Anetoderma in cutaneous marginal-zone B-cell lymphoma
Summary Anetoderma is a rare condition, consisting of well‐circumscribed areas of slack skin, in which dermal elastic fibres are destroyed or deficient. We present the case of a 45‐year‐old man with a 25‐year history of deep nodules and plaques gradually progressing to areas of anetoderma. Histologi...
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| Veröffentlicht in: | Clinical and experimental dermatology 2009-12, Vol.34 (8), p.e945-e948 |
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| container_issue | 8 |
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| container_title | Clinical and experimental dermatology |
| container_volume | 34 |
| creator | Zattra, E. Pigozzi, B. Bordignon, M. Marino, F. Chiarion-Sileni, V. Alaibac, M. |
| description | Summary
Anetoderma is a rare condition, consisting of well‐circumscribed areas of slack skin, in which dermal elastic fibres are destroyed or deficient. We present the case of a 45‐year‐old man with a 25‐year history of deep nodules and plaques gradually progressing to areas of anetoderma. Histological examination found an infiltrate composed of neoplastic cells with lymphoplasmocytoid morphology. The cells were positive for CD20, CD38 and CD138, and there was a monoclonal kappa light chain gene rearrangement of plasma cells. A diagnosis of cutaneous marginal‐zone B‐cell lymphoma was made. The pathogenesis of anetoderma remains unknown, but it is possible that cytokines or other soluble factors produced by the infiltrating lymphocytes have a role in this process. |
| doi_str_mv | 10.1111/j.1365-2230.2009.03593.x |
| format | Article |
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Anetoderma is a rare condition, consisting of well‐circumscribed areas of slack skin, in which dermal elastic fibres are destroyed or deficient. We present the case of a 45‐year‐old man with a 25‐year history of deep nodules and plaques gradually progressing to areas of anetoderma. Histological examination found an infiltrate composed of neoplastic cells with lymphoplasmocytoid morphology. The cells were positive for CD20, CD38 and CD138, and there was a monoclonal kappa light chain gene rearrangement of plasma cells. A diagnosis of cutaneous marginal‐zone B‐cell lymphoma was made. The pathogenesis of anetoderma remains unknown, but it is possible that cytokines or other soluble factors produced by the infiltrating lymphocytes have a role in this process.</description><identifier>ISSN: 0307-6938</identifier><identifier>EISSN: 1365-2230</identifier><identifier>DOI: 10.1111/j.1365-2230.2009.03593.x</identifier><identifier>PMID: 19778307</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Anetoderma - immunology ; Anetoderma - metabolism ; B-Lymphocytes - immunology ; B-Lymphocytes - metabolism ; Elastic Tissue - metabolism ; Humans ; Immunohistochemistry ; Lymphoma, B-Cell, Marginal Zone - immunology ; Lymphoma, B-Cell, Marginal Zone - metabolism ; Male ; Middle Aged ; Skin - metabolism</subject><ispartof>Clinical and experimental dermatology, 2009-12, Vol.34 (8), p.e945-e948</ispartof><rights>2009 The Author(s). Journal compilation © 2009 British Association of Dermatologists</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4063-233842ec8624f52ef45032b0fe6b60a40cc607bcc45976a461f1fd0e2acd22a3</citedby><cites>FETCH-LOGICAL-c4063-233842ec8624f52ef45032b0fe6b60a40cc607bcc45976a461f1fd0e2acd22a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19778307$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zattra, E.</creatorcontrib><creatorcontrib>Pigozzi, B.</creatorcontrib><creatorcontrib>Bordignon, M.</creatorcontrib><creatorcontrib>Marino, F.</creatorcontrib><creatorcontrib>Chiarion-Sileni, V.</creatorcontrib><creatorcontrib>Alaibac, M.</creatorcontrib><title>Anetoderma in cutaneous marginal-zone B-cell lymphoma</title><title>Clinical and experimental dermatology</title><addtitle>Clin Exp Dermatol</addtitle><description>Summary
Anetoderma is a rare condition, consisting of well‐circumscribed areas of slack skin, in which dermal elastic fibres are destroyed or deficient. We present the case of a 45‐year‐old man with a 25‐year history of deep nodules and plaques gradually progressing to areas of anetoderma. Histological examination found an infiltrate composed of neoplastic cells with lymphoplasmocytoid morphology. The cells were positive for CD20, CD38 and CD138, and there was a monoclonal kappa light chain gene rearrangement of plasma cells. A diagnosis of cutaneous marginal‐zone B‐cell lymphoma was made. The pathogenesis of anetoderma remains unknown, but it is possible that cytokines or other soluble factors produced by the infiltrating lymphocytes have a role in this process.</description><subject>Anetoderma - immunology</subject><subject>Anetoderma - metabolism</subject><subject>B-Lymphocytes - immunology</subject><subject>B-Lymphocytes - metabolism</subject><subject>Elastic Tissue - metabolism</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Lymphoma, B-Cell, Marginal Zone - immunology</subject><subject>Lymphoma, B-Cell, Marginal Zone - metabolism</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Skin - metabolism</subject><issn>0307-6938</issn><issn>1365-2230</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMtOwzAQRS0EoqXwCyg7VgnjR-xkwaItpSBVoEqVKrGxHMeBlDxKnIiWrychVdnijS3NPeOZg5CDwcPtud14mHLfJYSCRwBCD6gfUm93gobHwikaAgXh8pAGA3Rh7QYAUyz8czTAoRBBWxwif1yYuoxNlSsnLRzd1KowZWOdXFVvaaEy97ssjDNxtckyJ9vn2_cyV5foLFGZNVeHe4RWD7PV9NFdvMyfpuOFqxlw6hJKA0aMDjhhiU9MwnygJILE8IiDYqA1BxFpzfxQcMU4TnASgyFKx4QoOkI3fdttVX42xtYyT203SD-jFJS1izJM22TQJ3VVWluZRG6rtF1hLzHITpncyM6M7MzITpn8VSZ3LXp9-KSJchP_gQdHbeCuD3ylmdn_u7Gczu67V8u7PZ_a2uyOvKo-JBdU-HL9PJewXK4n4hXLKf0BILaH7w</recordid><startdate>200912</startdate><enddate>200912</enddate><creator>Zattra, E.</creator><creator>Pigozzi, B.</creator><creator>Bordignon, M.</creator><creator>Marino, F.</creator><creator>Chiarion-Sileni, V.</creator><creator>Alaibac, M.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200912</creationdate><title>Anetoderma in cutaneous marginal-zone B-cell lymphoma</title><author>Zattra, E. ; Pigozzi, B. ; Bordignon, M. ; Marino, F. ; Chiarion-Sileni, V. ; Alaibac, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4063-233842ec8624f52ef45032b0fe6b60a40cc607bcc45976a461f1fd0e2acd22a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Anetoderma - immunology</topic><topic>Anetoderma - metabolism</topic><topic>B-Lymphocytes - immunology</topic><topic>B-Lymphocytes - metabolism</topic><topic>Elastic Tissue - metabolism</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Lymphoma, B-Cell, Marginal Zone - immunology</topic><topic>Lymphoma, B-Cell, Marginal Zone - metabolism</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Skin - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zattra, E.</creatorcontrib><creatorcontrib>Pigozzi, B.</creatorcontrib><creatorcontrib>Bordignon, M.</creatorcontrib><creatorcontrib>Marino, F.</creatorcontrib><creatorcontrib>Chiarion-Sileni, V.</creatorcontrib><creatorcontrib>Alaibac, M.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zattra, E.</au><au>Pigozzi, B.</au><au>Bordignon, M.</au><au>Marino, F.</au><au>Chiarion-Sileni, V.</au><au>Alaibac, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Anetoderma in cutaneous marginal-zone B-cell lymphoma</atitle><jtitle>Clinical and experimental dermatology</jtitle><addtitle>Clin Exp Dermatol</addtitle><date>2009-12</date><risdate>2009</risdate><volume>34</volume><issue>8</issue><spage>e945</spage><epage>e948</epage><pages>e945-e948</pages><issn>0307-6938</issn><eissn>1365-2230</eissn><abstract>Summary
Anetoderma is a rare condition, consisting of well‐circumscribed areas of slack skin, in which dermal elastic fibres are destroyed or deficient. We present the case of a 45‐year‐old man with a 25‐year history of deep nodules and plaques gradually progressing to areas of anetoderma. Histological examination found an infiltrate composed of neoplastic cells with lymphoplasmocytoid morphology. The cells were positive for CD20, CD38 and CD138, and there was a monoclonal kappa light chain gene rearrangement of plasma cells. A diagnosis of cutaneous marginal‐zone B‐cell lymphoma was made. The pathogenesis of anetoderma remains unknown, but it is possible that cytokines or other soluble factors produced by the infiltrating lymphocytes have a role in this process.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>19778307</pmid><doi>10.1111/j.1365-2230.2009.03593.x</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0307-6938 |
| ispartof | Clinical and experimental dermatology, 2009-12, Vol.34 (8), p.e945-e948 |
| issn | 0307-6938 1365-2230 |
| language | eng |
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| source | MEDLINE; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Anetoderma - immunology Anetoderma - metabolism B-Lymphocytes - immunology B-Lymphocytes - metabolism Elastic Tissue - metabolism Humans Immunohistochemistry Lymphoma, B-Cell, Marginal Zone - immunology Lymphoma, B-Cell, Marginal Zone - metabolism Male Middle Aged Skin - metabolism |
| title | Anetoderma in cutaneous marginal-zone B-cell lymphoma |
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