Central Adiposity as a Major Risk Factor of Ovarian Cancer
The identification of risk factors for ovarian cancer is crucial in prevention of the disease. This pathology is the leading cause of death from gynecological malignancies. The aim of this study was to evaluate the role of factors influencing hormonal levels such as body mass index (BMI), BMI at age...
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| Veröffentlicht in: | Anticancer research 2009-12, Vol.29 (12), p.5229-5234 |
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| container_title | Anticancer research |
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| creator | Delort, Laetitia Kwiatkowski, Fabrice Chalabi, Nassera Satih, Samir Bignon, Yves-Jean Bernard-Gallon, Dominique J |
| description | The identification of risk factors for ovarian cancer is crucial in prevention of the disease. This pathology is the leading
cause of death from gynecological malignancies. The aim of this study was to evaluate the role of factors influencing hormonal
levels such as body mass index (BMI), BMI at age 20, waist-to-hip ratio (WHR), oral contraceptive (OC) use, and risk of ovarian
cancer. A case-control study was conducted in women who developed ovarian cancer. Logistic regression was used to calculate
the odds ratio (OR) and 95% confidence interval (95% CI). While no association was found between BMI, BMI at age 20 and risk
of ovarian cancer, high WHR increased the risk with ORs of 2.93 and 8.58 (p0.85) versus the lowest (WHR |
| format | Article |
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cause of death from gynecological malignancies. The aim of this study was to evaluate the role of factors influencing hormonal
levels such as body mass index (BMI), BMI at age 20, waist-to-hip ratio (WHR), oral contraceptive (OC) use, and risk of ovarian
cancer. A case-control study was conducted in women who developed ovarian cancer. Logistic regression was used to calculate
the odds ratio (OR) and 95% confidence interval (95% CI). While no association was found between BMI, BMI at age 20 and risk
of ovarian cancer, high WHR increased the risk with ORs of 2.93 and 8.58 (p<10 â6 ) for the highest categories (WHR=0.801-0.85 and WHR>0.85) versus the lowest (WHR<0.8). Central adiposity is a key factor
in ovarian cancer and suggests the involvement of androgen conversion in adipose tissue.</description><identifier>ISSN: 0250-7005</identifier><identifier>EISSN: 1791-7530</identifier><identifier>PMID: 20044641</identifier><language>eng</language><publisher>Greece: International Institute of Anticancer Research</publisher><subject>Adipose Tissue - physiopathology ; Adiposity - physiology ; Adult ; Aged ; Aged, 80 and over ; Case-Control Studies ; Female ; Follow-Up Studies ; Humans ; Middle Aged ; Obesity - complications ; Ovarian Neoplasms - complications ; Ovarian Neoplasms - physiopathology ; Risk Factors ; Waist-Hip Ratio</subject><ispartof>Anticancer research, 2009-12, Vol.29 (12), p.5229-5234</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20044641$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Delort, Laetitia</creatorcontrib><creatorcontrib>Kwiatkowski, Fabrice</creatorcontrib><creatorcontrib>Chalabi, Nassera</creatorcontrib><creatorcontrib>Satih, Samir</creatorcontrib><creatorcontrib>Bignon, Yves-Jean</creatorcontrib><creatorcontrib>Bernard-Gallon, Dominique J</creatorcontrib><title>Central Adiposity as a Major Risk Factor of Ovarian Cancer</title><title>Anticancer research</title><addtitle>Anticancer Res</addtitle><description>The identification of risk factors for ovarian cancer is crucial in prevention of the disease. This pathology is the leading
cause of death from gynecological malignancies. The aim of this study was to evaluate the role of factors influencing hormonal
levels such as body mass index (BMI), BMI at age 20, waist-to-hip ratio (WHR), oral contraceptive (OC) use, and risk of ovarian
cancer. A case-control study was conducted in women who developed ovarian cancer. Logistic regression was used to calculate
the odds ratio (OR) and 95% confidence interval (95% CI). While no association was found between BMI, BMI at age 20 and risk
of ovarian cancer, high WHR increased the risk with ORs of 2.93 and 8.58 (p<10 â6 ) for the highest categories (WHR=0.801-0.85 and WHR>0.85) versus the lowest (WHR<0.8). Central adiposity is a key factor
in ovarian cancer and suggests the involvement of androgen conversion in adipose tissue.</description><subject>Adipose Tissue - physiopathology</subject><subject>Adiposity - physiology</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Case-Control Studies</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>Obesity - complications</subject><subject>Ovarian Neoplasms - complications</subject><subject>Ovarian Neoplasms - physiopathology</subject><subject>Risk Factors</subject><subject>Waist-Hip Ratio</subject><issn>0250-7005</issn><issn>1791-7530</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1z8tKAzEYBeAgiq3VV5CsdDWQexp3ZbAqVAqi6_Ank7Gpc6nJVOnbO9C6OmfxceCcoSnVhhZacnKOpoRJUmhC5ARd5bwlRCkz55dowggRQgk6RQ9l6IYEDV5UcdfnOBwwZAz4FbZ9wm8xf-El-GHsfY3XP5AidLiEzod0jS5qaHK4OeUMfSwf38vnYrV-eikXq2LDBB2KuibEg2GCGS1kTaWWiinnAq28VyC8Y8JLJxXRhpMKauqc4NRUNdMuKMpn6P64u0v99z7kwbYx-9A00IV-n63mgtG5mptR3p7k3rWhsrsUW0gH-393BHdHsImfm9-Ygs0tNM3IuYXEjKXMSsYM_wOcUl0R</recordid><startdate>20091201</startdate><enddate>20091201</enddate><creator>Delort, Laetitia</creator><creator>Kwiatkowski, Fabrice</creator><creator>Chalabi, Nassera</creator><creator>Satih, Samir</creator><creator>Bignon, Yves-Jean</creator><creator>Bernard-Gallon, Dominique J</creator><general>International Institute of Anticancer Research</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20091201</creationdate><title>Central Adiposity as a Major Risk Factor of Ovarian Cancer</title><author>Delort, Laetitia ; Kwiatkowski, Fabrice ; Chalabi, Nassera ; Satih, Samir ; Bignon, Yves-Jean ; Bernard-Gallon, Dominique J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h241t-ff00ca92429745f1575626bbe1dcc6a4cb24c5b5607930daf1bb4319df27be613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adipose Tissue - physiopathology</topic><topic>Adiposity - physiology</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Case-Control Studies</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Middle Aged</topic><topic>Obesity - complications</topic><topic>Ovarian Neoplasms - complications</topic><topic>Ovarian Neoplasms - physiopathology</topic><topic>Risk Factors</topic><topic>Waist-Hip Ratio</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Delort, Laetitia</creatorcontrib><creatorcontrib>Kwiatkowski, Fabrice</creatorcontrib><creatorcontrib>Chalabi, Nassera</creatorcontrib><creatorcontrib>Satih, Samir</creatorcontrib><creatorcontrib>Bignon, Yves-Jean</creatorcontrib><creatorcontrib>Bernard-Gallon, Dominique J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Anticancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Delort, Laetitia</au><au>Kwiatkowski, Fabrice</au><au>Chalabi, Nassera</au><au>Satih, Samir</au><au>Bignon, Yves-Jean</au><au>Bernard-Gallon, Dominique J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Central Adiposity as a Major Risk Factor of Ovarian Cancer</atitle><jtitle>Anticancer research</jtitle><addtitle>Anticancer Res</addtitle><date>2009-12-01</date><risdate>2009</risdate><volume>29</volume><issue>12</issue><spage>5229</spage><epage>5234</epage><pages>5229-5234</pages><issn>0250-7005</issn><eissn>1791-7530</eissn><abstract>The identification of risk factors for ovarian cancer is crucial in prevention of the disease. This pathology is the leading
cause of death from gynecological malignancies. The aim of this study was to evaluate the role of factors influencing hormonal
levels such as body mass index (BMI), BMI at age 20, waist-to-hip ratio (WHR), oral contraceptive (OC) use, and risk of ovarian
cancer. A case-control study was conducted in women who developed ovarian cancer. Logistic regression was used to calculate
the odds ratio (OR) and 95% confidence interval (95% CI). While no association was found between BMI, BMI at age 20 and risk
of ovarian cancer, high WHR increased the risk with ORs of 2.93 and 8.58 (p<10 â6 ) for the highest categories (WHR=0.801-0.85 and WHR>0.85) versus the lowest (WHR<0.8). Central adiposity is a key factor
in ovarian cancer and suggests the involvement of androgen conversion in adipose tissue.</abstract><cop>Greece</cop><pub>International Institute of Anticancer Research</pub><pmid>20044641</pmid><tpages>6</tpages></addata></record> |
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| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Adipose Tissue - physiopathology Adiposity - physiology Adult Aged Aged, 80 and over Case-Control Studies Female Follow-Up Studies Humans Middle Aged Obesity - complications Ovarian Neoplasms - complications Ovarian Neoplasms - physiopathology Risk Factors Waist-Hip Ratio |
| title | Central Adiposity as a Major Risk Factor of Ovarian Cancer |
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