Effect of Iodoarachidonates on Thyroid FRTL-5 Cells Growth
Summary Excess iodide inhibits several thyroid parameters, by a putative organic iodocompound. Different iodolipids, including iodinated derivatives of arachidonic acid (IAs), are produced by rat, calf and pig thyroid. The action of two iodolactones, one bearing the iodine atom at the position 6 (IL...
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| Veröffentlicht in: | Hormone and metabolic research 1992-12, Vol.24 (12), p.558-561 |
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| creator | Pisarev, M. A. Bocanera, Laura V. Chester, H. A. Kleiman de Pisarev, Diana L. Juvenal, G. J. Pregliasco, Laura B. Krawiec, L. |
| description | Summary
Excess iodide inhibits several thyroid parameters, by a putative organic iodocompound. Different iodolipids, including iodinated derivatives of arachidonic acid (IAs), are produced by rat, calf and pig thyroid. The action of two iodolactones, one bearing the iodine atom at the position 6 (IL-d) and the other at position 14 (IL-w) on growth of FRTL-5 cells was studied. KI, IL-w and IL-d exert a dose-related inhibition on FRTL-5 cell profileration. The first two compounds caused inhibition at 1 μM while IL-d was effective at 10 μM. This inhibitory action of iodolactones (ILs) was not altered by 1 mM methyl-mercaptoimidazol (MMI), indicating that they exert their effect per se. The action of ILw on cell growth was reversible. The growth-stimulating effect of 10 uM forskolin was inhibited by IAs, showing that one possible site of action lies at the cAMP pathway. The present results give further support to our hypothesis about the role of IAs in thyroid growth autoregulation. |
| doi_str_mv | 10.1055/s-2007-1003389 |
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Excess iodide inhibits several thyroid parameters, by a putative organic iodocompound. Different iodolipids, including iodinated derivatives of arachidonic acid (IAs), are produced by rat, calf and pig thyroid. The action of two iodolactones, one bearing the iodine atom at the position 6 (IL-d) and the other at position 14 (IL-w) on growth of FRTL-5 cells was studied. KI, IL-w and IL-d exert a dose-related inhibition on FRTL-5 cell profileration. The first two compounds caused inhibition at 1 μM while IL-d was effective at 10 μM. This inhibitory action of iodolactones (ILs) was not altered by 1 mM methyl-mercaptoimidazol (MMI), indicating that they exert their effect per se. The action of ILw on cell growth was reversible. The growth-stimulating effect of 10 uM forskolin was inhibited by IAs, showing that one possible site of action lies at the cAMP pathway. The present results give further support to our hypothesis about the role of IAs in thyroid growth autoregulation.</description><identifier>ISSN: 0018-5043</identifier><identifier>EISSN: 1439-4286</identifier><identifier>DOI: 10.1055/s-2007-1003389</identifier><identifier>PMID: 1478612</identifier><identifier>CODEN: HMMRA2</identifier><language>eng</language><publisher>Stuttgart: Thieme</publisher><subject>Animals ; Arachidonic Acid - pharmacology ; Arachidonic Acids - pharmacology ; Biochemistry and metabolism ; Biological and medical sciences ; Cell Count ; Cell Division - drug effects ; Cell Line ; Central nervous system ; Colforsin - pharmacology ; DNA - metabolism ; Fundamental and applied biological sciences. Psychology ; Hydroxyeicosatetraenoic Acids - pharmacology ; Kinetics ; Originals Basic ; Rats ; Thyroid Gland - cytology ; Thyroid Gland - drug effects ; Thyrotropin - pharmacology ; Vertebrates: nervous system and sense organs</subject><ispartof>Hormone and metabolic research, 1992-12, Vol.24 (12), p.558-561</ispartof><rights>Georg Thieme Verlag, Stuttgart · New York</rights><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c454t-105f0d80501fc47a7177b26f6c4947b33c344af6ad7512b97d2cfc5490cd7a63</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-2007-1003389.pdf$$EPDF$$P50$$Gthieme$$H</linktopdf><link.rule.ids>314,780,784,3017,3018,27924,27925,54559</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4576221$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1478612$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pisarev, M. A.</creatorcontrib><creatorcontrib>Bocanera, Laura V.</creatorcontrib><creatorcontrib>Chester, H. A.</creatorcontrib><creatorcontrib>Kleiman de Pisarev, Diana L.</creatorcontrib><creatorcontrib>Juvenal, G. J.</creatorcontrib><creatorcontrib>Pregliasco, Laura B.</creatorcontrib><creatorcontrib>Krawiec, L.</creatorcontrib><title>Effect of Iodoarachidonates on Thyroid FRTL-5 Cells Growth</title><title>Hormone and metabolic research</title><addtitle>Horm Metab Res</addtitle><description>Summary
Excess iodide inhibits several thyroid parameters, by a putative organic iodocompound. Different iodolipids, including iodinated derivatives of arachidonic acid (IAs), are produced by rat, calf and pig thyroid. The action of two iodolactones, one bearing the iodine atom at the position 6 (IL-d) and the other at position 14 (IL-w) on growth of FRTL-5 cells was studied. KI, IL-w and IL-d exert a dose-related inhibition on FRTL-5 cell profileration. The first two compounds caused inhibition at 1 μM while IL-d was effective at 10 μM. This inhibitory action of iodolactones (ILs) was not altered by 1 mM methyl-mercaptoimidazol (MMI), indicating that they exert their effect per se. The action of ILw on cell growth was reversible. The growth-stimulating effect of 10 uM forskolin was inhibited by IAs, showing that one possible site of action lies at the cAMP pathway. The present results give further support to our hypothesis about the role of IAs in thyroid growth autoregulation.</description><subject>Animals</subject><subject>Arachidonic Acid - pharmacology</subject><subject>Arachidonic Acids - pharmacology</subject><subject>Biochemistry and metabolism</subject><subject>Biological and medical sciences</subject><subject>Cell Count</subject><subject>Cell Division - drug effects</subject><subject>Cell Line</subject><subject>Central nervous system</subject><subject>Colforsin - pharmacology</subject><subject>DNA - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hydroxyeicosatetraenoic Acids - pharmacology</subject><subject>Kinetics</subject><subject>Originals Basic</subject><subject>Rats</subject><subject>Thyroid Gland - cytology</subject><subject>Thyroid Gland - drug effects</subject><subject>Thyrotropin - pharmacology</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0018-5043</issn><issn>1439-4286</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEFLAzEQRoMotVav3oQ9iLetk2Sy2fUmpa2FgiC9hzSbsFvaTU22SP-9W7boSTwNw7z5ZniE3FMYUxDiOaYMQKYUgPO8uCBDirxIkeXZJRkC0DwVgPya3MS46VosKA7IgKLMM8qG5GXqnDVt4l2y8KXXQZuqLn2jWxsT3ySr6hh8XSazj9UyFcnEbrcxmQf_1Va35MrpbbR35zoiq9l0NXlLl-_zxeR1mRoU2HafCQdlDgKoMyi1pFKuWeYygwXKNeeGI2qX6VIKytaFLJlxRmABppQ64yPy1Mfug_882NiqXR1N94durD9EJTkyhhT-BWkmAIr8lDjuQRN8jME6tQ_1ToejoqBOUlVUJ6nqLLVbeDgnH9Y7W_7ivcVu_nie62j01gXdmDr-YChkxhjtsLTH2qq2O6s2_hCaztxfZ78BugaJtQ</recordid><startdate>19921201</startdate><enddate>19921201</enddate><creator>Pisarev, M. A.</creator><creator>Bocanera, Laura V.</creator><creator>Chester, H. A.</creator><creator>Kleiman de Pisarev, Diana L.</creator><creator>Juvenal, G. J.</creator><creator>Pregliasco, Laura B.</creator><creator>Krawiec, L.</creator><general>Thieme</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19921201</creationdate><title>Effect of Iodoarachidonates on Thyroid FRTL-5 Cells Growth</title><author>Pisarev, M. A. ; Bocanera, Laura V. ; Chester, H. A. ; Kleiman de Pisarev, Diana L. ; Juvenal, G. J. ; Pregliasco, Laura B. ; Krawiec, L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c454t-105f0d80501fc47a7177b26f6c4947b33c344af6ad7512b97d2cfc5490cd7a63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Animals</topic><topic>Arachidonic Acid - pharmacology</topic><topic>Arachidonic Acids - pharmacology</topic><topic>Biochemistry and metabolism</topic><topic>Biological and medical sciences</topic><topic>Cell Count</topic><topic>Cell Division - drug effects</topic><topic>Cell Line</topic><topic>Central nervous system</topic><topic>Colforsin - pharmacology</topic><topic>DNA - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hydroxyeicosatetraenoic Acids - pharmacology</topic><topic>Kinetics</topic><topic>Originals Basic</topic><topic>Rats</topic><topic>Thyroid Gland - cytology</topic><topic>Thyroid Gland - drug effects</topic><topic>Thyrotropin - pharmacology</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pisarev, M. A.</creatorcontrib><creatorcontrib>Bocanera, Laura V.</creatorcontrib><creatorcontrib>Chester, H. A.</creatorcontrib><creatorcontrib>Kleiman de Pisarev, Diana L.</creatorcontrib><creatorcontrib>Juvenal, G. J.</creatorcontrib><creatorcontrib>Pregliasco, Laura B.</creatorcontrib><creatorcontrib>Krawiec, L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Hormone and metabolic research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pisarev, M. A.</au><au>Bocanera, Laura V.</au><au>Chester, H. A.</au><au>Kleiman de Pisarev, Diana L.</au><au>Juvenal, G. J.</au><au>Pregliasco, Laura B.</au><au>Krawiec, L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Iodoarachidonates on Thyroid FRTL-5 Cells Growth</atitle><jtitle>Hormone and metabolic research</jtitle><addtitle>Horm Metab Res</addtitle><date>1992-12-01</date><risdate>1992</risdate><volume>24</volume><issue>12</issue><spage>558</spage><epage>561</epage><pages>558-561</pages><issn>0018-5043</issn><eissn>1439-4286</eissn><coden>HMMRA2</coden><abstract>Summary
Excess iodide inhibits several thyroid parameters, by a putative organic iodocompound. Different iodolipids, including iodinated derivatives of arachidonic acid (IAs), are produced by rat, calf and pig thyroid. The action of two iodolactones, one bearing the iodine atom at the position 6 (IL-d) and the other at position 14 (IL-w) on growth of FRTL-5 cells was studied. KI, IL-w and IL-d exert a dose-related inhibition on FRTL-5 cell profileration. The first two compounds caused inhibition at 1 μM while IL-d was effective at 10 μM. This inhibitory action of iodolactones (ILs) was not altered by 1 mM methyl-mercaptoimidazol (MMI), indicating that they exert their effect per se. The action of ILw on cell growth was reversible. The growth-stimulating effect of 10 uM forskolin was inhibited by IAs, showing that one possible site of action lies at the cAMP pathway. The present results give further support to our hypothesis about the role of IAs in thyroid growth autoregulation.</abstract><cop>Stuttgart</cop><cop>New York, NY</cop><pub>Thieme</pub><pmid>1478612</pmid><doi>10.1055/s-2007-1003389</doi><tpages>4</tpages></addata></record> |
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| subjects | Animals Arachidonic Acid - pharmacology Arachidonic Acids - pharmacology Biochemistry and metabolism Biological and medical sciences Cell Count Cell Division - drug effects Cell Line Central nervous system Colforsin - pharmacology DNA - metabolism Fundamental and applied biological sciences. Psychology Hydroxyeicosatetraenoic Acids - pharmacology Kinetics Originals Basic Rats Thyroid Gland - cytology Thyroid Gland - drug effects Thyrotropin - pharmacology Vertebrates: nervous system and sense organs |
| title | Effect of Iodoarachidonates on Thyroid FRTL-5 Cells Growth |
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