The Role of Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 in the p38/TNF-α Pathway of Systemic and Cutaneous Inflammation

Mitogen-activated protein kinase-activated protein kinase 2 (MK2) is a downstream molecule of p38, involved in the production of TNF-α, a key cytokine, and an established drug target for many inflammatory diseases. We investigated the role of MK2 in skin inflammation to determine its drug target pot...

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Veröffentlicht in:	Journal of investigative dermatology 2010-02, Vol.130 (2), p.481-491
Hauptverfasser:	Schottelius, Arndt J., Zügel, Ulrich, Döcke, Wolf-Dietrich, Zollner, Thomas M., Röse, Lars, Mengel, Anne, Buchmann, Bernd, Becker, Andreas, Grütz, Gerald, Naundorf, Sandra, Friedrich, Anke, Gaestel, Matthias, Asadullah, Khusru
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Dermatitis, Contact Dermatology Dinitrofluorobenzene - chemistry Female Granulocytes - cytology Homozygote Inflammation Intracellular Signaling Peptides and Proteins - metabolism Medical sciences Mice Mice, Inbred C57BL p38 Mitogen-Activated Protein Kinases - metabolism Protein-Serine-Threonine Kinases - metabolism Receptors, Antigen, T-Cell - metabolism Skin - enzymology Skin - pathology Tetradecanoylphorbol Acetate - pharmacology Tumor Necrosis Factor-alpha - metabolism
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