Tissue-dependent effects of immunization with a nicotine conjugate vaccine on the distribution of nicotine in rats

Vaccination of rats against nicotine reduces nicotine distribution to brain even at nicotine doses greatly exceeding the estimated binding capacity of the available antibody. This observation suggests a differential effect by which vaccination reduces nicotine distribution to brain to a greater exte...

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Veröffentlicht in:	International immunopharmacology 2003-07, Vol.3 (7), p.957-970
Hauptverfasser:	Satoskar, S.D, Keyler, D.E, LeSage, M.G, Raphael, D.E, Ross, C.A, Pentel, P.R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies - blood Antibodies - metabolism Antibody Biological and medical sciences Brain - metabolism Fundamental and applied biological sciences. Psychology Fundamental immunology Immunization Immunobiology Male Modulation of the immune response (stimulation, suppression) Nicotine - blood Nicotine - immunology Nicotine - pharmacokinetics Nicotine dependence Pharmacokinetics Rats Rats, Sprague-Dawley Time Factors Tissue Distribution Vaccine Vaccines, Conjugate - administration & dosage Vaccines, Conjugate - immunology
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