Plasma Phthalate Levels in Pubertal Gynecomastia
Several untoward health effects of phthalates, which are a group of industrial chemicals with many commercial uses including personal-care products and plastic materials, have been defined. The most commonly used, di-(2-ethylhexyl)-phthalate (DEHP), is known to have antiandrogenic or estrogenic effe...
Gespeichert in:
| Veröffentlicht in: | Pediatrics (Evanston) 2010-01, Vol.125 (1), p.e122-e129 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e129 |
|---|---|
| container_issue | 1 |
| container_start_page | e122 |
| container_title | Pediatrics (Evanston) |
| container_volume | 125 |
| creator | Durmaz, Erdem Ozmert, Elif N Erkekoglu, Pinar Giray, Belma Derman, Orhan Hincal, Filiz Yurdakok, Kadriye |
| description | Several untoward health effects of phthalates, which are a group of industrial chemicals with many commercial uses including personal-care products and plastic materials, have been defined. The most commonly used, di-(2-ethylhexyl)-phthalate (DEHP), is known to have antiandrogenic or estrogenic effects or both. Mono-(2-ethylhexyl)-phthalate (MEHP) is the main metabolite of DEHP. In this study, we aimed to determine the plasma DEHP and MEHP levels in pubertal gynecomastia cases.
The study group comprised 40 newly diagnosed pubertal gynecomastia cases who were admitted to Hacettepe University Ihsan Doğramaci Children's Hospital. The control group comprised 21 age-matched children without gynecomastia or other endocrinologic disorder. Plasma DEHP and MEHP levels were measured by using high-performance liquid chromatography. Serum hormone levels were determined in some pubertal gynecomastia cases according to the physician's evaluation.
Plasma DEHP and MEHP levels were found to be statistically significantly higher in the pubertal gynecomastia group compared with the control group (P < .001) (DEHP, 4.66 +/- 1.58 and 3.09 +/- 0.90 microg/mL, respectively [odds ratio: 2.77 (95% confidence interval: 1.48-5.21)]; MEHP, 3.19 +/- 1.41 and 1.37 +/- 0.36 microg/mL [odds ratio: 24.76 (95% confidence interval: 3.5-172.6)]). There was a statistically significant correlation between plasma DEHP and MEHP levels (r: 0.58; P < .001). In the pubertal gynecomastia group, no correlation could be determined between plasma DEHP and MEHP levels and any of the hormone levels.
DEHP, which has antiandrogenic or estrogenic effects, may be an etiologic factor in pubertal gynecomastia. These results may pioneer larger-scale studies on the etiologic role of DEHP in pubertal gynecomastia. |
| doi_str_mv | 10.1542/peds.2009-0724 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_734221470</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1939206391</sourcerecordid><originalsourceid>FETCH-LOGICAL-c512t-7d64247f6dffa16eb6a9d55088686ee8f2cf893d693e983e8ee28cc827553b0e3</originalsourceid><addsrcrecordid>eNpdkDFPwzAQhS0EoqWwMqKIhSnt-WwnzogqKEiV6ACz5SQXmippip2A-u9J1IIQ093wvaenj7FrDlOuJM52lPspAiQhxChP2JhDokOJsTplYwDBQwmgRuzC-w0ASBXjORv1AdCSJ2MGq8r62gardbu2lW0pWNInVT4ot8GqS8m1tgoW-y1lTW19W9pLdlbYytPV8U7Y2-PD6_wpXL4snuf3yzBTHNswziOJMi6ivCgsjyiNbJIrBVpHOiLSBWaFTkQeJYISLUgToc4y3Q9XIgUSE3Z36N255qMj35q69BlVld1S03kTC4nIZQw9efuP3DSd2_bjDKIWCrWMemh6gDLXeO-oMDtX1tbtDQczmDSDSTOYNIPJPnBzbO3SmvJf_EddD8wOwLp8X3-VjoaG0rauzPyfl6My3BBHFN8z7X43</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>228352846</pqid></control><display><type>article</type><title>Plasma Phthalate Levels in Pubertal Gynecomastia</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Durmaz, Erdem ; Ozmert, Elif N ; Erkekoglu, Pinar ; Giray, Belma ; Derman, Orhan ; Hincal, Filiz ; Yurdakok, Kadriye</creator><creatorcontrib>Durmaz, Erdem ; Ozmert, Elif N ; Erkekoglu, Pinar ; Giray, Belma ; Derman, Orhan ; Hincal, Filiz ; Yurdakok, Kadriye</creatorcontrib><description>Several untoward health effects of phthalates, which are a group of industrial chemicals with many commercial uses including personal-care products and plastic materials, have been defined. The most commonly used, di-(2-ethylhexyl)-phthalate (DEHP), is known to have antiandrogenic or estrogenic effects or both. Mono-(2-ethylhexyl)-phthalate (MEHP) is the main metabolite of DEHP. In this study, we aimed to determine the plasma DEHP and MEHP levels in pubertal gynecomastia cases.
The study group comprised 40 newly diagnosed pubertal gynecomastia cases who were admitted to Hacettepe University Ihsan Doğramaci Children's Hospital. The control group comprised 21 age-matched children without gynecomastia or other endocrinologic disorder. Plasma DEHP and MEHP levels were measured by using high-performance liquid chromatography. Serum hormone levels were determined in some pubertal gynecomastia cases according to the physician's evaluation.
Plasma DEHP and MEHP levels were found to be statistically significantly higher in the pubertal gynecomastia group compared with the control group (P < .001) (DEHP, 4.66 +/- 1.58 and 3.09 +/- 0.90 microg/mL, respectively [odds ratio: 2.77 (95% confidence interval: 1.48-5.21)]; MEHP, 3.19 +/- 1.41 and 1.37 +/- 0.36 microg/mL [odds ratio: 24.76 (95% confidence interval: 3.5-172.6)]). There was a statistically significant correlation between plasma DEHP and MEHP levels (r: 0.58; P < .001). In the pubertal gynecomastia group, no correlation could be determined between plasma DEHP and MEHP levels and any of the hormone levels.
DEHP, which has antiandrogenic or estrogenic effects, may be an etiologic factor in pubertal gynecomastia. These results may pioneer larger-scale studies on the etiologic role of DEHP in pubertal gynecomastia.</description><identifier>ISSN: 0031-4005</identifier><identifier>EISSN: 1098-4275</identifier><identifier>DOI: 10.1542/peds.2009-0724</identifier><identifier>PMID: 20008419</identifier><identifier>CODEN: PEDIAU</identifier><language>eng</language><publisher>United States: Am Acad Pediatrics</publisher><subject>Adolescent ; Blood Chemical Analysis ; Case-Control Studies ; Child ; Chromatography ; Diethylhexyl Phthalate - analogs & derivatives ; Diethylhexyl Phthalate - blood ; Diethylhexyl Phthalate - chemistry ; Environmental Exposure - adverse effects ; Gynecomastia - blood ; Gynecomastia - epidemiology ; Gynecomastia - etiology ; Hormones ; Humans ; Logistic Models ; Male ; Multivariate Analysis ; Pediatrics ; Phthalic Acids - blood ; Phthalic Acids - chemistry ; Plasma ; Probability ; Puberty ; Puberty - blood ; Puberty - physiology ; Radioimmunoassay ; Reference Values ; Risk Assessment ; Studies ; Tandem Mass Spectrometry ; Turkey</subject><ispartof>Pediatrics (Evanston), 2010-01, Vol.125 (1), p.e122-e129</ispartof><rights>Copyright American Academy of Pediatrics Jan 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c512t-7d64247f6dffa16eb6a9d55088686ee8f2cf893d693e983e8ee28cc827553b0e3</citedby><cites>FETCH-LOGICAL-c512t-7d64247f6dffa16eb6a9d55088686ee8f2cf893d693e983e8ee28cc827553b0e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27907,27908</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20008419$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Durmaz, Erdem</creatorcontrib><creatorcontrib>Ozmert, Elif N</creatorcontrib><creatorcontrib>Erkekoglu, Pinar</creatorcontrib><creatorcontrib>Giray, Belma</creatorcontrib><creatorcontrib>Derman, Orhan</creatorcontrib><creatorcontrib>Hincal, Filiz</creatorcontrib><creatorcontrib>Yurdakok, Kadriye</creatorcontrib><title>Plasma Phthalate Levels in Pubertal Gynecomastia</title><title>Pediatrics (Evanston)</title><addtitle>Pediatrics</addtitle><description>Several untoward health effects of phthalates, which are a group of industrial chemicals with many commercial uses including personal-care products and plastic materials, have been defined. The most commonly used, di-(2-ethylhexyl)-phthalate (DEHP), is known to have antiandrogenic or estrogenic effects or both. Mono-(2-ethylhexyl)-phthalate (MEHP) is the main metabolite of DEHP. In this study, we aimed to determine the plasma DEHP and MEHP levels in pubertal gynecomastia cases.
The study group comprised 40 newly diagnosed pubertal gynecomastia cases who were admitted to Hacettepe University Ihsan Doğramaci Children's Hospital. The control group comprised 21 age-matched children without gynecomastia or other endocrinologic disorder. Plasma DEHP and MEHP levels were measured by using high-performance liquid chromatography. Serum hormone levels were determined in some pubertal gynecomastia cases according to the physician's evaluation.
Plasma DEHP and MEHP levels were found to be statistically significantly higher in the pubertal gynecomastia group compared with the control group (P < .001) (DEHP, 4.66 +/- 1.58 and 3.09 +/- 0.90 microg/mL, respectively [odds ratio: 2.77 (95% confidence interval: 1.48-5.21)]; MEHP, 3.19 +/- 1.41 and 1.37 +/- 0.36 microg/mL [odds ratio: 24.76 (95% confidence interval: 3.5-172.6)]). There was a statistically significant correlation between plasma DEHP and MEHP levels (r: 0.58; P < .001). In the pubertal gynecomastia group, no correlation could be determined between plasma DEHP and MEHP levels and any of the hormone levels.
DEHP, which has antiandrogenic or estrogenic effects, may be an etiologic factor in pubertal gynecomastia. These results may pioneer larger-scale studies on the etiologic role of DEHP in pubertal gynecomastia.</description><subject>Adolescent</subject><subject>Blood Chemical Analysis</subject><subject>Case-Control Studies</subject><subject>Child</subject><subject>Chromatography</subject><subject>Diethylhexyl Phthalate - analogs & derivatives</subject><subject>Diethylhexyl Phthalate - blood</subject><subject>Diethylhexyl Phthalate - chemistry</subject><subject>Environmental Exposure - adverse effects</subject><subject>Gynecomastia - blood</subject><subject>Gynecomastia - epidemiology</subject><subject>Gynecomastia - etiology</subject><subject>Hormones</subject><subject>Humans</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Multivariate Analysis</subject><subject>Pediatrics</subject><subject>Phthalic Acids - blood</subject><subject>Phthalic Acids - chemistry</subject><subject>Plasma</subject><subject>Probability</subject><subject>Puberty</subject><subject>Puberty - blood</subject><subject>Puberty - physiology</subject><subject>Radioimmunoassay</subject><subject>Reference Values</subject><subject>Risk Assessment</subject><subject>Studies</subject><subject>Tandem Mass Spectrometry</subject><subject>Turkey</subject><issn>0031-4005</issn><issn>1098-4275</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkDFPwzAQhS0EoqWwMqKIhSnt-WwnzogqKEiV6ACz5SQXmippip2A-u9J1IIQ093wvaenj7FrDlOuJM52lPspAiQhxChP2JhDokOJsTplYwDBQwmgRuzC-w0ASBXjORv1AdCSJ2MGq8r62gardbu2lW0pWNInVT4ot8GqS8m1tgoW-y1lTW19W9pLdlbYytPV8U7Y2-PD6_wpXL4snuf3yzBTHNswziOJMi6ivCgsjyiNbJIrBVpHOiLSBWaFTkQeJYISLUgToc4y3Q9XIgUSE3Z36N255qMj35q69BlVld1S03kTC4nIZQw9efuP3DSd2_bjDKIWCrWMemh6gDLXeO-oMDtX1tbtDQczmDSDSTOYNIPJPnBzbO3SmvJf_EddD8wOwLp8X3-VjoaG0rauzPyfl6My3BBHFN8z7X43</recordid><startdate>20100101</startdate><enddate>20100101</enddate><creator>Durmaz, Erdem</creator><creator>Ozmert, Elif N</creator><creator>Erkekoglu, Pinar</creator><creator>Giray, Belma</creator><creator>Derman, Orhan</creator><creator>Hincal, Filiz</creator><creator>Yurdakok, Kadriye</creator><general>Am Acad Pediatrics</general><general>American Academy of Pediatrics</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>U9A</scope><scope>7X8</scope></search><sort><creationdate>20100101</creationdate><title>Plasma Phthalate Levels in Pubertal Gynecomastia</title><author>Durmaz, Erdem ; Ozmert, Elif N ; Erkekoglu, Pinar ; Giray, Belma ; Derman, Orhan ; Hincal, Filiz ; Yurdakok, Kadriye</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c512t-7d64247f6dffa16eb6a9d55088686ee8f2cf893d693e983e8ee28cc827553b0e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adolescent</topic><topic>Blood Chemical Analysis</topic><topic>Case-Control Studies</topic><topic>Child</topic><topic>Chromatography</topic><topic>Diethylhexyl Phthalate - analogs & derivatives</topic><topic>Diethylhexyl Phthalate - blood</topic><topic>Diethylhexyl Phthalate - chemistry</topic><topic>Environmental Exposure - adverse effects</topic><topic>Gynecomastia - blood</topic><topic>Gynecomastia - epidemiology</topic><topic>Gynecomastia - etiology</topic><topic>Hormones</topic><topic>Humans</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Multivariate Analysis</topic><topic>Pediatrics</topic><topic>Phthalic Acids - blood</topic><topic>Phthalic Acids - chemistry</topic><topic>Plasma</topic><topic>Probability</topic><topic>Puberty</topic><topic>Puberty - blood</topic><topic>Puberty - physiology</topic><topic>Radioimmunoassay</topic><topic>Reference Values</topic><topic>Risk Assessment</topic><topic>Studies</topic><topic>Tandem Mass Spectrometry</topic><topic>Turkey</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Durmaz, Erdem</creatorcontrib><creatorcontrib>Ozmert, Elif N</creatorcontrib><creatorcontrib>Erkekoglu, Pinar</creatorcontrib><creatorcontrib>Giray, Belma</creatorcontrib><creatorcontrib>Derman, Orhan</creatorcontrib><creatorcontrib>Hincal, Filiz</creatorcontrib><creatorcontrib>Yurdakok, Kadriye</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatrics (Evanston)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Durmaz, Erdem</au><au>Ozmert, Elif N</au><au>Erkekoglu, Pinar</au><au>Giray, Belma</au><au>Derman, Orhan</au><au>Hincal, Filiz</au><au>Yurdakok, Kadriye</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasma Phthalate Levels in Pubertal Gynecomastia</atitle><jtitle>Pediatrics (Evanston)</jtitle><addtitle>Pediatrics</addtitle><date>2010-01-01</date><risdate>2010</risdate><volume>125</volume><issue>1</issue><spage>e122</spage><epage>e129</epage><pages>e122-e129</pages><issn>0031-4005</issn><eissn>1098-4275</eissn><coden>PEDIAU</coden><abstract>Several untoward health effects of phthalates, which are a group of industrial chemicals with many commercial uses including personal-care products and plastic materials, have been defined. The most commonly used, di-(2-ethylhexyl)-phthalate (DEHP), is known to have antiandrogenic or estrogenic effects or both. Mono-(2-ethylhexyl)-phthalate (MEHP) is the main metabolite of DEHP. In this study, we aimed to determine the plasma DEHP and MEHP levels in pubertal gynecomastia cases.
The study group comprised 40 newly diagnosed pubertal gynecomastia cases who were admitted to Hacettepe University Ihsan Doğramaci Children's Hospital. The control group comprised 21 age-matched children without gynecomastia or other endocrinologic disorder. Plasma DEHP and MEHP levels were measured by using high-performance liquid chromatography. Serum hormone levels were determined in some pubertal gynecomastia cases according to the physician's evaluation.
Plasma DEHP and MEHP levels were found to be statistically significantly higher in the pubertal gynecomastia group compared with the control group (P < .001) (DEHP, 4.66 +/- 1.58 and 3.09 +/- 0.90 microg/mL, respectively [odds ratio: 2.77 (95% confidence interval: 1.48-5.21)]; MEHP, 3.19 +/- 1.41 and 1.37 +/- 0.36 microg/mL [odds ratio: 24.76 (95% confidence interval: 3.5-172.6)]). There was a statistically significant correlation between plasma DEHP and MEHP levels (r: 0.58; P < .001). In the pubertal gynecomastia group, no correlation could be determined between plasma DEHP and MEHP levels and any of the hormone levels.
DEHP, which has antiandrogenic or estrogenic effects, may be an etiologic factor in pubertal gynecomastia. These results may pioneer larger-scale studies on the etiologic role of DEHP in pubertal gynecomastia.</abstract><cop>United States</cop><pub>Am Acad Pediatrics</pub><pmid>20008419</pmid><doi>10.1542/peds.2009-0724</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0031-4005 |
| ispartof | Pediatrics (Evanston), 2010-01, Vol.125 (1), p.e122-e129 |
| issn | 0031-4005 1098-4275 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_734221470 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adolescent Blood Chemical Analysis Case-Control Studies Child Chromatography Diethylhexyl Phthalate - analogs & derivatives Diethylhexyl Phthalate - blood Diethylhexyl Phthalate - chemistry Environmental Exposure - adverse effects Gynecomastia - blood Gynecomastia - epidemiology Gynecomastia - etiology Hormones Humans Logistic Models Male Multivariate Analysis Pediatrics Phthalic Acids - blood Phthalic Acids - chemistry Plasma Probability Puberty Puberty - blood Puberty - physiology Radioimmunoassay Reference Values Risk Assessment Studies Tandem Mass Spectrometry Turkey |
| title | Plasma Phthalate Levels in Pubertal Gynecomastia |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-16T14%3A07%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Plasma%20Phthalate%20Levels%20in%20Pubertal%20Gynecomastia&rft.jtitle=Pediatrics%20(Evanston)&rft.au=Durmaz,%20Erdem&rft.date=2010-01-01&rft.volume=125&rft.issue=1&rft.spage=e122&rft.epage=e129&rft.pages=e122-e129&rft.issn=0031-4005&rft.eissn=1098-4275&rft.coden=PEDIAU&rft_id=info:doi/10.1542/peds.2009-0724&rft_dat=%3Cproquest_cross%3E1939206391%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=228352846&rft_id=info:pmid/20008419&rfr_iscdi=true |