Xenopus Meis3 protein lies at a nexus downstream to Zic1 and Pax3 proteins, regulating multiple cell-fates during early nervous system development

In Xenopus embryos, XMeis3 protein activity is required for normal hindbrain formation. Our results show that XMeis3 protein knock down also causes a loss of primary neuron and neural crest cell lineages, without altering expression of Zic, Sox or Pax3 genes. Knock down or inhibition of the Pax3, Zi...

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Veröffentlicht in:	Developmental biology 2010-02, Vol.338 (1), p.50-62
Hauptverfasser:	Gutkovich, Yoni E., Ofir, Rachel, Elkouby, Yaniv M., Dibner, Charna, Gefen, Aharon, Elias, Sarah, Frank, Dale
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Basic Helix-Loop-Helix Transcription Factors - genetics Basic Helix-Loop-Helix Transcription Factors - metabolism Biomarkers - metabolism Cell Lineage Embryo, Nonmammalian - cytology Embryo, Nonmammalian - metabolism FGF Fibroblast Growth Factor 3 - metabolism Fibroblast Growth Factor 8 - metabolism Freshwater Gene Expression Regulation, Developmental Gene Knockdown Techniques Genes, Dominant - genetics Hindbrain Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Nervous System - cytology Nervous System - embryology Nervous System - metabolism Neural crest Neural Crest - cytology Neural Crest - embryology Neural Crest - metabolism Neurons - cytology Neurons - metabolism Paired Box Transcription Factors - genetics Paired Box Transcription Factors - metabolism Pax3 PAX3 Transcription Factor Phenotype Primary neurons Transcription Factors - genetics Transcription Factors - metabolism Xenopus Xenopus laevis - embryology Xenopus laevis - genetics Xenopus Proteins - genetics Xenopus Proteins - metabolism XMeis3 Zic1
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