1 beta, 25 (OH)2-vitamin D3 is an antagonist of 1 alpha,25 (OH)2-vitamin D3 stimulated transcaltachia (the rapid hormonal stimulation of intestinal calcium transport)

The steroid hormone 1 alpha,25-dihydroxyvitamin-D3 [1 alpha,25(OH)2D3] stimulates biological responses via both genomic mechanisms and nongenomic mechanisms (opening of voltage-gated Ca2+ channels). We report here that 1 beta, 25(OH)2-vitamin-D3 (a) is devoid of activity as an agonist for transcalta...

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Veröffentlicht in:	Biochemical and biophysical research communications 1992-12, Vol.189 (3), p.1450-1456
Hauptverfasser:	Norman, A W, Nemere, I, Muralidharan, K R, Okamura, W H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding, Competitive Calcitriol - antagonists & inhibitors Calcitriol - metabolism Calcitriol - pharmacology Calcium - metabolism Chickens Duodenum - metabolism Intestinal Absorption - drug effects Male Receptors, Calcitriol Receptors, Steroid - drug effects Receptors, Steroid - metabolism Stereoisomerism Structure-Activity Relationship Vitamin D - pharmacology Vitamin D Deficiency - metabolism
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