Several common variants modulate heart rate, PR interval and QRS duration

Hilma Holm and colleagues report genome-wide association studies to electrocardiographic measures of heart rate, PR interval, QRS duration and QT interval. Electrocardiographic measures are indicative of the function of the cardiac conduction system. To search for sequence variants that modulate hea...

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Veröffentlicht in:	Nature genetics 2010-02, Vol.42 (2), p.117-122
Hauptverfasser:	Holm, Hilma, Gudbjartsson, Daniel F, Arnar, David O, Thorleifsson, Gudmar, Thorgeirsson, Gudmundur, Stefansdottir, Hrafnhildur, Gudjonsson, Sigurjon A, Jonasdottir, Aslaug, Mathiesen, Ellisiv B, Njølstad, Inger, Nyrnes, Audhild, Wilsgaard, Tom, Hald, Erin M, Hveem, Kristian, Stoltenberg, Camilla, Løchen, Maja-Lisa, Kong, Augustine, Thorsteinsdottir, Unnur, Stefansson, Kari
Format:	Artikel
Sprache:	eng
Schlagworte:	631/1647/2204/1453/1448 631/208/205/2138 631/208/727/2000 692/699/75/29 Aged Agriculture Animal Genetics and Genomics Arrhythmias, Cardiac - complications Arrhythmias, Cardiac - genetics Arrhythmias, Cardiac - physiopathology Atrial fibrillation Atrial Fibrillation - complications Atrial Fibrillation - genetics Atrial Fibrillation - physiopathology Atrioventricular Block - complications Atrioventricular Block - genetics Atrioventricular Block - physiopathology Biological and medical sciences Biomedical and Life Sciences Biomedicine Cancer Research Cardiac arrhythmia Cardiac Myosins - genetics Cardiovascular disease Care and treatment Data collection Diagnosis Electrocardiogram Electrocardiography Female Fundamental and applied biological sciences. Psychology Gene expression Gene Function Genetic aspects Genetic Loci - genetics Genetic Variation Genetics of eukaryotes. Biological and molecular evolution Genome-Wide Association Study Health aspects Heart attacks Heart beat Heart Conduction System - physiology Heart rate Heart Rate - genetics Human Genetics Humans Iceland Inheritance Patterns - genetics Male Measurement Middle Aged Mortality Myosin Heavy Chains - genetics Nitric oxide Pacemaker, Artificial Physiological aspects Reproducibility of Results Risk factors Sick Sinus Syndrome - complications Sick Sinus Syndrome - genetics Sick Sinus Syndrome - physiopathology Studies
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