The Biology of the (Pro)Renin Receptor

The (pro)renin receptor (PRR) binds renin and prorenin, its proenzyme inactive form. Receptor-bound prorenin becomes enzymatically active and binding then activates the MAP kinases ERK1/2 and p38 pathways, leading to upregulation of profibrotic and cyclooxygenase-2 genes independent of angiotensin I...

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Veröffentlicht in:	Journal of the American Society of Nephrology 2010, Vol.21 (1), p.18-23
Hauptverfasser:	NGUYEN, Genevieve, MULLER, Dominik N
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Disease Models, Animal Extracellular Signal-Regulated MAP Kinases - physiology Humans Hypertension - physiopathology Kidney Diseases - physiopathology Medical sciences Mice Mice, Knockout Nephrology. Urinary tract diseases Receptors, Cell Surface - genetics Receptors, Cell Surface - physiology Renin-Angiotensin System - physiology Signal Transduction - physiology
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