Emerging clinical concerns in the ageing haemophilia patient
The availability of safe replacement clotting factor concentrates together with effective antiviral drugs to treat human immunodeficiency and hepatitis C viruses and the provision of care at designated haemophilia treatment centres have resulted in a new phenomenon in haemophilia management – the ag...
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| Veröffentlicht in: | Haemophilia : the official journal of the World Federation of Hemophilia 2009-11, Vol.15 (6), p.1197-1209 |
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| container_title | Haemophilia : the official journal of the World Federation of Hemophilia |
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| creator | KONKLE, B. A. KESSLER, C. ALEDORT, L. ANDERSEN, J. FOGARTY, P. KOUIDES, P. QUON, D. RAGNI, M. ZAKARIJA, A. EWENSTEIN, B. |
| description | The availability of safe replacement clotting factor concentrates together with effective antiviral drugs to treat human immunodeficiency and hepatitis C viruses and the provision of care at designated haemophilia treatment centres have resulted in a new phenomenon in haemophilia management – the ageing patient. Today, increasing numbers of persons with haemophilia (PWH) are middle‐aged and older, and they face the same age‐related health issues as the general population. The impact of these risks on PWH is unclear, however, and there is a paucity of information about how to manage comorbidities in this patient population. This review focuses on five comorbidities that uniquely affect older PWH: cardiovascular disease, liver disease, cancer, renal disease and joint disease. Available research is summarized and potential management approaches are suggested. |
| doi_str_mv | 10.1111/j.1365-2516.2009.02066.x |
| format | Article |
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This review focuses on five comorbidities that uniquely affect older PWH: cardiovascular disease, liver disease, cancer, renal disease and joint disease. 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| ispartof | Haemophilia : the official journal of the World Federation of Hemophilia, 2009-11, Vol.15 (6), p.1197-1209 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Aged ageing Blood Coagulation Factors - therapeutic use Cardiovascular Diseases - complications Cardiovascular Diseases - drug therapy Cardiovascular Diseases - epidemiology comorbidities Comorbidity Factor VIII - therapeutic use haemophilia Hemophilia A - complications Hemophilia A - drug therapy Hemophilia A - epidemiology Humans Joint Diseases - complications Joint Diseases - drug therapy Joint Diseases - epidemiology Kidney Failure, Chronic - complications Kidney Failure, Chronic - drug therapy Kidney Failure, Chronic - epidemiology Liver Diseases - complications Liver Diseases - drug therapy Liver Diseases - epidemiology Male Middle Aged Neoplasms - complications Neoplasms - drug therapy Neoplasms - epidemiology Practice Guidelines as Topic Risk Assessment |
| title | Emerging clinical concerns in the ageing haemophilia patient |
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