1 beta, 25 (OH)2-vitamin D3 is an antagonist of 1 alpha,25 (OH)2-vitamin D3 stimulated transcaltachia (the rapid hormonal stimulation of intestinal calcium transport)
The steroid hormone 1 alpha,25-dihydroxyvitamin-D3 [1 alpha,25(OH)2D3] stimulates biological responses via both genomic mechanisms and nongenomic mechanisms (opening of voltage-gated Ca2+ channels). We report here that 1 beta, 25(OH)2-vitamin-D3 (a) is devoid of activity as an agonist for transcalta...
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| Veröffentlicht in: | Biochemical and biophysical research communications 1992-12, Vol.189 (3), p.1450-1456 |
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| container_issue | 3 |
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| container_title | Biochemical and biophysical research communications |
| container_volume | 189 |
| creator | Norman, A W Nemere, I Muralidharan, K R Okamura, W H |
| description | The steroid hormone 1 alpha,25-dihydroxyvitamin-D3 [1 alpha,25(OH)2D3] stimulates biological responses via both genomic mechanisms and nongenomic mechanisms (opening of voltage-gated Ca2+ channels). We report here that 1 beta, 25(OH)2-vitamin-D3 (a) is devoid of activity as an agonist for transcaltachia, (b) is a potent stereospecific antagonist of 1 alpha,25 (OH)2D3 stimulation of the nongenomic transcaltachia response and also (c) has less than 1% the ability of 1 alpha,25(OH)2D3 to bind to the chick intestinal nuclear 1 beta,25(OH)2D3 receptor. We conclude that the membrane response element(s) which generates the nongenomic response of transcaltachia has a different ligand specificity than the classic nuclear 1 alpha, 25(OH)2D3 receptor. |
| doi_str_mv | 10.1016/0006-291X(92)90237-F |
| format | Article |
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We report here that 1 beta, 25(OH)2-vitamin-D3 (a) is devoid of activity as an agonist for transcaltachia, (b) is a potent stereospecific antagonist of 1 alpha,25 (OH)2D3 stimulation of the nongenomic transcaltachia response and also (c) has less than 1% the ability of 1 alpha,25(OH)2D3 to bind to the chick intestinal nuclear 1 beta,25(OH)2D3 receptor. 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We report here that 1 beta, 25(OH)2-vitamin-D3 (a) is devoid of activity as an agonist for transcaltachia, (b) is a potent stereospecific antagonist of 1 alpha,25 (OH)2D3 stimulation of the nongenomic transcaltachia response and also (c) has less than 1% the ability of 1 alpha,25(OH)2D3 to bind to the chick intestinal nuclear 1 beta,25(OH)2D3 receptor. We conclude that the membrane response element(s) which generates the nongenomic response of transcaltachia has a different ligand specificity than the classic nuclear 1 alpha, 25(OH)2D3 receptor.</description><subject>Animals</subject><subject>Binding, Competitive</subject><subject>Calcitriol - antagonists & inhibitors</subject><subject>Calcitriol - metabolism</subject><subject>Calcitriol - pharmacology</subject><subject>Calcium - metabolism</subject><subject>Chickens</subject><subject>Duodenum - metabolism</subject><subject>Intestinal Absorption - drug effects</subject><subject>Male</subject><subject>Receptors, Calcitriol</subject><subject>Receptors, Steroid - drug effects</subject><subject>Receptors, Steroid - metabolism</subject><subject>Stereoisomerism</subject><subject>Structure-Activity Relationship</subject><subject>Vitamin D - pharmacology</subject><subject>Vitamin D Deficiency - metabolism</subject><issn>0006-291X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1992</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkM9Kw0AQh_eg1Fp9A4U9SQuN7p8mmxylWisUelHwFiabXbOS7MbspuAL-ZymtPQkDAz85puPYRC6oeSeEpo8EEKSiGX0Y5qxWUYYF9HqDI1P8QW69P6LEEoXSTZCI8p5wpN0jH4pLlSAOWYxnm7XMxbtTIDGWPzEsfEY7FABPp01PmCnMcVQtxXM_-N9ME1fQ1AlDh1YL6EOICsDeBoqhTtoTYkr1zXOQn2ijbN7sbFBDdF-MuxJ0zcHSeu6MLtC5xpqr66PfYLeV89vy3W02b68Lh83UUt5GqJUxkrLgqlUMCYI10wCl4IwxlVMSx1LnWpdZmmmy1hLyoUSEooB1URwlfIJujt4285998M9eWO8VHUNVrne54IvGOWLZABvj2BfNKrM28400P3kx8fyP1M6eb8</recordid><startdate>19921230</startdate><enddate>19921230</enddate><creator>Norman, A W</creator><creator>Nemere, I</creator><creator>Muralidharan, K R</creator><creator>Okamura, W H</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19921230</creationdate><title>1 beta, 25 (OH)2-vitamin D3 is an antagonist of 1 alpha,25 (OH)2-vitamin D3 stimulated transcaltachia (the rapid hormonal stimulation of intestinal calcium transport)</title><author>Norman, A W ; Nemere, I ; Muralidharan, K R ; Okamura, W H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p138t-8c5efcb2e8722703f2ca3c70223e51df5cf8ffd989fd5fc137e7cab270f073e83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1992</creationdate><topic>Animals</topic><topic>Binding, Competitive</topic><topic>Calcitriol - antagonists & inhibitors</topic><topic>Calcitriol - metabolism</topic><topic>Calcitriol - pharmacology</topic><topic>Calcium - metabolism</topic><topic>Chickens</topic><topic>Duodenum - metabolism</topic><topic>Intestinal Absorption - drug effects</topic><topic>Male</topic><topic>Receptors, Calcitriol</topic><topic>Receptors, Steroid - drug effects</topic><topic>Receptors, Steroid - metabolism</topic><topic>Stereoisomerism</topic><topic>Structure-Activity Relationship</topic><topic>Vitamin D - pharmacology</topic><topic>Vitamin D Deficiency - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Norman, A W</creatorcontrib><creatorcontrib>Nemere, I</creatorcontrib><creatorcontrib>Muralidharan, K R</creatorcontrib><creatorcontrib>Okamura, W H</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Norman, A W</au><au>Nemere, I</au><au>Muralidharan, K R</au><au>Okamura, W H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>1 beta, 25 (OH)2-vitamin D3 is an antagonist of 1 alpha,25 (OH)2-vitamin D3 stimulated transcaltachia (the rapid hormonal stimulation of intestinal calcium transport)</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>1992-12-30</date><risdate>1992</risdate><volume>189</volume><issue>3</issue><spage>1450</spage><epage>1456</epage><pages>1450-1456</pages><issn>0006-291X</issn><abstract>The steroid hormone 1 alpha,25-dihydroxyvitamin-D3 [1 alpha,25(OH)2D3] stimulates biological responses via both genomic mechanisms and nongenomic mechanisms (opening of voltage-gated Ca2+ channels). We report here that 1 beta, 25(OH)2-vitamin-D3 (a) is devoid of activity as an agonist for transcaltachia, (b) is a potent stereospecific antagonist of 1 alpha,25 (OH)2D3 stimulation of the nongenomic transcaltachia response and also (c) has less than 1% the ability of 1 alpha,25(OH)2D3 to bind to the chick intestinal nuclear 1 beta,25(OH)2D3 receptor. We conclude that the membrane response element(s) which generates the nongenomic response of transcaltachia has a different ligand specificity than the classic nuclear 1 alpha, 25(OH)2D3 receptor.</abstract><cop>United States</cop><pmid>1336368</pmid><doi>10.1016/0006-291X(92)90237-F</doi><tpages>7</tpages></addata></record> |
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| identifier | ISSN: 0006-291X |
| ispartof | Biochemical and biophysical research communications, 1992-12, Vol.189 (3), p.1450-1456 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Binding, Competitive Calcitriol - antagonists & inhibitors Calcitriol - metabolism Calcitriol - pharmacology Calcium - metabolism Chickens Duodenum - metabolism Intestinal Absorption - drug effects Male Receptors, Calcitriol Receptors, Steroid - drug effects Receptors, Steroid - metabolism Stereoisomerism Structure-Activity Relationship Vitamin D - pharmacology Vitamin D Deficiency - metabolism |
| title | 1 beta, 25 (OH)2-vitamin D3 is an antagonist of 1 alpha,25 (OH)2-vitamin D3 stimulated transcaltachia (the rapid hormonal stimulation of intestinal calcium transport) |
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