Severe telomere shortening in patients with paroxysmal nocturnal hemoglobinuria affects both GPI– and GPI+ hematopoiesis

A most distinctive feature of paroxysmal nocturnal hemoglobinuria (PNH) is that in each patient glycosylphosphatidylinositol-negative (GPI–) and GPI+ hematopoietic stem cells (HSCs) coexist, and both contribute to hematopoiesis. Telomere size correlates inversely with the cell division history of HS...

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Veröffentlicht in:	Blood 2003-07, Vol.102 (2), p.514-516
Hauptverfasser:	Karadimitris, Anastasios, Araten, David J., Luzzatto, Lucio, Notaro, Rosario
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Anemias. Hemoglobinopathies Biological and medical sciences Cell Division Clone Cells - chemistry Clone Cells - ultrastructure Diseases of red blood cells Female Glycosylphosphatidylinositols - deficiency Glycosylphosphatidylinositols - physiology Granulocytes - ultrastructure Hematologic and hematopoietic diseases Hematopoiesis - genetics Hematopoietic Stem Cells - chemistry Hematopoietic Stem Cells - ultrastructure Hemoglobinuria, Paroxysmal - genetics Humans Male Medical sciences Middle Aged Telomere - ultrastructure
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