Adrenomedullin is increased in alveolar macrophages and released from the lungs into the circulation in severe heart failure

Adrenomedullin (AM) is a potent vasorelaxing peptide with natriuretic, diuretic, and growth inhibitory properties. Plasma concentrations and myocardial AM expression are increased in heart failure (HF). Since AM and AM binding sites are abundantly expressed in the lungs, we investigated to what exte...

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Veröffentlicht in:	Basic research in cardiology 2010, Vol.105 (1), p.89-98
Hauptverfasser:	Øie, Erik, Ahmed, Mohammed Shakil, Ueland, Thor, Sikkeland, Liv Ingunn Bjoner, Dahl, Christen P., Hagelin, Else Marie Valbjørn, von Lueder, Thomas, Edvardsen, Thor, Andreassen, Arne K., Gullestad, Lars, Aukrust, Pål, Yndestad, Arne, Vinge, Leif Erik, Attramadal, Håvard
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenomedullin - metabolism Animals Binding Sites Blood Pressure Calcitonin Receptor-Like Protein Cardiology Gene Expression Heart Failure - immunology Heart Failure - metabolism Heart Failure - physiopathology Humans Immunohistochemistry Intracellular Signaling Peptides and Proteins - metabolism Lung - metabolism Lung - pathology Macrophages, Alveolar - metabolism Male Medicine Medicine & Public Health Membrane Proteins - metabolism Myocardial Infarction - metabolism Myocardial Infarction - physiopathology Myocardium - pathology Organ Size Original Contribution Rats Rats, Wistar Receptor Activity-Modifying Protein 2 Receptor Activity-Modifying Protein 3 Receptor Activity-Modifying Proteins Receptors, Adrenomedullin Receptors, Calcitonin - metabolism Receptors, Peptide - metabolism RNA, Messenger - metabolism Systole Ventricular Function, Left
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Zusammenfassung:	Adrenomedullin (AM) is a potent vasorelaxing peptide with natriuretic, diuretic, and growth inhibitory properties. Plasma concentrations and myocardial AM expression are increased in heart failure (HF). Since AM and AM binding sites are abundantly expressed in the lungs, we investigated to what extent pulmonary AM and AM receptor subtypes [CRLR/RAMP2 (AM 1 ) and CRLR/RAMP3 (AM 2 )] are changed in HF and whether the lungs contribute to the increased plasma concentrations of AM reported in HF. Pulmonary AM mRNA and protein expression were increased by 2.8- and 2.6-fold, respectively, whereas mRNA expression of RAMP2 and CRLR was decreased in rats with HF 7 days after induction of MI compared to sham-operated rats ( P
ISSN:	0300-8428 1435-1803
DOI:	10.1007/s00395-009-0070-y