The Exon 3-Deleted Growth Hormone Receptor Is Associated with Better Response to Pegvisomant Therapy in Acromegaly

Context: The deletion of exon 3 in the GH receptor (GHR) has been associated with a different biochemical picture and response to therapy in acromegaly. Objective: The aim of the study was to determine whether or not the GHR genotype influences the efficacy of pegvisomant treatment. Design and Setti...

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Veröffentlicht in:	The journal of clinical endocrinology and metabolism 2010-01, Vol.95 (1), p.222-229
Hauptverfasser:	Bernabeu, Ignacio, Alvarez-Escolá, Cristina, Quinteiro, Celsa, Lucas, Tomás, Puig-Domingo, Manel, Luque-Ramírez, Manuel, de Miguel-Novoa, Paz, Fernandez-Rodriguez, Eva, Halperin, Irene, Loidi, Lourdes, Casanueva, Felipe F, Marazuela, Mónica
Format:	Artikel
Sprache:	eng
Schlagworte:	Acromegaly Acromegaly - diagnosis Acromegaly - drug therapy Acromegaly - genetics Adult Aged Biological and medical sciences Cross-Sectional Studies Disease resistance Dose-Response Relationship, Drug Drug Resistance - drug effects Drug Resistance - genetics Endocrinopathies Exons Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Genotype Genotype & phenotype Genotypes Growth hormones Hormone Antagonists - therapeutic use Human Growth Hormone - administration & dosage Human Growth Hormone - analogs & derivatives Human Growth Hormone - therapeutic use Humans Hypothalamus. Hypophysis. Epiphysis (diseases) Insulin-like growth factor I Male Medical sciences Middle Aged Mutant Proteins - physiology Non tumoral diseases. Target tissue resistance. Benign neoplasms Patients Prognosis Receptors, Somatotropin - antagonists & inhibitors Receptors, Somatotropin - genetics Receptors, Somatotropin - physiology Regression analysis Retrospective Studies Sequence Deletion - physiology Somatostatin Treatment Outcome Vertebrates: anatomy and physiology, studies on body, several organs or systems Vertebrates: endocrinology Weight
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