Leptin receptor 170 kDa (OB-R170) protein expression is reduced in obese human skeletal muscle: a potential mechanism of leptin resistance

To examine whether obesity-associated leptin resistance could be due to down-regulation of leptin receptors (OB-Rs) and/or up-regulation of suppressor of cytokine signalling 3 (SOCS3) and protein tyrosine phosphatase 1B (PTP1B) in skeletal muscle, which blunt janus kinase 2-dependent leptin signalli...

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Veröffentlicht in:	Experimental physiology 2010-01, Vol.95 (1), p.160-171
Hauptverfasser:	Fuentes, T., Ara, I., Guadalupe‐Grau, A., Larsen, S., Stallknecht, B., Olmedillas, H., Santana, A., Helge, J. W., Calbet, J. A. L., Guerra, B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Down-Regulation - physiology Humans Leptin - physiology Male Muscle, Skeletal - metabolism Obesity - genetics Obesity - metabolism Receptors, Leptin - antagonists & inhibitors Receptors, Leptin - biosynthesis Receptors, Leptin - genetics Signal Transduction - physiology Young Adult
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