Prognostic implications of CpG island hypermethylator phenotype in colorectal cancers
CpG island methylator phenotype (CIMP) refers to a subset of colorectal cancers (CRCs) that are characterized by concordant hypermethylation of multiple CpG island loci. CIMP+ CRCs have peculiar clinicopathological features. However, controversy exists over prognostic implications of CIMP in CRCs. W...
Gespeichert in:
| Veröffentlicht in: | Virchows Archiv : an international journal of pathology 2009-12, Vol.455 (6), p.485-494 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 494 |
|---|---|
| container_issue | 6 |
| container_start_page | 485 |
| container_title | Virchows Archiv : an international journal of pathology |
| container_volume | 455 |
| creator | Kim, Jung Ho Shin, So Hyun Kwon, Hyeong Ju Cho, Nam Yun Kang, Gyeong Hoon |
| description | CpG island methylator phenotype (CIMP) refers to a subset of colorectal cancers (CRCs) that are characterized by concordant hypermethylation of multiple CpG island loci. CIMP+ CRCs have peculiar clinicopathological features. However, controversy exists over prognostic implications of CIMP in CRCs. We analyzed 320 cases of CRCs for their CIMP status using the MethyLight assay and determined clinicopathological features and prognostic implications of CIMP alone or in combination with microsatellite instability (MSI). With methylation of five or more markers among eight markers examined, CIMP+ tumors were significantly associated with female gender, proximal tumor location, poor differentiation, nodal metastasis, more advanced cancer,
BRAF
mutations, MSI, and poor prognosis (all
P
values |
| doi_str_mv | 10.1007/s00428-009-0857-0 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_734244216</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>734244216</sourcerecordid><originalsourceid>FETCH-LOGICAL-c499t-97e06545e077b1f6b933781cee0d634cdc53d1e811d47736a472cb8402be12a43</originalsourceid><addsrcrecordid>eNp9kU2LFDEQhoMo7uzoD_AiQZD10lqVz85xGXQVFvTgnkM6nd7J0t1pk57D_HuzzOCCoLkEkqeq3uQh5A3CRwTQnwqAYG0DYBpopW7gGdmg4KxhHPRzsgEjZKM46gtyWcoDAMMW1UtygcYgohEbcvcjp_s5lTV6GqdljN6tMc2FpoHulhsay-jmnu6PS8hTWPfH0a0p02Uf5rTWQxpn6tOYcvCrG6l3sw-5vCIvBjeW8Pq8b8ndl88_d1-b2-8333bXt40XxqyN0QGUFDKA1h0OqjOc6xZ9CNArLnzvJe8xtIi90JorJzTzXSuAdQGZE3xLrk59l5x-HUJZ7RSLD2PNHNKhWM0FE4KhquSH_5IoVMulFDXBlrz7C31IhzzXd1jGQGojgVUIT5DPqZQcBrvkOLl8tAj2UY49ybFVjn2UY6HWvD03PnRT6J8qzjYq8P4MuOLdOOT6m7H84VhdRipTOXbiSr2a70N-Svjv6b8B8rSl2w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>220579502</pqid></control><display><type>article</type><title>Prognostic implications of CpG island hypermethylator phenotype in colorectal cancers</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Kim, Jung Ho ; Shin, So Hyun ; Kwon, Hyeong Ju ; Cho, Nam Yun ; Kang, Gyeong Hoon</creator><creatorcontrib>Kim, Jung Ho ; Shin, So Hyun ; Kwon, Hyeong Ju ; Cho, Nam Yun ; Kang, Gyeong Hoon</creatorcontrib><description>CpG island methylator phenotype (CIMP) refers to a subset of colorectal cancers (CRCs) that are characterized by concordant hypermethylation of multiple CpG island loci. CIMP+ CRCs have peculiar clinicopathological features. However, controversy exists over prognostic implications of CIMP in CRCs. We analyzed 320 cases of CRCs for their CIMP status using the MethyLight assay and determined clinicopathological features and prognostic implications of CIMP alone or in combination with microsatellite instability (MSI). With methylation of five or more markers among eight markers examined, CIMP+ tumors were significantly associated with female gender, proximal tumor location, poor differentiation, nodal metastasis, more advanced cancer,
BRAF
mutations, MSI, and poor prognosis (all
P
values <0.05). Ogino’s combined eight-marker panel outperformed the Ogino and the Laird five-marker panels in detecting these features. Of the four molecular subtypes generated by the combination of CIMP and MSI status, the CIMP+/MSI− subtype showed the worst clinical outcome (
P
= 0.0003). However, poor prognosis of CIMP+/MSI− subtype was found to be attributed to
BRAF
mutation. In conclusion, the CIMP+/MSI− subtype tends to present with distinct clinicopathological and molecular features and shows the worst clinical outcome among the four molecular subtypes of CRCs.</description><identifier>ISSN: 0945-6317</identifier><identifier>EISSN: 1432-2307</identifier><identifier>DOI: 10.1007/s00428-009-0857-0</identifier><identifier>PMID: 19911194</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Colorectal cancer ; Colorectal Neoplasms - genetics ; Colorectal Neoplasms - pathology ; CpG Islands - genetics ; DNA Methylation ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Kaplan-Meier Estimate ; Male ; Medical sciences ; Medicine ; Medicine & Public Health ; Microsatellite Instability ; Middle Aged ; Mutation ; Original Article ; Pathology ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Prognosis ; Proto-Oncogene Proteins - genetics ; Proto-Oncogene Proteins B-raf - genetics ; Proto-Oncogene Proteins p21(ras) ; ras Proteins - genetics ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Tumors</subject><ispartof>Virchows Archiv : an international journal of pathology, 2009-12, Vol.455 (6), p.485-494</ispartof><rights>Springer-Verlag 2009</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-97e06545e077b1f6b933781cee0d634cdc53d1e811d47736a472cb8402be12a43</citedby><cites>FETCH-LOGICAL-c499t-97e06545e077b1f6b933781cee0d634cdc53d1e811d47736a472cb8402be12a43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00428-009-0857-0$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00428-009-0857-0$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22229569$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19911194$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Jung Ho</creatorcontrib><creatorcontrib>Shin, So Hyun</creatorcontrib><creatorcontrib>Kwon, Hyeong Ju</creatorcontrib><creatorcontrib>Cho, Nam Yun</creatorcontrib><creatorcontrib>Kang, Gyeong Hoon</creatorcontrib><title>Prognostic implications of CpG island hypermethylator phenotype in colorectal cancers</title><title>Virchows Archiv : an international journal of pathology</title><addtitle>Virchows Arch</addtitle><addtitle>Virchows Arch</addtitle><description>CpG island methylator phenotype (CIMP) refers to a subset of colorectal cancers (CRCs) that are characterized by concordant hypermethylation of multiple CpG island loci. CIMP+ CRCs have peculiar clinicopathological features. However, controversy exists over prognostic implications of CIMP in CRCs. We analyzed 320 cases of CRCs for their CIMP status using the MethyLight assay and determined clinicopathological features and prognostic implications of CIMP alone or in combination with microsatellite instability (MSI). With methylation of five or more markers among eight markers examined, CIMP+ tumors were significantly associated with female gender, proximal tumor location, poor differentiation, nodal metastasis, more advanced cancer,
BRAF
mutations, MSI, and poor prognosis (all
P
values <0.05). Ogino’s combined eight-marker panel outperformed the Ogino and the Laird five-marker panels in detecting these features. Of the four molecular subtypes generated by the combination of CIMP and MSI status, the CIMP+/MSI− subtype showed the worst clinical outcome (
P
= 0.0003). However, poor prognosis of CIMP+/MSI− subtype was found to be attributed to
BRAF
mutation. In conclusion, the CIMP+/MSI− subtype tends to present with distinct clinicopathological and molecular features and shows the worst clinical outcome among the four molecular subtypes of CRCs.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Colorectal cancer</subject><subject>Colorectal Neoplasms - genetics</subject><subject>Colorectal Neoplasms - pathology</subject><subject>CpG Islands - genetics</subject><subject>DNA Methylation</subject><subject>Female</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Kaplan-Meier Estimate</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Microsatellite Instability</subject><subject>Middle Aged</subject><subject>Mutation</subject><subject>Original Article</subject><subject>Pathology</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Prognosis</subject><subject>Proto-Oncogene Proteins - genetics</subject><subject>Proto-Oncogene Proteins B-raf - genetics</subject><subject>Proto-Oncogene Proteins p21(ras)</subject><subject>ras Proteins - genetics</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Tumors</subject><issn>0945-6317</issn><issn>1432-2307</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kU2LFDEQhoMo7uzoD_AiQZD10lqVz85xGXQVFvTgnkM6nd7J0t1pk57D_HuzzOCCoLkEkqeq3uQh5A3CRwTQnwqAYG0DYBpopW7gGdmg4KxhHPRzsgEjZKM46gtyWcoDAMMW1UtygcYgohEbcvcjp_s5lTV6GqdljN6tMc2FpoHulhsay-jmnu6PS8hTWPfH0a0p02Uf5rTWQxpn6tOYcvCrG6l3sw-5vCIvBjeW8Pq8b8ndl88_d1-b2-8333bXt40XxqyN0QGUFDKA1h0OqjOc6xZ9CNArLnzvJe8xtIi90JorJzTzXSuAdQGZE3xLrk59l5x-HUJZ7RSLD2PNHNKhWM0FE4KhquSH_5IoVMulFDXBlrz7C31IhzzXd1jGQGojgVUIT5DPqZQcBrvkOLl8tAj2UY49ybFVjn2UY6HWvD03PnRT6J8qzjYq8P4MuOLdOOT6m7H84VhdRipTOXbiSr2a70N-Svjv6b8B8rSl2w</recordid><startdate>20091201</startdate><enddate>20091201</enddate><creator>Kim, Jung Ho</creator><creator>Shin, So Hyun</creator><creator>Kwon, Hyeong Ju</creator><creator>Cho, Nam Yun</creator><creator>Kang, Gyeong Hoon</creator><general>Springer-Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7T7</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20091201</creationdate><title>Prognostic implications of CpG island hypermethylator phenotype in colorectal cancers</title><author>Kim, Jung Ho ; Shin, So Hyun ; Kwon, Hyeong Ju ; Cho, Nam Yun ; Kang, Gyeong Hoon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c499t-97e06545e077b1f6b933781cee0d634cdc53d1e811d47736a472cb8402be12a43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Colorectal cancer</topic><topic>Colorectal Neoplasms - genetics</topic><topic>Colorectal Neoplasms - pathology</topic><topic>CpG Islands - genetics</topic><topic>DNA Methylation</topic><topic>Female</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Kaplan-Meier Estimate</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Microsatellite Instability</topic><topic>Middle Aged</topic><topic>Mutation</topic><topic>Original Article</topic><topic>Pathology</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Prognosis</topic><topic>Proto-Oncogene Proteins - genetics</topic><topic>Proto-Oncogene Proteins B-raf - genetics</topic><topic>Proto-Oncogene Proteins p21(ras)</topic><topic>ras Proteins - genetics</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Jung Ho</creatorcontrib><creatorcontrib>Shin, So Hyun</creatorcontrib><creatorcontrib>Kwon, Hyeong Ju</creatorcontrib><creatorcontrib>Cho, Nam Yun</creatorcontrib><creatorcontrib>Kang, Gyeong Hoon</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Virchows Archiv : an international journal of pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Jung Ho</au><au>Shin, So Hyun</au><au>Kwon, Hyeong Ju</au><au>Cho, Nam Yun</au><au>Kang, Gyeong Hoon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic implications of CpG island hypermethylator phenotype in colorectal cancers</atitle><jtitle>Virchows Archiv : an international journal of pathology</jtitle><stitle>Virchows Arch</stitle><addtitle>Virchows Arch</addtitle><date>2009-12-01</date><risdate>2009</risdate><volume>455</volume><issue>6</issue><spage>485</spage><epage>494</epage><pages>485-494</pages><issn>0945-6317</issn><eissn>1432-2307</eissn><abstract>CpG island methylator phenotype (CIMP) refers to a subset of colorectal cancers (CRCs) that are characterized by concordant hypermethylation of multiple CpG island loci. CIMP+ CRCs have peculiar clinicopathological features. However, controversy exists over prognostic implications of CIMP in CRCs. We analyzed 320 cases of CRCs for their CIMP status using the MethyLight assay and determined clinicopathological features and prognostic implications of CIMP alone or in combination with microsatellite instability (MSI). With methylation of five or more markers among eight markers examined, CIMP+ tumors were significantly associated with female gender, proximal tumor location, poor differentiation, nodal metastasis, more advanced cancer,
BRAF
mutations, MSI, and poor prognosis (all
P
values <0.05). Ogino’s combined eight-marker panel outperformed the Ogino and the Laird five-marker panels in detecting these features. Of the four molecular subtypes generated by the combination of CIMP and MSI status, the CIMP+/MSI− subtype showed the worst clinical outcome (
P
= 0.0003). However, poor prognosis of CIMP+/MSI− subtype was found to be attributed to
BRAF
mutation. In conclusion, the CIMP+/MSI− subtype tends to present with distinct clinicopathological and molecular features and shows the worst clinical outcome among the four molecular subtypes of CRCs.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>19911194</pmid><doi>10.1007/s00428-009-0857-0</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0945-6317 |
| ispartof | Virchows Archiv : an international journal of pathology, 2009-12, Vol.455 (6), p.485-494 |
| issn | 0945-6317 1432-2307 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_734244216 |
| source | MEDLINE; SpringerNature Journals |
| subjects | Adult Aged Biological and medical sciences Colorectal cancer Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology CpG Islands - genetics DNA Methylation Female Gastroenterology. Liver. Pancreas. Abdomen Humans Investigative techniques, diagnostic techniques (general aspects) Kaplan-Meier Estimate Male Medical sciences Medicine Medicine & Public Health Microsatellite Instability Middle Aged Mutation Original Article Pathology Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Prognosis Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins B-raf - genetics Proto-Oncogene Proteins p21(ras) ras Proteins - genetics Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Tumors |
| title | Prognostic implications of CpG island hypermethylator phenotype in colorectal cancers |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-19T23%3A54%3A15IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Prognostic%20implications%20of%20CpG%20island%20hypermethylator%20phenotype%20in%20colorectal%20cancers&rft.jtitle=Virchows%20Archiv%20:%20an%20international%20journal%20of%20pathology&rft.au=Kim,%20Jung%20Ho&rft.date=2009-12-01&rft.volume=455&rft.issue=6&rft.spage=485&rft.epage=494&rft.pages=485-494&rft.issn=0945-6317&rft.eissn=1432-2307&rft_id=info:doi/10.1007/s00428-009-0857-0&rft_dat=%3Cproquest_cross%3E734244216%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=220579502&rft_id=info:pmid/19911194&rfr_iscdi=true |