Amniotic fluid markers of fetal cardiac dysfunction in twin-to-twin transfusion syndrome
Objective The objective of the study was to determine whether cardiac troponin T (cTnT) and natriuretic peptides can be isolated from the amniotic fluid (AF) of pregnancies complicated by twin-to-twin transfusion syndrome (TTTS) and whether they correlate with fetal echocardiographic findings and re...
Gespeichert in:
| Veröffentlicht in: | American journal of obstetrics and gynecology 2010, Vol.202 (1), p.48.e1-48.e7 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 48.e7 |
|---|---|
| container_issue | 1 |
| container_start_page | 48.e1 |
| container_title | American journal of obstetrics and gynecology |
| container_volume | 202 |
| creator | Van Mieghem, Tim, MD Doné, Elisa, MD Gucciardo, Léonardo, MD Klaritsch, Philipp, MD Allegaert, Karel, MD, PhD Van Bree, Rita Lewi, Liesbeth, MD, PhD Deprest, Jan, MD, PhD |
| description | Objective The objective of the study was to determine whether cardiac troponin T (cTnT) and natriuretic peptides can be isolated from the amniotic fluid (AF) of pregnancies complicated by twin-to-twin transfusion syndrome (TTTS) and whether they correlate with fetal echocardiographic findings and recipient survival. Study Design AF samples from the recipient sac were obtained in 52 TTTS cases and 16 controls. Samples were assayed for cTnT and natriuretic peptides. Prior to fetoscopic laser therapy, 34 recipient twins underwent assessment of atrioventricular flow patterns, myocardial performance index (MPI), and precordial venous Dopplers. Fetal survival was assessed 48 hours postoperatively. Results AF B-type natriuretic peptide and cTnT levels were elevated in TTTS and correlated with functional echocardiographic findings. Postoperative recipient survival was 72% when both AF-cTnT and left ventricular MPI were increased. If 1 of both markers was normal, survival was 100% ( P = .046). Conclusion Combining ultrasound and AF-cTnT measurements allows the identification of fetuses at risk of postoperative demise. |
| doi_str_mv | 10.1016/j.ajog.2009.08.013 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_734256679</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0002937809009193</els_id><sourcerecordid>734256679</sourcerecordid><originalsourceid>FETCH-LOGICAL-c506t-abb9abc739397a3de5c65fc959f6412bda19fbe51f2a8077f3bc26c4afe0b9833</originalsourceid><addsrcrecordid>eNp9kU2L1TAUhoMoznX0D7iQbMRVaz7apAERhsEvGHChgruQJieSTpuMSetw_70p96LgwtUhnOc9SZ6D0HNKWkqoeD21Zko_WkaIasnQEsofoAMlSjZiEMNDdCCEsEZxOVygJ6VM-5Ep9hhdUDUQSrvugL5fLTGkNVjs5y04vJh8C7ng5LGH1czYmuyCsdgdi9-iXUOKOES83ofYrKnZK16zibVb9l45RpfTAk_RI2_mAs_O9RJ9e__u6_XH5ubzh0_XVzeN7YlYGzOOyoxWcsWVNNxBb0XvreqVFx1lozNU-RF66pkZiJSej5YJ2xkPZFQD55fo1WnuXU4_NyirXkKxMM8mQtqKlrxjvRBSVZKdSJtTKRm8vsuh_veoKdG7UD3pXajehWoy6Cq0hl6cx2_jAu5v5GywAi_PgCnWzL6qsKH84RjjnRSDrNybEwdVxq8AWRcbIFpwIYNdtUvh_-94-0_cziGGeuMtHKFMacuxatZUF6aJ_rLvet88UXUIVZz_Bu5GqoI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>734256679</pqid></control><display><type>article</type><title>Amniotic fluid markers of fetal cardiac dysfunction in twin-to-twin transfusion syndrome</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Van Mieghem, Tim, MD ; Doné, Elisa, MD ; Gucciardo, Léonardo, MD ; Klaritsch, Philipp, MD ; Allegaert, Karel, MD, PhD ; Van Bree, Rita ; Lewi, Liesbeth, MD, PhD ; Deprest, Jan, MD, PhD</creator><creatorcontrib>Van Mieghem, Tim, MD ; Doné, Elisa, MD ; Gucciardo, Léonardo, MD ; Klaritsch, Philipp, MD ; Allegaert, Karel, MD, PhD ; Van Bree, Rita ; Lewi, Liesbeth, MD, PhD ; Deprest, Jan, MD, PhD</creatorcontrib><description>Objective The objective of the study was to determine whether cardiac troponin T (cTnT) and natriuretic peptides can be isolated from the amniotic fluid (AF) of pregnancies complicated by twin-to-twin transfusion syndrome (TTTS) and whether they correlate with fetal echocardiographic findings and recipient survival. Study Design AF samples from the recipient sac were obtained in 52 TTTS cases and 16 controls. Samples were assayed for cTnT and natriuretic peptides. Prior to fetoscopic laser therapy, 34 recipient twins underwent assessment of atrioventricular flow patterns, myocardial performance index (MPI), and precordial venous Dopplers. Fetal survival was assessed 48 hours postoperatively. Results AF B-type natriuretic peptide and cTnT levels were elevated in TTTS and correlated with functional echocardiographic findings. Postoperative recipient survival was 72% when both AF-cTnT and left ventricular MPI were increased. If 1 of both markers was normal, survival was 100% ( P = .046). Conclusion Combining ultrasound and AF-cTnT measurements allows the identification of fetuses at risk of postoperative demise.</description><identifier>ISSN: 0002-9378</identifier><identifier>EISSN: 1097-6868</identifier><identifier>DOI: 10.1016/j.ajog.2009.08.013</identifier><identifier>PMID: 19801144</identifier><identifier>CODEN: AJOGAH</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Adult ; Amniotic Fluid - chemistry ; Atrial Natriuretic Factor - analysis ; Biological and medical sciences ; Biomarkers - analysis ; Diseases of mother, fetus and pregnancy ; echocardiography ; Female ; fetal surgery ; Fetofetal Transfusion - diagnosis ; Fetofetal Transfusion - mortality ; Fetofetal Transfusion - physiopathology ; Gynecology. Andrology. Obstetrics ; Humans ; Medical sciences ; natriuretic peptide ; Natriuretic Peptide, Brain - analysis ; Obstetrics and Gynecology ; Pregnancy ; Pregnancy Outcome ; Pregnancy. Fetus. Placenta ; troponin ; Troponin T - analysis ; twin-to-twin transfusion ; Ultrasonography, Prenatal ; Ventricular Function, Left</subject><ispartof>American journal of obstetrics and gynecology, 2010, Vol.202 (1), p.48.e1-48.e7</ispartof><rights>Mosby, Inc.</rights><rights>2010 Mosby, Inc.</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c506t-abb9abc739397a3de5c65fc959f6412bda19fbe51f2a8077f3bc26c4afe0b9833</citedby><cites>FETCH-LOGICAL-c506t-abb9abc739397a3de5c65fc959f6412bda19fbe51f2a8077f3bc26c4afe0b9833</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ajog.2009.08.013$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,4024,27923,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22347687$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19801144$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Van Mieghem, Tim, MD</creatorcontrib><creatorcontrib>Doné, Elisa, MD</creatorcontrib><creatorcontrib>Gucciardo, Léonardo, MD</creatorcontrib><creatorcontrib>Klaritsch, Philipp, MD</creatorcontrib><creatorcontrib>Allegaert, Karel, MD, PhD</creatorcontrib><creatorcontrib>Van Bree, Rita</creatorcontrib><creatorcontrib>Lewi, Liesbeth, MD, PhD</creatorcontrib><creatorcontrib>Deprest, Jan, MD, PhD</creatorcontrib><title>Amniotic fluid markers of fetal cardiac dysfunction in twin-to-twin transfusion syndrome</title><title>American journal of obstetrics and gynecology</title><addtitle>Am J Obstet Gynecol</addtitle><description>Objective The objective of the study was to determine whether cardiac troponin T (cTnT) and natriuretic peptides can be isolated from the amniotic fluid (AF) of pregnancies complicated by twin-to-twin transfusion syndrome (TTTS) and whether they correlate with fetal echocardiographic findings and recipient survival. Study Design AF samples from the recipient sac were obtained in 52 TTTS cases and 16 controls. Samples were assayed for cTnT and natriuretic peptides. Prior to fetoscopic laser therapy, 34 recipient twins underwent assessment of atrioventricular flow patterns, myocardial performance index (MPI), and precordial venous Dopplers. Fetal survival was assessed 48 hours postoperatively. Results AF B-type natriuretic peptide and cTnT levels were elevated in TTTS and correlated with functional echocardiographic findings. Postoperative recipient survival was 72% when both AF-cTnT and left ventricular MPI were increased. If 1 of both markers was normal, survival was 100% ( P = .046). Conclusion Combining ultrasound and AF-cTnT measurements allows the identification of fetuses at risk of postoperative demise.</description><subject>Adult</subject><subject>Amniotic Fluid - chemistry</subject><subject>Atrial Natriuretic Factor - analysis</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - analysis</subject><subject>Diseases of mother, fetus and pregnancy</subject><subject>echocardiography</subject><subject>Female</subject><subject>fetal surgery</subject><subject>Fetofetal Transfusion - diagnosis</subject><subject>Fetofetal Transfusion - mortality</subject><subject>Fetofetal Transfusion - physiopathology</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>natriuretic peptide</subject><subject>Natriuretic Peptide, Brain - analysis</subject><subject>Obstetrics and Gynecology</subject><subject>Pregnancy</subject><subject>Pregnancy Outcome</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>troponin</subject><subject>Troponin T - analysis</subject><subject>twin-to-twin transfusion</subject><subject>Ultrasonography, Prenatal</subject><subject>Ventricular Function, Left</subject><issn>0002-9378</issn><issn>1097-6868</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU2L1TAUhoMoznX0D7iQbMRVaz7apAERhsEvGHChgruQJieSTpuMSetw_70p96LgwtUhnOc9SZ6D0HNKWkqoeD21Zko_WkaIasnQEsofoAMlSjZiEMNDdCCEsEZxOVygJ6VM-5Ep9hhdUDUQSrvugL5fLTGkNVjs5y04vJh8C7ng5LGH1czYmuyCsdgdi9-iXUOKOES83ofYrKnZK16zibVb9l45RpfTAk_RI2_mAs_O9RJ9e__u6_XH5ubzh0_XVzeN7YlYGzOOyoxWcsWVNNxBb0XvreqVFx1lozNU-RF66pkZiJSej5YJ2xkPZFQD55fo1WnuXU4_NyirXkKxMM8mQtqKlrxjvRBSVZKdSJtTKRm8vsuh_veoKdG7UD3pXajehWoy6Cq0hl6cx2_jAu5v5GywAi_PgCnWzL6qsKH84RjjnRSDrNybEwdVxq8AWRcbIFpwIYNdtUvh_-94-0_cziGGeuMtHKFMacuxatZUF6aJ_rLvet88UXUIVZz_Bu5GqoI</recordid><startdate>2010</startdate><enddate>2010</enddate><creator>Van Mieghem, Tim, MD</creator><creator>Doné, Elisa, MD</creator><creator>Gucciardo, Léonardo, MD</creator><creator>Klaritsch, Philipp, MD</creator><creator>Allegaert, Karel, MD, PhD</creator><creator>Van Bree, Rita</creator><creator>Lewi, Liesbeth, MD, PhD</creator><creator>Deprest, Jan, MD, PhD</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2010</creationdate><title>Amniotic fluid markers of fetal cardiac dysfunction in twin-to-twin transfusion syndrome</title><author>Van Mieghem, Tim, MD ; Doné, Elisa, MD ; Gucciardo, Léonardo, MD ; Klaritsch, Philipp, MD ; Allegaert, Karel, MD, PhD ; Van Bree, Rita ; Lewi, Liesbeth, MD, PhD ; Deprest, Jan, MD, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c506t-abb9abc739397a3de5c65fc959f6412bda19fbe51f2a8077f3bc26c4afe0b9833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Amniotic Fluid - chemistry</topic><topic>Atrial Natriuretic Factor - analysis</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - analysis</topic><topic>Diseases of mother, fetus and pregnancy</topic><topic>echocardiography</topic><topic>Female</topic><topic>fetal surgery</topic><topic>Fetofetal Transfusion - diagnosis</topic><topic>Fetofetal Transfusion - mortality</topic><topic>Fetofetal Transfusion - physiopathology</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>natriuretic peptide</topic><topic>Natriuretic Peptide, Brain - analysis</topic><topic>Obstetrics and Gynecology</topic><topic>Pregnancy</topic><topic>Pregnancy Outcome</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>troponin</topic><topic>Troponin T - analysis</topic><topic>twin-to-twin transfusion</topic><topic>Ultrasonography, Prenatal</topic><topic>Ventricular Function, Left</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Van Mieghem, Tim, MD</creatorcontrib><creatorcontrib>Doné, Elisa, MD</creatorcontrib><creatorcontrib>Gucciardo, Léonardo, MD</creatorcontrib><creatorcontrib>Klaritsch, Philipp, MD</creatorcontrib><creatorcontrib>Allegaert, Karel, MD, PhD</creatorcontrib><creatorcontrib>Van Bree, Rita</creatorcontrib><creatorcontrib>Lewi, Liesbeth, MD, PhD</creatorcontrib><creatorcontrib>Deprest, Jan, MD, PhD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of obstetrics and gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Van Mieghem, Tim, MD</au><au>Doné, Elisa, MD</au><au>Gucciardo, Léonardo, MD</au><au>Klaritsch, Philipp, MD</au><au>Allegaert, Karel, MD, PhD</au><au>Van Bree, Rita</au><au>Lewi, Liesbeth, MD, PhD</au><au>Deprest, Jan, MD, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Amniotic fluid markers of fetal cardiac dysfunction in twin-to-twin transfusion syndrome</atitle><jtitle>American journal of obstetrics and gynecology</jtitle><addtitle>Am J Obstet Gynecol</addtitle><date>2010</date><risdate>2010</risdate><volume>202</volume><issue>1</issue><spage>48.e1</spage><epage>48.e7</epage><pages>48.e1-48.e7</pages><issn>0002-9378</issn><eissn>1097-6868</eissn><coden>AJOGAH</coden><abstract>Objective The objective of the study was to determine whether cardiac troponin T (cTnT) and natriuretic peptides can be isolated from the amniotic fluid (AF) of pregnancies complicated by twin-to-twin transfusion syndrome (TTTS) and whether they correlate with fetal echocardiographic findings and recipient survival. Study Design AF samples from the recipient sac were obtained in 52 TTTS cases and 16 controls. Samples were assayed for cTnT and natriuretic peptides. Prior to fetoscopic laser therapy, 34 recipient twins underwent assessment of atrioventricular flow patterns, myocardial performance index (MPI), and precordial venous Dopplers. Fetal survival was assessed 48 hours postoperatively. Results AF B-type natriuretic peptide and cTnT levels were elevated in TTTS and correlated with functional echocardiographic findings. Postoperative recipient survival was 72% when both AF-cTnT and left ventricular MPI were increased. If 1 of both markers was normal, survival was 100% ( P = .046). Conclusion Combining ultrasound and AF-cTnT measurements allows the identification of fetuses at risk of postoperative demise.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>19801144</pmid><doi>10.1016/j.ajog.2009.08.013</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-9378 |
| ispartof | American journal of obstetrics and gynecology, 2010, Vol.202 (1), p.48.e1-48.e7 |
| issn | 0002-9378 1097-6868 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_734256679 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adult Amniotic Fluid - chemistry Atrial Natriuretic Factor - analysis Biological and medical sciences Biomarkers - analysis Diseases of mother, fetus and pregnancy echocardiography Female fetal surgery Fetofetal Transfusion - diagnosis Fetofetal Transfusion - mortality Fetofetal Transfusion - physiopathology Gynecology. Andrology. Obstetrics Humans Medical sciences natriuretic peptide Natriuretic Peptide, Brain - analysis Obstetrics and Gynecology Pregnancy Pregnancy Outcome Pregnancy. Fetus. Placenta troponin Troponin T - analysis twin-to-twin transfusion Ultrasonography, Prenatal Ventricular Function, Left |
| title | Amniotic fluid markers of fetal cardiac dysfunction in twin-to-twin transfusion syndrome |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-21T01%3A42%3A34IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Amniotic%20fluid%20markers%20of%20fetal%20cardiac%20dysfunction%20in%20twin-to-twin%20transfusion%20syndrome&rft.jtitle=American%20journal%20of%20obstetrics%20and%20gynecology&rft.au=Van%20Mieghem,%20Tim,%20MD&rft.date=2010&rft.volume=202&rft.issue=1&rft.spage=48.e1&rft.epage=48.e7&rft.pages=48.e1-48.e7&rft.issn=0002-9378&rft.eissn=1097-6868&rft.coden=AJOGAH&rft_id=info:doi/10.1016/j.ajog.2009.08.013&rft_dat=%3Cproquest_cross%3E734256679%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=734256679&rft_id=info:pmid/19801144&rft_els_id=S0002937809009193&rfr_iscdi=true |