Cyclin-Dependent Kinase 5 Phosphorylates Endothelial Nitric Oxide Synthase at Serine 116

Nitric oxide (NO) production in endothelial cells (EC) is regulated by multisite phosphorylation of specific serine and threonine residues in endothelial NO synthase (eNOS). Among these, eNOS-Ser116 is phosphorylated in the basal state, and its phosphorylation contributes to basal NO production. Her...

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Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 2010-02, Vol.55 (2), p.345-352
Hauptverfasser:	Cho, Du-Hyong, Seo, Jungwon, Park, Jung-Hyun, Jo, Chulman, Choi, Yoon Jung, Soh, Jae-Won, Jo, Inho
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Blotting, Western Cardiology. Vascular system Cattle Cells, Cultured Chemical and industrial products toxicology. Toxic occupational diseases Cyclin-Dependent Kinase 5 - genetics Cyclin-Dependent Kinase 5 - metabolism DNA, Complementary Endothelial Cells - cytology Endothelial Cells - drug effects Fluorescent Antibody Technique Gene Expression Regulation Medical sciences Metals and various inorganic compounds Nitric Oxide - metabolism Nitric Oxide Synthase Type III - drug effects Nitric Oxide Synthase Type III - genetics Nitric Oxide Synthase Type III - metabolism Phosphorylation - drug effects Phosphorylation - physiology Probability Protein Kinase Inhibitors - pharmacology Purines - pharmacology Reverse Transcriptase Polymerase Chain Reaction Serine - genetics Serine - metabolism Signal Transduction Toxicology Transfection
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