Molecular and Metabolic Evidence for Mitochondrial Defects Associated With β-Cell Dysfunction in a Mouse Model of Type 2 Diabetes

Molecular and Metabolic Evidence for Mitochondrial Defects Associated With β-Cell Dysfunction in a Mouse Model of Type 2 Diabetes Hongfang Lu , Vasilij Koshkin , Emma M. Allister , Armen V. Gyulkhandanyan and Michael B. Wheeler From the Departments of Physiology and Medicine, Faculty of Medicine, Un...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2010-02, Vol.59 (2), p.448-459
Hauptverfasser:	Lu, Hongfang, Koshkin, Vasilij, Allister, Emma M, Gyulkhandanyan, Armen V, Wheeler, Michael B
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Diphosphate - metabolism Adenosine Triphosphate - metabolism Animals Biological and medical sciences Blood Glucose - metabolism Calcium - metabolism Cytochrome c Dextrose Diabetes Mellitus, Type 2 - genetics Diabetes Mellitus, Type 2 - metabolism Diabetes. Impaired glucose tolerance Disease Models, Animal DNA, Mitochondrial - genetics Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Glucose Humans Hyperglycemia Hyperglycemia - complications Hyperglycemia - physiopathology Insulin - metabolism Insulin resistance Insulin Resistance - physiology Insulin Secretion Insulin-Secreting Cells - pathology Insulin-Secreting Cells - physiology Medical sciences Membrane Potentials - physiology Membrane proteins Mice Mice, Inbred Strains Mice, Transgenic Mitochondria - pathology Mitochondrial DNA Original Oxidative Phosphorylation Oxidative Stress - physiology Pancreatic beta cells Physiological aspects Proteins - genetics Reverse Transcriptase Polymerase Chain Reaction RNA, Ribosomal - genetics RNA, Ribosomal - isolation & purification Type 2 diabetes
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