Porphyrin−Cyclodextrin Conjugates as a Nanosystem for Versatile Drug Delivery and Multimodal Cancer Therapy
The porphyrin−cyclodextrin conjugates were prepared and tested for selective and effective multifunctional drug delivery and therapy. The porphyrin receptor system combines efficient binding of the selected drug to the cyclodextrin cavity and photosensitizing properties of the porphyrin moiety with...
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| Veröffentlicht in: | Journal of medicinal chemistry 2010-01, Vol.53 (1), p.128-138 |
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| container_end_page | 138 |
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| container_issue | 1 |
| container_start_page | 128 |
| container_title | Journal of medicinal chemistry |
| container_volume | 53 |
| creator | KRALOVA, Jarmila KEJIK, Zdeněk BRIZA, Tomáš POUCKOVA, Pavla KRAL, Aleš MARTASEK, Pavel KRAL, Vladimir |
| description | The porphyrin−cyclodextrin conjugates were prepared and tested for selective and effective multifunctional drug delivery and therapy. The porphyrin receptor system combines efficient binding of the selected drug to the cyclodextrin cavity and photosensitizing properties of the porphyrin moiety with high accumulation of the whole complex in cancer tissue. The combined effect of chemotherapy and photodynamic therapy is demonstrated by in vitro and in vivo studies. |
| doi_str_mv | 10.1021/jm9007278 |
| format | Article |
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The porphyrin receptor system combines efficient binding of the selected drug to the cyclodextrin cavity and photosensitizing properties of the porphyrin moiety with high accumulation of the whole complex in cancer tissue. The combined effect of chemotherapy and photodynamic therapy is demonstrated by in vitro and in vivo studies.</description><identifier>ISSN: 0022-2623</identifier><identifier>EISSN: 1520-4804</identifier><identifier>DOI: 10.1021/jm9007278</identifier><identifier>PMID: 19950899</identifier><identifier>CODEN: JMCMAR</identifier><language>eng</language><publisher>Columbus, OH: American Chemical Society</publisher><subject>Animals ; Antineoplastic agents ; Antineoplastic Combined Chemotherapy Protocols - chemical synthesis ; Antineoplastic Combined Chemotherapy Protocols - chemistry ; Antineoplastic Combined Chemotherapy Protocols - pharmacology ; Biological and medical sciences ; Cell Death - drug effects ; Cell Line, Tumor ; Combined Modality Therapy ; Combined treatments (chemotherapy of immunotherapy associated with an other treatment) ; Cyclodextrins - chemical synthesis ; Cyclodextrins - chemistry ; Cyclodextrins - pharmacology ; Drug Delivery Systems ; Drug Screening Assays, Antitumor ; General aspects ; Humans ; Medical sciences ; Mice ; Nanotechnology ; Neoplasms - drug therapy ; Neoplasms - pathology ; Pharmacology. Drug treatments ; Photoradiation therapy and photosensitizing agent ; Porphyrins - chemical synthesis ; Porphyrins - chemistry ; Porphyrins - pharmacology ; Structure-Activity Relationship ; Treatment with physical agents ; Treatment. General aspects ; Tumors</subject><ispartof>Journal of medicinal chemistry, 2010-01, Vol.53 (1), p.128-138</ispartof><rights>Copyright © 2009 American Chemical Society</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a344t-ecc349299599a3848b2fb3e036d08e694ba1c7653ce2b5a18ffd2e7d1bcd757a3</citedby><cites>FETCH-LOGICAL-a344t-ecc349299599a3848b2fb3e036d08e694ba1c7653ce2b5a18ffd2e7d1bcd757a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/jm9007278$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/jm9007278$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,2751,27055,27903,27904,56717,56767</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22361875$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19950899$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KRALOVA, Jarmila</creatorcontrib><creatorcontrib>KEJIK, Zdeněk</creatorcontrib><creatorcontrib>BRIZA, Tomáš</creatorcontrib><creatorcontrib>POUCKOVA, Pavla</creatorcontrib><creatorcontrib>KRAL, Aleš</creatorcontrib><creatorcontrib>MARTASEK, Pavel</creatorcontrib><creatorcontrib>KRAL, Vladimir</creatorcontrib><title>Porphyrin−Cyclodextrin Conjugates as a Nanosystem for Versatile Drug Delivery and Multimodal Cancer Therapy</title><title>Journal of medicinal chemistry</title><addtitle>J. Med. Chem</addtitle><description>The porphyrin−cyclodextrin conjugates were prepared and tested for selective and effective multifunctional drug delivery and therapy. The porphyrin receptor system combines efficient binding of the selected drug to the cyclodextrin cavity and photosensitizing properties of the porphyrin moiety with high accumulation of the whole complex in cancer tissue. The combined effect of chemotherapy and photodynamic therapy is demonstrated by in vitro and in vivo studies.</description><subject>Animals</subject><subject>Antineoplastic agents</subject><subject>Antineoplastic Combined Chemotherapy Protocols - chemical synthesis</subject><subject>Antineoplastic Combined Chemotherapy Protocols - chemistry</subject><subject>Antineoplastic Combined Chemotherapy Protocols - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Cell Death - drug effects</subject><subject>Cell Line, Tumor</subject><subject>Combined Modality Therapy</subject><subject>Combined treatments (chemotherapy of immunotherapy associated with an other treatment)</subject><subject>Cyclodextrins - chemical synthesis</subject><subject>Cyclodextrins - chemistry</subject><subject>Cyclodextrins - pharmacology</subject><subject>Drug Delivery Systems</subject><subject>Drug Screening Assays, Antitumor</subject><subject>General aspects</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Nanotechnology</subject><subject>Neoplasms - drug therapy</subject><subject>Neoplasms - pathology</subject><subject>Pharmacology. Drug treatments</subject><subject>Photoradiation therapy and photosensitizing agent</subject><subject>Porphyrins - chemical synthesis</subject><subject>Porphyrins - chemistry</subject><subject>Porphyrins - pharmacology</subject><subject>Structure-Activity Relationship</subject><subject>Treatment with physical agents</subject><subject>Treatment. General aspects</subject><subject>Tumors</subject><issn>0022-2623</issn><issn>1520-4804</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkElKxUAQhhtR9DksvID0RsRFtIdMvZQ4gtNC3YZKp6J5dNLP7kTMDVx7RE9i1KAboaAo-Pir6iNkm7MDzgQ_nDeKsUQk6RKZ8UiwIExZuExmjAkRiFjINbLu_ZwxJrmQq2SNKxWxVKkZaW6tWzwNrm4_3t6zQRtb4ms3jjSz7bx_hA49hbHoNbTWD77DhlbW0Qd0HrraID12_SM9RlO_oBsotCW96k1XN7YEQzNoNTp694QOFsMmWanAeNya-ga5Pz25y86Dy5uzi-zoMgAZhl2AWstQifFIpUCmYVqIqpDIZFyyFGMVFsB1EkdSoygi4GlVlQKTkhe6TKIE5AbZ-8ldOPvco-_ypvYajYEWbe_zRIZCsiiJRnL_h9TOeu-wyheubsANOWf5l9z8V-7I7kypfdFg-UdONkdgdwLAazCVG5-v_S8nhIx5-r104kD7fG57144y_ln4CUS6j3o</recordid><startdate>20100114</startdate><enddate>20100114</enddate><creator>KRALOVA, Jarmila</creator><creator>KEJIK, Zdeněk</creator><creator>BRIZA, Tomáš</creator><creator>POUCKOVA, Pavla</creator><creator>KRAL, Aleš</creator><creator>MARTASEK, Pavel</creator><creator>KRAL, Vladimir</creator><general>American Chemical Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20100114</creationdate><title>Porphyrin−Cyclodextrin Conjugates as a Nanosystem for Versatile Drug Delivery and Multimodal Cancer Therapy</title><author>KRALOVA, Jarmila ; KEJIK, Zdeněk ; BRIZA, Tomáš ; POUCKOVA, Pavla ; KRAL, Aleš ; MARTASEK, Pavel ; KRAL, Vladimir</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a344t-ecc349299599a3848b2fb3e036d08e694ba1c7653ce2b5a18ffd2e7d1bcd757a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Animals</topic><topic>Antineoplastic agents</topic><topic>Antineoplastic Combined Chemotherapy Protocols - chemical synthesis</topic><topic>Antineoplastic Combined Chemotherapy Protocols - chemistry</topic><topic>Antineoplastic Combined Chemotherapy Protocols - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Cell Death - drug effects</topic><topic>Cell Line, Tumor</topic><topic>Combined Modality Therapy</topic><topic>Combined treatments (chemotherapy of immunotherapy associated with an other treatment)</topic><topic>Cyclodextrins - chemical synthesis</topic><topic>Cyclodextrins - chemistry</topic><topic>Cyclodextrins - pharmacology</topic><topic>Drug Delivery Systems</topic><topic>Drug Screening Assays, Antitumor</topic><topic>General aspects</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Nanotechnology</topic><topic>Neoplasms - drug therapy</topic><topic>Neoplasms - pathology</topic><topic>Pharmacology. Drug treatments</topic><topic>Photoradiation therapy and photosensitizing agent</topic><topic>Porphyrins - chemical synthesis</topic><topic>Porphyrins - chemistry</topic><topic>Porphyrins - pharmacology</topic><topic>Structure-Activity Relationship</topic><topic>Treatment with physical agents</topic><topic>Treatment. 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Med. Chem</addtitle><date>2010-01-14</date><risdate>2010</risdate><volume>53</volume><issue>1</issue><spage>128</spage><epage>138</epage><pages>128-138</pages><issn>0022-2623</issn><eissn>1520-4804</eissn><coden>JMCMAR</coden><abstract>The porphyrin−cyclodextrin conjugates were prepared and tested for selective and effective multifunctional drug delivery and therapy. The porphyrin receptor system combines efficient binding of the selected drug to the cyclodextrin cavity and photosensitizing properties of the porphyrin moiety with high accumulation of the whole complex in cancer tissue. The combined effect of chemotherapy and photodynamic therapy is demonstrated by in vitro and in vivo studies.</abstract><cop>Columbus, OH</cop><pub>American Chemical Society</pub><pmid>19950899</pmid><doi>10.1021/jm9007278</doi><tpages>11</tpages></addata></record> |
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| ispartof | Journal of medicinal chemistry, 2010-01, Vol.53 (1), p.128-138 |
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| language | eng |
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| source | MEDLINE; American Chemical Society Journals |
| subjects | Animals Antineoplastic agents Antineoplastic Combined Chemotherapy Protocols - chemical synthesis Antineoplastic Combined Chemotherapy Protocols - chemistry Antineoplastic Combined Chemotherapy Protocols - pharmacology Biological and medical sciences Cell Death - drug effects Cell Line, Tumor Combined Modality Therapy Combined treatments (chemotherapy of immunotherapy associated with an other treatment) Cyclodextrins - chemical synthesis Cyclodextrins - chemistry Cyclodextrins - pharmacology Drug Delivery Systems Drug Screening Assays, Antitumor General aspects Humans Medical sciences Mice Nanotechnology Neoplasms - drug therapy Neoplasms - pathology Pharmacology. Drug treatments Photoradiation therapy and photosensitizing agent Porphyrins - chemical synthesis Porphyrins - chemistry Porphyrins - pharmacology Structure-Activity Relationship Treatment with physical agents Treatment. General aspects Tumors |
| title | Porphyrin−Cyclodextrin Conjugates as a Nanosystem for Versatile Drug Delivery and Multimodal Cancer Therapy |
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