Multiple molecular targets underlie the antidiabetic effect of Nigella sativa seed extract in skeletal muscle, adipocyte and liver cells

Aim:Nigella sativa (N. sativa) is a plant widely used in traditional medicine of North African countries. During the last decade, several studies have shown that extracts from the seeds of N. sativa have antidiabetic effects. Methods: Our group has recently demonstrated that N. sativa seed ethanol e...

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Veröffentlicht in:	Diabetes, obesity & metabolism obesity & metabolism, 2010-02, Vol.12 (2), p.148-157
Hauptverfasser:	Benhaddou-Andaloussi, A, Martineau, L.C, Vallerand, D, Haddad, Y, Afshar, A, Settaf, A, Haddad, P.S
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3-L1 adipocytes Adipocytes Adipocytes - drug effects Adipocytes - metabolism AKT protein Akt/protein kinase B AMP-activated protein kinase AMP-Activated Protein Kinases - drug effects AMP-Activated Protein Kinases - metabolism Animals Antidiabetics Blotting, Western C2C12 skeletal muscle cells Cells, Cultured Diabetes Diabetes mellitus H4IIE hepatocytes Hepatocytes Humans Hypoglycemic Agents - pharmacology Insulin intracellular signalling Kinases Liver Medicinal plants Metabolic syndrome Metabolism mitochondrial respiration Muscle, Skeletal - drug effects Muscle, Skeletal - metabolism Musculoskeletal system Nigella sativa Nigella sativa - chemistry Oxygen consumption peroxisome proliferator-activated receptor γ Peroxisome proliferator-activated receptors Plant Extracts - chemistry Plant Extracts - pharmacology PPAR gamma - metabolism Reporter gene Seeds Seeds - chemistry Signal Transduction Skeletal muscle type 2 diabetes mellitus uncoupling
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