Association between prepregnancy body mass index and congenital heart defects
Objective The purpose of this study was to examine associations between prepregnancy body mass index (BMI) and congenital heart defects (CHDs). Study Design These analyses included case infants with CHDs (n = 6440) and liveborn control infants without birth defects (n = 5673) enrolled in the Nationa...
Gespeichert in:
| Veröffentlicht in: | American journal of obstetrics and gynecology 2010, Vol.202 (1), p.51.e1-51.e10 |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 51.e10 |
|---|---|
| container_issue | 1 |
| container_start_page | 51.e1 |
| container_title | American journal of obstetrics and gynecology |
| container_volume | 202 |
| creator | Gilboa, Suzanne M., PhD Correa, Adolfo, MD, PhD Botto, Lorenzo D., MD Rasmussen, Sonja A., MD, MS Waller, D. Kim, PhD Hobbs, Charlotte A., MD, PhD Cleves, Mario A., PhD Riehle-Colarusso, Tiffany J., MD, MSE |
| description | Objective The purpose of this study was to examine associations between prepregnancy body mass index (BMI) and congenital heart defects (CHDs). Study Design These analyses included case infants with CHDs (n = 6440) and liveborn control infants without birth defects (n = 5673) enrolled in the National Birth Defects Prevention Study (1997-2004). Results Adjusted odds ratios for all CHDs combined were 1.16 (95% confidence interval [CI], 1.05–1.29), 1.15 (95% CI, 1.00–1.32), and 1.31 (95% CI, 1.11–1.56) for overweight status, moderate obesity, and severe obesity, respectively. Phenotypes associated with elevated BMI (≥25.0 kg/m2 ) were conotruncal defects (tetralogy of Fallot), total anomalous pulmonary venous return, hypoplastic left heart syndrome, right ventricular outflow tract (RVOT) defects (pulmonary valve stenosis), and septal defects (secundum atrial septal defect). Conclusion These results corroborated those of previous studies and suggested new associations between obesity and conotruncal defects and RVOT defects. |
| doi_str_mv | 10.1016/j.ajog.2009.08.005 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_734254054</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S000293780900903X</els_id><sourcerecordid>734254054</sourcerecordid><originalsourceid>FETCH-LOGICAL-c465t-52e989c2ef61f06d79b6ad2fa6e500f36628c6deb09fdda98391a5aa3306a1b23</originalsourceid><addsrcrecordid>eNp9kdGK1DAUhoMo7uzqC3ghvRGvWk-SNk1AhGXRVVjxQgXvQpqcjqmdZEw66ry9KTMoeCEEQuD7_xy-Q8gTCg0FKl5MjZnitmEAqgHZAHT3yIaC6mshhbxPNgDAasV7eUEuc57WJ1PsIbmgqlei77oNeX-dc7TeLD6GasDlJ2Ko9gnL2QYT7LEaojtWO5Nz5YPDX5UJrrIxbDH4xczVVzRpqRyOaJf8iDwYzZzx8fm-Ip_fvP5087a--3D77ub6rrat6Ja6Y6iksgxHQUcQrleDMI6NRmAHMHIhmLTC4QBqdM4oyRU1nTGcgzB0YPyKPD_17lP8fsC86J3PFufZBIyHrHvesq6Fri0kO5E2xZwTjnqf_M6ko6agV4t60qtFvVrUIHWxWEJPz_WHYYfub-SsrQDPzoDJ1sxjKqZ8_sMxxtteSFm4lycOi4wfHpPO1mOw6HwqvrSL_v9zvPonbmcffPnxGx4xT_GQQtGsqc5Mg_64LnhdN6hSAvwL_w2sbKXX</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>734254054</pqid></control><display><type>article</type><title>Association between prepregnancy body mass index and congenital heart defects</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Gilboa, Suzanne M., PhD ; Correa, Adolfo, MD, PhD ; Botto, Lorenzo D., MD ; Rasmussen, Sonja A., MD, MS ; Waller, D. Kim, PhD ; Hobbs, Charlotte A., MD, PhD ; Cleves, Mario A., PhD ; Riehle-Colarusso, Tiffany J., MD, MSE</creator><creatorcontrib>Gilboa, Suzanne M., PhD ; Correa, Adolfo, MD, PhD ; Botto, Lorenzo D., MD ; Rasmussen, Sonja A., MD, MS ; Waller, D. Kim, PhD ; Hobbs, Charlotte A., MD, PhD ; Cleves, Mario A., PhD ; Riehle-Colarusso, Tiffany J., MD, MSE ; National Birth Defects Prevention Study</creatorcontrib><description>Objective The purpose of this study was to examine associations between prepregnancy body mass index (BMI) and congenital heart defects (CHDs). Study Design These analyses included case infants with CHDs (n = 6440) and liveborn control infants without birth defects (n = 5673) enrolled in the National Birth Defects Prevention Study (1997-2004). Results Adjusted odds ratios for all CHDs combined were 1.16 (95% confidence interval [CI], 1.05–1.29), 1.15 (95% CI, 1.00–1.32), and 1.31 (95% CI, 1.11–1.56) for overweight status, moderate obesity, and severe obesity, respectively. Phenotypes associated with elevated BMI (≥25.0 kg/m2 ) were conotruncal defects (tetralogy of Fallot), total anomalous pulmonary venous return, hypoplastic left heart syndrome, right ventricular outflow tract (RVOT) defects (pulmonary valve stenosis), and septal defects (secundum atrial septal defect). Conclusion These results corroborated those of previous studies and suggested new associations between obesity and conotruncal defects and RVOT defects.</description><identifier>ISSN: 0002-9378</identifier><identifier>EISSN: 1097-6868</identifier><identifier>DOI: 10.1016/j.ajog.2009.08.005</identifier><identifier>PMID: 19796755</identifier><identifier>CODEN: AJOGAH</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Biological and medical sciences ; Body Mass Index ; congenital heart defects ; Diabetes, Gestational - epidemiology ; Female ; gestational diabetes ; Gynecology. Andrology. Obstetrics ; Heart Defects, Congenital - epidemiology ; Humans ; Medical sciences ; obesity ; Obesity - epidemiology ; Obstetrics and Gynecology ; Odds Ratio ; Pregnancy ; Pregnancy Complications - epidemiology ; Risk Factors</subject><ispartof>American journal of obstetrics and gynecology, 2010, Vol.202 (1), p.51.e1-51.e10</ispartof><rights>2010</rights><rights>2015 INIST-CNRS</rights><rights>Published by Mosby, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c465t-52e989c2ef61f06d79b6ad2fa6e500f36628c6deb09fdda98391a5aa3306a1b23</citedby><cites>FETCH-LOGICAL-c465t-52e989c2ef61f06d79b6ad2fa6e500f36628c6deb09fdda98391a5aa3306a1b23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ajog.2009.08.005$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>309,310,314,777,781,786,787,3537,4010,4036,4037,23911,23912,25121,27904,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22347688$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19796755$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gilboa, Suzanne M., PhD</creatorcontrib><creatorcontrib>Correa, Adolfo, MD, PhD</creatorcontrib><creatorcontrib>Botto, Lorenzo D., MD</creatorcontrib><creatorcontrib>Rasmussen, Sonja A., MD, MS</creatorcontrib><creatorcontrib>Waller, D. Kim, PhD</creatorcontrib><creatorcontrib>Hobbs, Charlotte A., MD, PhD</creatorcontrib><creatorcontrib>Cleves, Mario A., PhD</creatorcontrib><creatorcontrib>Riehle-Colarusso, Tiffany J., MD, MSE</creatorcontrib><creatorcontrib>National Birth Defects Prevention Study</creatorcontrib><title>Association between prepregnancy body mass index and congenital heart defects</title><title>American journal of obstetrics and gynecology</title><addtitle>Am J Obstet Gynecol</addtitle><description>Objective The purpose of this study was to examine associations between prepregnancy body mass index (BMI) and congenital heart defects (CHDs). Study Design These analyses included case infants with CHDs (n = 6440) and liveborn control infants without birth defects (n = 5673) enrolled in the National Birth Defects Prevention Study (1997-2004). Results Adjusted odds ratios for all CHDs combined were 1.16 (95% confidence interval [CI], 1.05–1.29), 1.15 (95% CI, 1.00–1.32), and 1.31 (95% CI, 1.11–1.56) for overweight status, moderate obesity, and severe obesity, respectively. Phenotypes associated with elevated BMI (≥25.0 kg/m2 ) were conotruncal defects (tetralogy of Fallot), total anomalous pulmonary venous return, hypoplastic left heart syndrome, right ventricular outflow tract (RVOT) defects (pulmonary valve stenosis), and septal defects (secundum atrial septal defect). Conclusion These results corroborated those of previous studies and suggested new associations between obesity and conotruncal defects and RVOT defects.</description><subject>Biological and medical sciences</subject><subject>Body Mass Index</subject><subject>congenital heart defects</subject><subject>Diabetes, Gestational - epidemiology</subject><subject>Female</subject><subject>gestational diabetes</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Heart Defects, Congenital - epidemiology</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>obesity</subject><subject>Obesity - epidemiology</subject><subject>Obstetrics and Gynecology</subject><subject>Odds Ratio</subject><subject>Pregnancy</subject><subject>Pregnancy Complications - epidemiology</subject><subject>Risk Factors</subject><issn>0002-9378</issn><issn>1097-6868</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kdGK1DAUhoMo7uzqC3ghvRGvWk-SNk1AhGXRVVjxQgXvQpqcjqmdZEw66ry9KTMoeCEEQuD7_xy-Q8gTCg0FKl5MjZnitmEAqgHZAHT3yIaC6mshhbxPNgDAasV7eUEuc57WJ1PsIbmgqlei77oNeX-dc7TeLD6GasDlJ2Ko9gnL2QYT7LEaojtWO5Nz5YPDX5UJrrIxbDH4xczVVzRpqRyOaJf8iDwYzZzx8fm-Ip_fvP5087a--3D77ub6rrat6Ja6Y6iksgxHQUcQrleDMI6NRmAHMHIhmLTC4QBqdM4oyRU1nTGcgzB0YPyKPD_17lP8fsC86J3PFufZBIyHrHvesq6Fri0kO5E2xZwTjnqf_M6ko6agV4t60qtFvVrUIHWxWEJPz_WHYYfub-SsrQDPzoDJ1sxjKqZ8_sMxxtteSFm4lycOi4wfHpPO1mOw6HwqvrSL_v9zvPonbmcffPnxGx4xT_GQQtGsqc5Mg_64LnhdN6hSAvwL_w2sbKXX</recordid><startdate>2010</startdate><enddate>2010</enddate><creator>Gilboa, Suzanne M., PhD</creator><creator>Correa, Adolfo, MD, PhD</creator><creator>Botto, Lorenzo D., MD</creator><creator>Rasmussen, Sonja A., MD, MS</creator><creator>Waller, D. Kim, PhD</creator><creator>Hobbs, Charlotte A., MD, PhD</creator><creator>Cleves, Mario A., PhD</creator><creator>Riehle-Colarusso, Tiffany J., MD, MSE</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2010</creationdate><title>Association between prepregnancy body mass index and congenital heart defects</title><author>Gilboa, Suzanne M., PhD ; Correa, Adolfo, MD, PhD ; Botto, Lorenzo D., MD ; Rasmussen, Sonja A., MD, MS ; Waller, D. Kim, PhD ; Hobbs, Charlotte A., MD, PhD ; Cleves, Mario A., PhD ; Riehle-Colarusso, Tiffany J., MD, MSE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c465t-52e989c2ef61f06d79b6ad2fa6e500f36628c6deb09fdda98391a5aa3306a1b23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Biological and medical sciences</topic><topic>Body Mass Index</topic><topic>congenital heart defects</topic><topic>Diabetes, Gestational - epidemiology</topic><topic>Female</topic><topic>gestational diabetes</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Heart Defects, Congenital - epidemiology</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>obesity</topic><topic>Obesity - epidemiology</topic><topic>Obstetrics and Gynecology</topic><topic>Odds Ratio</topic><topic>Pregnancy</topic><topic>Pregnancy Complications - epidemiology</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gilboa, Suzanne M., PhD</creatorcontrib><creatorcontrib>Correa, Adolfo, MD, PhD</creatorcontrib><creatorcontrib>Botto, Lorenzo D., MD</creatorcontrib><creatorcontrib>Rasmussen, Sonja A., MD, MS</creatorcontrib><creatorcontrib>Waller, D. Kim, PhD</creatorcontrib><creatorcontrib>Hobbs, Charlotte A., MD, PhD</creatorcontrib><creatorcontrib>Cleves, Mario A., PhD</creatorcontrib><creatorcontrib>Riehle-Colarusso, Tiffany J., MD, MSE</creatorcontrib><creatorcontrib>National Birth Defects Prevention Study</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of obstetrics and gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gilboa, Suzanne M., PhD</au><au>Correa, Adolfo, MD, PhD</au><au>Botto, Lorenzo D., MD</au><au>Rasmussen, Sonja A., MD, MS</au><au>Waller, D. Kim, PhD</au><au>Hobbs, Charlotte A., MD, PhD</au><au>Cleves, Mario A., PhD</au><au>Riehle-Colarusso, Tiffany J., MD, MSE</au><aucorp>National Birth Defects Prevention Study</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between prepregnancy body mass index and congenital heart defects</atitle><jtitle>American journal of obstetrics and gynecology</jtitle><addtitle>Am J Obstet Gynecol</addtitle><date>2010</date><risdate>2010</risdate><volume>202</volume><issue>1</issue><spage>51.e1</spage><epage>51.e10</epage><pages>51.e1-51.e10</pages><issn>0002-9378</issn><eissn>1097-6868</eissn><coden>AJOGAH</coden><abstract>Objective The purpose of this study was to examine associations between prepregnancy body mass index (BMI) and congenital heart defects (CHDs). Study Design These analyses included case infants with CHDs (n = 6440) and liveborn control infants without birth defects (n = 5673) enrolled in the National Birth Defects Prevention Study (1997-2004). Results Adjusted odds ratios for all CHDs combined were 1.16 (95% confidence interval [CI], 1.05–1.29), 1.15 (95% CI, 1.00–1.32), and 1.31 (95% CI, 1.11–1.56) for overweight status, moderate obesity, and severe obesity, respectively. Phenotypes associated with elevated BMI (≥25.0 kg/m2 ) were conotruncal defects (tetralogy of Fallot), total anomalous pulmonary venous return, hypoplastic left heart syndrome, right ventricular outflow tract (RVOT) defects (pulmonary valve stenosis), and septal defects (secundum atrial septal defect). Conclusion These results corroborated those of previous studies and suggested new associations between obesity and conotruncal defects and RVOT defects.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>19796755</pmid><doi>10.1016/j.ajog.2009.08.005</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0002-9378 |
| ispartof | American journal of obstetrics and gynecology, 2010, Vol.202 (1), p.51.e1-51.e10 |
| issn | 0002-9378 1097-6868 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_734254054 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Biological and medical sciences Body Mass Index congenital heart defects Diabetes, Gestational - epidemiology Female gestational diabetes Gynecology. Andrology. Obstetrics Heart Defects, Congenital - epidemiology Humans Medical sciences obesity Obesity - epidemiology Obstetrics and Gynecology Odds Ratio Pregnancy Pregnancy Complications - epidemiology Risk Factors |
| title | Association between prepregnancy body mass index and congenital heart defects |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T18%3A15%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20between%20prepregnancy%20body%20mass%20index%20and%20congenital%20heart%20defects&rft.jtitle=American%20journal%20of%20obstetrics%20and%20gynecology&rft.au=Gilboa,%20Suzanne%20M.,%20PhD&rft.aucorp=National%20Birth%20Defects%20Prevention%20Study&rft.date=2010&rft.volume=202&rft.issue=1&rft.spage=51.e1&rft.epage=51.e10&rft.pages=51.e1-51.e10&rft.issn=0002-9378&rft.eissn=1097-6868&rft.coden=AJOGAH&rft_id=info:doi/10.1016/j.ajog.2009.08.005&rft_dat=%3Cproquest_cross%3E734254054%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=734254054&rft_id=info:pmid/19796755&rft_els_id=1_s2_0_S000293780900903X&rfr_iscdi=true |