Cystic lesions of the fetal kidney: Diagnosis and prediction of postnatal function by fetal urine biochemistry
Fetal urine was aspirated under ultrasound control from 21 large cystic renal masses in 18 pregnancies of 20 to 35 weeks gestation. None were associated with bladder or ureteric dilatation. At postnatal investigation, 12 kidneys were demonstrated to be hydronephrotic (5 with no or poor function) and...
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| Veröffentlicht in: | Journal of pediatric surgery 1992-11, Vol.27 (11), p.1451-1454 |
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| container_title | Journal of pediatric surgery |
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| creator | Nicolini, Umberto Vaughan, Janet I. Fisk, Nicholas M. Dhillon, Harjeet K. Rodeck, Charles H. |
| description | Fetal urine was aspirated under ultrasound control from 21 large cystic renal masses in 18 pregnancies of 20 to 35 weeks gestation. None were associated with bladder or ureteric dilatation. At postnatal investigation, 12 kidneys were demonstrated to be hydronephrotic (5 with no or poor function) and 9 multicystic. Urinary concentrations of sodium (Na
+), calcium (Ca
++), and phosphate (PO
4
−) were significantly higher in the multicystic group than in the hydronephrotic, whereas urea and creatinine levels were lower. Determination of urinary PO
4
− enabled differential diagnosis with no false-positive or false-negative cases. Among hydronephrotic kidneys, no biochemical parameter accurately predicted postnatal function, although creatinine was increased in all three nonfunctioning kidneys. In hydronephrotic kidneys, urinary Na
+ concentration increased with advancing gestational age (
r = .66;
P < .02), suggesting that the duration of hydronephrosis has a negative effect on renal function. |
| doi_str_mv | 10.1016/0022-3468(92)90198-G |
| format | Article |
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+), calcium (Ca
++), and phosphate (PO
4
−) were significantly higher in the multicystic group than in the hydronephrotic, whereas urea and creatinine levels were lower. Determination of urinary PO
4
− enabled differential diagnosis with no false-positive or false-negative cases. Among hydronephrotic kidneys, no biochemical parameter accurately predicted postnatal function, although creatinine was increased in all three nonfunctioning kidneys. In hydronephrotic kidneys, urinary Na
+ concentration increased with advancing gestational age (
r = .66;
P < .02), suggesting that the duration of hydronephrosis has a negative effect on renal function.</description><identifier>ISSN: 0022-3468</identifier><identifier>EISSN: 1531-5037</identifier><identifier>DOI: 10.1016/0022-3468(92)90198-G</identifier><identifier>PMID: 1479508</identifier><identifier>CODEN: JPDSA3</identifier><language>eng</language><publisher>Philadelphia, PA: Elsevier Inc</publisher><subject>Biological and medical sciences ; Calcium - urine ; Female ; Fetal Diseases - diagnosis ; Gestational Age ; Gynecology. Andrology. Obstetrics ; Humans ; Hydronephrosis - diagnosis ; Hydronephrosis - physiopathology ; Infant, Newborn ; Male ; Management. Prenatal diagnosis ; Medical sciences ; Phosphates - urine ; Polycystic Kidney Diseases - diagnosis ; Polycystic Kidney Diseases - diagnostic imaging ; Polycystic Kidney Diseases - physiopathology ; Pregnancy ; Pregnancy. Fetus. Placenta ; Prenatal Diagnosis ; Sodium - urine ; Ultrasonography, Prenatal</subject><ispartof>Journal of pediatric surgery, 1992-11, Vol.27 (11), p.1451-1454</ispartof><rights>1992</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-92169e04788252166b3b172581c743de53650cb77b3e4f18e1a78c088a1ffa43</citedby><cites>FETCH-LOGICAL-c386t-92169e04788252166b3b172581c743de53650cb77b3e4f18e1a78c088a1ffa43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0022-3468(92)90198-G$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4482405$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1479508$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nicolini, Umberto</creatorcontrib><creatorcontrib>Vaughan, Janet I.</creatorcontrib><creatorcontrib>Fisk, Nicholas M.</creatorcontrib><creatorcontrib>Dhillon, Harjeet K.</creatorcontrib><creatorcontrib>Rodeck, Charles H.</creatorcontrib><title>Cystic lesions of the fetal kidney: Diagnosis and prediction of postnatal function by fetal urine biochemistry</title><title>Journal of pediatric surgery</title><addtitle>J Pediatr Surg</addtitle><description>Fetal urine was aspirated under ultrasound control from 21 large cystic renal masses in 18 pregnancies of 20 to 35 weeks gestation. None were associated with bladder or ureteric dilatation. At postnatal investigation, 12 kidneys were demonstrated to be hydronephrotic (5 with no or poor function) and 9 multicystic. Urinary concentrations of sodium (Na
+), calcium (Ca
++), and phosphate (PO
4
−) were significantly higher in the multicystic group than in the hydronephrotic, whereas urea and creatinine levels were lower. Determination of urinary PO
4
− enabled differential diagnosis with no false-positive or false-negative cases. Among hydronephrotic kidneys, no biochemical parameter accurately predicted postnatal function, although creatinine was increased in all three nonfunctioning kidneys. In hydronephrotic kidneys, urinary Na
+ concentration increased with advancing gestational age (
r = .66;
P < .02), suggesting that the duration of hydronephrosis has a negative effect on renal function.</description><subject>Biological and medical sciences</subject><subject>Calcium - urine</subject><subject>Female</subject><subject>Fetal Diseases - diagnosis</subject><subject>Gestational Age</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Hydronephrosis - diagnosis</subject><subject>Hydronephrosis - physiopathology</subject><subject>Infant, Newborn</subject><subject>Male</subject><subject>Management. Prenatal diagnosis</subject><subject>Medical sciences</subject><subject>Phosphates - urine</subject><subject>Polycystic Kidney Diseases - diagnosis</subject><subject>Polycystic Kidney Diseases - diagnostic imaging</subject><subject>Polycystic Kidney Diseases - physiopathology</subject><subject>Pregnancy</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>Prenatal Diagnosis</subject><subject>Sodium - urine</subject><subject>Ultrasonography, Prenatal</subject><issn>0022-3468</issn><issn>1531-5037</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1v1DAQhi0EKtvCPwDJB4TgEPBXYqcHJLSFBakSl94txxlTQ9ZebAcp_x6HrMqN04xmnndsPQi9oOQdJbR7TwhjDRedetOztz2hvWoOj9COtpw2LeHyMdo9IE_RZc4_CKljQi_QBRWyb4naobBfcvEWT5B9DBlHh8s9YAfFTPinHwMs1_jGm-8hZp-xCSM-JRi9LRVf6VPMJZiVdnPYpsNyzs_JB8CDj_Yejj6XtDxDT5yZMjw_1yt09_nT3f5Lc_vt8HX_8baxXHWl6RnteiBCKsXa2ncDH6hkraJWCj5Cy7uW2EHKgYNwVAE1UlmilKHOGcGv0Ovt7CnFXzPkouvzFqbJBIhz1pILJhhTFRQbaFPMOYHTp-SPJi2aEr1a1qtCvSrUPdN_LetDjb0835-HI4z_QpvWun913ptszeSSCdbnB0wIxQRpK_Zhw6Cq-O0h6Ww9BFv9JrBFj9H__x9_AFHPmPk</recordid><startdate>19921101</startdate><enddate>19921101</enddate><creator>Nicolini, Umberto</creator><creator>Vaughan, Janet I.</creator><creator>Fisk, Nicholas M.</creator><creator>Dhillon, Harjeet K.</creator><creator>Rodeck, Charles H.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19921101</creationdate><title>Cystic lesions of the fetal kidney: Diagnosis and prediction of postnatal function by fetal urine biochemistry</title><author>Nicolini, Umberto ; Vaughan, Janet I. ; Fisk, Nicholas M. ; Dhillon, Harjeet K. ; Rodeck, Charles H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-92169e04788252166b3b172581c743de53650cb77b3e4f18e1a78c088a1ffa43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Biological and medical sciences</topic><topic>Calcium - urine</topic><topic>Female</topic><topic>Fetal Diseases - diagnosis</topic><topic>Gestational Age</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Hydronephrosis - diagnosis</topic><topic>Hydronephrosis - physiopathology</topic><topic>Infant, Newborn</topic><topic>Male</topic><topic>Management. Prenatal diagnosis</topic><topic>Medical sciences</topic><topic>Phosphates - urine</topic><topic>Polycystic Kidney Diseases - diagnosis</topic><topic>Polycystic Kidney Diseases - diagnostic imaging</topic><topic>Polycystic Kidney Diseases - physiopathology</topic><topic>Pregnancy</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>Prenatal Diagnosis</topic><topic>Sodium - urine</topic><topic>Ultrasonography, Prenatal</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nicolini, Umberto</creatorcontrib><creatorcontrib>Vaughan, Janet I.</creatorcontrib><creatorcontrib>Fisk, Nicholas M.</creatorcontrib><creatorcontrib>Dhillon, Harjeet K.</creatorcontrib><creatorcontrib>Rodeck, Charles H.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pediatric surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nicolini, Umberto</au><au>Vaughan, Janet I.</au><au>Fisk, Nicholas M.</au><au>Dhillon, Harjeet K.</au><au>Rodeck, Charles H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cystic lesions of the fetal kidney: Diagnosis and prediction of postnatal function by fetal urine biochemistry</atitle><jtitle>Journal of pediatric surgery</jtitle><addtitle>J Pediatr Surg</addtitle><date>1992-11-01</date><risdate>1992</risdate><volume>27</volume><issue>11</issue><spage>1451</spage><epage>1454</epage><pages>1451-1454</pages><issn>0022-3468</issn><eissn>1531-5037</eissn><coden>JPDSA3</coden><abstract>Fetal urine was aspirated under ultrasound control from 21 large cystic renal masses in 18 pregnancies of 20 to 35 weeks gestation. None were associated with bladder or ureteric dilatation. At postnatal investigation, 12 kidneys were demonstrated to be hydronephrotic (5 with no or poor function) and 9 multicystic. Urinary concentrations of sodium (Na
+), calcium (Ca
++), and phosphate (PO
4
−) were significantly higher in the multicystic group than in the hydronephrotic, whereas urea and creatinine levels were lower. Determination of urinary PO
4
− enabled differential diagnosis with no false-positive or false-negative cases. Among hydronephrotic kidneys, no biochemical parameter accurately predicted postnatal function, although creatinine was increased in all three nonfunctioning kidneys. In hydronephrotic kidneys, urinary Na
+ concentration increased with advancing gestational age (
r = .66;
P < .02), suggesting that the duration of hydronephrosis has a negative effect on renal function.</abstract><cop>Philadelphia, PA</cop><pub>Elsevier Inc</pub><pmid>1479508</pmid><doi>10.1016/0022-3468(92)90198-G</doi><tpages>4</tpages></addata></record> |
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| ispartof | Journal of pediatric surgery, 1992-11, Vol.27 (11), p.1451-1454 |
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| subjects | Biological and medical sciences Calcium - urine Female Fetal Diseases - diagnosis Gestational Age Gynecology. Andrology. Obstetrics Humans Hydronephrosis - diagnosis Hydronephrosis - physiopathology Infant, Newborn Male Management. Prenatal diagnosis Medical sciences Phosphates - urine Polycystic Kidney Diseases - diagnosis Polycystic Kidney Diseases - diagnostic imaging Polycystic Kidney Diseases - physiopathology Pregnancy Pregnancy. Fetus. Placenta Prenatal Diagnosis Sodium - urine Ultrasonography, Prenatal |
| title | Cystic lesions of the fetal kidney: Diagnosis and prediction of postnatal function by fetal urine biochemistry |
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