Human papillomavirus type 16 found in primary transitional cell carcinoma of the Bartholin's gland and in a lymph node metastasis

We report a case of primary transitional cell carcinoma of the Bartholin's gland and its lymph node metastasis that contained HPV 16 sequences by polymerase chain reaction. The physical state of HPV 16 DNA in the primary cancer was investigated by Southern blot analysis which showed the presenc...

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Veröffentlicht in:Gynecologic oncology 1992, Vol.47 (2), p.263-266
Hauptverfasser: Scinicariello, Franco, Rady, Peter, Hannigan, Edward, Dinh, Tung V., Tyring, Stephen K.
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container_end_page 266
container_issue 2
container_start_page 263
container_title Gynecologic oncology
container_volume 47
creator Scinicariello, Franco
Rady, Peter
Hannigan, Edward
Dinh, Tung V.
Tyring, Stephen K.
description We report a case of primary transitional cell carcinoma of the Bartholin's gland and its lymph node metastasis that contained HPV 16 sequences by polymerase chain reaction. The physical state of HPV 16 DNA in the primary cancer was investigated by Southern blot analysis which showed the presence of the episomal form of viral DNA. Our findings of HPV 16 DNA in the transitional cell carcinoma of the Bartholin's gland and its metastasis would indicate that both tumors arose from a single clonal event, thus providing evidence that the HPV 16 may have an oncogenic potential in this rare malignancy even in the episomal state.
doi_str_mv 10.1016/0090-8258(92)90118-3
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subjects Adult
Bartholin's Glands - microbiology
Blotting, Southern
Carcinoma, Transitional Cell - microbiology
Carcinoma, Transitional Cell - secondary
Female
Humans
Lymphatic Metastasis
Papillomaviridae - isolation & purification
Polymerase Chain Reaction
Tumor Virus Infections - diagnosis
Vulvar Neoplasms - microbiology
title Human papillomavirus type 16 found in primary transitional cell carcinoma of the Bartholin's gland and in a lymph node metastasis
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