hauptverfasser:	Batista, I.F.C., Ramos, O.H.P., Ventura, J.S., Junqueira-de-Azevedo, I.L.M., Ho, P.L., Chudzinski-Tavassi, A.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amblyomma cajennense Animals Anticoagulant Cloning, Molecular DNA, Complementary - genetics Escherichia Factor Xa - chemistry Factor Xa - metabolism Factor Xa Inhibitors FXa inhibitor Humans Ixodidae Ixodidae - chemistry Ixodidae - genetics Ixodidae - metabolism Kunitz Molecular dynamics Molecular modeling Protein Structure, Tertiary - physiology Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism Serine Proteinase Inhibitors - chemistry Serine Proteinase Inhibitors - genetics Serine Proteinase Inhibitors - metabolism Structure-Activity Relationship
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