Apoptosis of glomerular mesangial cells induced by sublytic C5b‐9 complexes in rats with Thy‐1 nephritis is dependent on Gadd45γ upregulation

The complement C5b‐9 complexes can result in cell apoptosis, but the mechanism of sublytic C5b‐9‐mediated glomerular mesangial cell (GMC) apoptosis in Thy‐1 nephritis (Thy‐1N) remains largely unclear. The Gadd45 gene is involved in the cellular response to DNA damage and can promote cell apoptosis....

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	European journal of immunology 2009-11, Vol.39 (11), p.3251-3266
Hauptverfasser:	Qiu, Wen, Che, Nan, Feng, Xuefeng, Xia, Mei, Wang, Hui, Zhao, Dan, Wang, Yingwei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - immunology Blotting, Western Cell Separation Complement Membrane Attack Complex - immunology Flow Cytometry Fluorescent Antibody Technique GADD45 Proteins Gadd45γ Gene Expression Glomerular mesangial cells In Situ Nick-End Labeling Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - immunology Mesangial Cells - pathology Nephritis - immunology Nephritis - pathology Rats Reverse Transcriptase Polymerase Chain Reaction RNA, Small Interfering Sublytic C5b‐9 Thy-1 Antigens - immunology Thy‐1 nephritis Transfection Up-Regulation
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!