A randomized, double-blind, placebo-controlled study to evaluate the efficacy in AD of liquid soap containing 12% ammonium lactate + 20% urea
Summary Atopic dermatitis (AD) is a common chronic skin disease, which mainly affects children. Xerosis is one of the most troublesome signs of the disease. The aim of this study was to evaluate the efficacy of liquid soap containing 12% ammonium lactate + 20% urea in patients with AD. In a randomiz...
Gespeichert in:
| Veröffentlicht in: | Clinical and experimental dermatology 2009-12, Vol.34 (8), p.e602-e604 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e604 |
|---|---|
| container_issue | 8 |
| container_start_page | e602 |
| container_title | Clinical and experimental dermatology |
| container_volume | 34 |
| creator | Amichai, B. Grunwald, M. H. |
| description | Summary
Atopic dermatitis (AD) is a common chronic skin disease, which mainly affects children. Xerosis is one of the most troublesome signs of the disease. The aim of this study was to evaluate the efficacy of liquid soap containing 12% ammonium lactate + 20% urea in patients with AD. In a randomized, double‐blind study, 36 patients (both male and female patients; age range 3–40 years) with mild to moderate AD were enrolled. Patients were divided randomly into two groups, in a ratio of 2 : 1 (active : placebo). The prescribed soap was used on a daily basis during a shower for 3 weeks. All patients continued all other systemic or topical medication but avoided any other soap or emollients. After 3 weeks of treatment, efficacy was assessed both by clinician and patient. There were significant improvements in scaling (P |
| doi_str_mv | 10.1111/j.1365-2230.2009.03273.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_734230237</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>734230237</sourcerecordid><originalsourceid>FETCH-LOGICAL-i3023-883802b192c79d11c6a9da7ab80ce5aaec7693214ee037cd35890926975eeae83</originalsourceid><addsrcrecordid>eNpFkc1u1DAUhS0EokPhFZA3FQtI8M8kThYsptNOi6hAIBBL68a-Ax6ceJrEMMMKiSfgFXkSHKYUS5Z9dc851vVHCOUs52k93-RclkUmhGS5YKzOmRRK5rs7ZHbbuEtmTDKVlbWsjsiDYdgwxiVXxX1yxOt5VbKinJFfC9pDZ0PrvqN9Rm2Ijces8a5L1daDwSZkJnRjH7xHS4cx2j0dA8Wv4COMSMfPSHG9dgbMnrqOLs5oWFPvrqNL8gBbOtnBda77RLk4odC2oXOxpSl9TAm_f_x8mrZgJzT2CA_JvTX4AR_dnMfkw-r8_fIyu3pz8XK5uMqcZEJmVSUrJhpeC6Nqy7kpobagoKmYwQIAjUqTCz5HZFIZK4uqZrUoa1UgAlbymDw55G77cB1xGHXrBoPeQ4chDlrJuZheUkn5-EYZmxat3vauhX6v__1iErw4CL45j_v_faYnWnqjJyh6gqInWvovLb3Ty_Oz6Zb82cHvhhF3t37ov-hSSVXoj68v9Lu3r9jp5UrqlfwDP4mYmg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>734230237</pqid></control><display><type>article</type><title>A randomized, double-blind, placebo-controlled study to evaluate the efficacy in AD of liquid soap containing 12% ammonium lactate + 20% urea</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Amichai, B. ; Grunwald, M. H.</creator><creatorcontrib>Amichai, B. ; Grunwald, M. H.</creatorcontrib><description>Summary
Atopic dermatitis (AD) is a common chronic skin disease, which mainly affects children. Xerosis is one of the most troublesome signs of the disease. The aim of this study was to evaluate the efficacy of liquid soap containing 12% ammonium lactate + 20% urea in patients with AD. In a randomized, double‐blind study, 36 patients (both male and female patients; age range 3–40 years) with mild to moderate AD were enrolled. Patients were divided randomly into two groups, in a ratio of 2 : 1 (active : placebo). The prescribed soap was used on a daily basis during a shower for 3 weeks. All patients continued all other systemic or topical medication but avoided any other soap or emollients. After 3 weeks of treatment, efficacy was assessed both by clinician and patient. There were significant improvements in scaling (P < 0.0001), skin dryness (P < 0.0001) and redness (P = 0.03) as rated by the investigator, and subjective patient assessment of itch also improved (P < 0.001) in the study group compared with the control group. The liquid soap was found to be effective in patients with AD, as use of this soap in patients with stable mild to moderate AD improved the parameters studied.</description><identifier>ISSN: 0307-6938</identifier><identifier>EISSN: 1365-2230</identifier><identifier>DOI: 10.1111/j.1365-2230.2009.03273.x</identifier><identifier>PMID: 19486056</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adolescent ; Adult ; Child ; Child, Preschool ; Dermatitis, Atopic - therapy ; Double-Blind Method ; Emollients - chemistry ; Emollients - therapeutic use ; Female ; Humans ; Lactates - therapeutic use ; Male ; Patient Compliance ; Quaternary Ammonium Compounds - adverse effects ; Quaternary Ammonium Compounds - chemistry ; Urea - therapeutic use ; Young Adult</subject><ispartof>Clinical and experimental dermatology, 2009-12, Vol.34 (8), p.e602-e604</ispartof><rights>2009 The Author(s). Journal compilation © 2009 British Association of Dermatologists</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19486056$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Amichai, B.</creatorcontrib><creatorcontrib>Grunwald, M. H.</creatorcontrib><title>A randomized, double-blind, placebo-controlled study to evaluate the efficacy in AD of liquid soap containing 12% ammonium lactate + 20% urea</title><title>Clinical and experimental dermatology</title><addtitle>Clin Exp Dermatol</addtitle><description>Summary
Atopic dermatitis (AD) is a common chronic skin disease, which mainly affects children. Xerosis is one of the most troublesome signs of the disease. The aim of this study was to evaluate the efficacy of liquid soap containing 12% ammonium lactate + 20% urea in patients with AD. In a randomized, double‐blind study, 36 patients (both male and female patients; age range 3–40 years) with mild to moderate AD were enrolled. Patients were divided randomly into two groups, in a ratio of 2 : 1 (active : placebo). The prescribed soap was used on a daily basis during a shower for 3 weeks. All patients continued all other systemic or topical medication but avoided any other soap or emollients. After 3 weeks of treatment, efficacy was assessed both by clinician and patient. There were significant improvements in scaling (P < 0.0001), skin dryness (P < 0.0001) and redness (P = 0.03) as rated by the investigator, and subjective patient assessment of itch also improved (P < 0.001) in the study group compared with the control group. The liquid soap was found to be effective in patients with AD, as use of this soap in patients with stable mild to moderate AD improved the parameters studied.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Dermatitis, Atopic - therapy</subject><subject>Double-Blind Method</subject><subject>Emollients - chemistry</subject><subject>Emollients - therapeutic use</subject><subject>Female</subject><subject>Humans</subject><subject>Lactates - therapeutic use</subject><subject>Male</subject><subject>Patient Compliance</subject><subject>Quaternary Ammonium Compounds - adverse effects</subject><subject>Quaternary Ammonium Compounds - chemistry</subject><subject>Urea - therapeutic use</subject><subject>Young Adult</subject><issn>0307-6938</issn><issn>1365-2230</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkc1u1DAUhS0EokPhFZA3FQtI8M8kThYsptNOi6hAIBBL68a-Ax6ceJrEMMMKiSfgFXkSHKYUS5Z9dc851vVHCOUs52k93-RclkUmhGS5YKzOmRRK5rs7ZHbbuEtmTDKVlbWsjsiDYdgwxiVXxX1yxOt5VbKinJFfC9pDZ0PrvqN9Rm2Ijces8a5L1daDwSZkJnRjH7xHS4cx2j0dA8Wv4COMSMfPSHG9dgbMnrqOLs5oWFPvrqNL8gBbOtnBda77RLk4odC2oXOxpSl9TAm_f_x8mrZgJzT2CA_JvTX4AR_dnMfkw-r8_fIyu3pz8XK5uMqcZEJmVSUrJhpeC6Nqy7kpobagoKmYwQIAjUqTCz5HZFIZK4uqZrUoa1UgAlbymDw55G77cB1xGHXrBoPeQ4chDlrJuZheUkn5-EYZmxat3vauhX6v__1iErw4CL45j_v_faYnWnqjJyh6gqInWvovLb3Ty_Oz6Zb82cHvhhF3t37ov-hSSVXoj68v9Lu3r9jp5UrqlfwDP4mYmg</recordid><startdate>200912</startdate><enddate>200912</enddate><creator>Amichai, B.</creator><creator>Grunwald, M. H.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200912</creationdate><title>A randomized, double-blind, placebo-controlled study to evaluate the efficacy in AD of liquid soap containing 12% ammonium lactate + 20% urea</title><author>Amichai, B. ; Grunwald, M. H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i3023-883802b192c79d11c6a9da7ab80ce5aaec7693214ee037cd35890926975eeae83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Dermatitis, Atopic - therapy</topic><topic>Double-Blind Method</topic><topic>Emollients - chemistry</topic><topic>Emollients - therapeutic use</topic><topic>Female</topic><topic>Humans</topic><topic>Lactates - therapeutic use</topic><topic>Male</topic><topic>Patient Compliance</topic><topic>Quaternary Ammonium Compounds - adverse effects</topic><topic>Quaternary Ammonium Compounds - chemistry</topic><topic>Urea - therapeutic use</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Amichai, B.</creatorcontrib><creatorcontrib>Grunwald, M. H.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Amichai, B.</au><au>Grunwald, M. H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A randomized, double-blind, placebo-controlled study to evaluate the efficacy in AD of liquid soap containing 12% ammonium lactate + 20% urea</atitle><jtitle>Clinical and experimental dermatology</jtitle><addtitle>Clin Exp Dermatol</addtitle><date>2009-12</date><risdate>2009</risdate><volume>34</volume><issue>8</issue><spage>e602</spage><epage>e604</epage><pages>e602-e604</pages><issn>0307-6938</issn><eissn>1365-2230</eissn><abstract>Summary
Atopic dermatitis (AD) is a common chronic skin disease, which mainly affects children. Xerosis is one of the most troublesome signs of the disease. The aim of this study was to evaluate the efficacy of liquid soap containing 12% ammonium lactate + 20% urea in patients with AD. In a randomized, double‐blind study, 36 patients (both male and female patients; age range 3–40 years) with mild to moderate AD were enrolled. Patients were divided randomly into two groups, in a ratio of 2 : 1 (active : placebo). The prescribed soap was used on a daily basis during a shower for 3 weeks. All patients continued all other systemic or topical medication but avoided any other soap or emollients. After 3 weeks of treatment, efficacy was assessed both by clinician and patient. There were significant improvements in scaling (P < 0.0001), skin dryness (P < 0.0001) and redness (P = 0.03) as rated by the investigator, and subjective patient assessment of itch also improved (P < 0.001) in the study group compared with the control group. The liquid soap was found to be effective in patients with AD, as use of this soap in patients with stable mild to moderate AD improved the parameters studied.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>19486056</pmid><doi>10.1111/j.1365-2230.2009.03273.x</doi><tpages>3</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0307-6938 |
| ispartof | Clinical and experimental dermatology, 2009-12, Vol.34 (8), p.e602-e604 |
| issn | 0307-6938 1365-2230 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_734230237 |
| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Alma/SFX Local Collection |
| subjects | Adolescent Adult Child Child, Preschool Dermatitis, Atopic - therapy Double-Blind Method Emollients - chemistry Emollients - therapeutic use Female Humans Lactates - therapeutic use Male Patient Compliance Quaternary Ammonium Compounds - adverse effects Quaternary Ammonium Compounds - chemistry Urea - therapeutic use Young Adult |
| title | A randomized, double-blind, placebo-controlled study to evaluate the efficacy in AD of liquid soap containing 12% ammonium lactate + 20% urea |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T07%3A13%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20randomized,%20double-blind,%20placebo-controlled%20study%20to%20evaluate%20the%20efficacy%20in%20AD%20of%20liquid%20soap%20containing%2012%25%20ammonium%20lactate%E2%80%83+%E2%80%8320%25%20urea&rft.jtitle=Clinical%20and%20experimental%20dermatology&rft.au=Amichai,%20B.&rft.date=2009-12&rft.volume=34&rft.issue=8&rft.spage=e602&rft.epage=e604&rft.pages=e602-e604&rft.issn=0307-6938&rft.eissn=1365-2230&rft_id=info:doi/10.1111/j.1365-2230.2009.03273.x&rft_dat=%3Cproquest_pubme%3E734230237%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=734230237&rft_id=info:pmid/19486056&rfr_iscdi=true |