Porphyrin−Cyclodextrin Conjugates as a Nanosystem for Versatile Drug Delivery and Multimodal Cancer Therapy

The porphyrin−cyclodextrin conjugates were prepared and tested for selective and effective multifunctional drug delivery and therapy. The porphyrin receptor system combines efficient binding of the selected drug to the cyclodextrin cavity and photosensitizing properties of the porphyrin moiety with...

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Veröffentlicht in:	Journal of medicinal chemistry 2010-01, Vol.53 (1), p.128-138
Hauptverfasser:	KRALOVA, Jarmila, KEJIK, Zdeněk, BRIZA, Tomáš, POUCKOVA, Pavla, KRAL, Aleš, MARTASEK, Pavel, KRAL, Vladimir
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Antineoplastic Combined Chemotherapy Protocols - chemical synthesis Antineoplastic Combined Chemotherapy Protocols - chemistry Antineoplastic Combined Chemotherapy Protocols - pharmacology Biological and medical sciences Cell Death - drug effects Cell Line, Tumor Combined Modality Therapy Combined treatments (chemotherapy of immunotherapy associated with an other treatment) Cyclodextrins - chemical synthesis Cyclodextrins - chemistry Cyclodextrins - pharmacology Drug Delivery Systems Drug Screening Assays, Antitumor General aspects Humans Medical sciences Mice Nanotechnology Neoplasms - drug therapy Neoplasms - pathology Pharmacology. Drug treatments Photoradiation therapy and photosensitizing agent Porphyrins - chemical synthesis Porphyrins - chemistry Porphyrins - pharmacology Structure-Activity Relationship Treatment with physical agents Treatment. General aspects Tumors
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